The impact of immunohistochemical staining with ezrin-carbonic anhydrase IX and neuropilin-2 on prognosis in patients with metastatic renal cell cancer receiving tyrosine kinase inhibitors

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dc.authoridbenekli, mustafa -- 0000-0003-3184-4946en_US
dc.contributor.authorCetin, Bulent
dc.contributor.authorGonu, Ipek Isik
dc.contributor.authorBuyukberber, Suleyman
dc.contributor.authorAfsar, Bans
dc.contributor.authorGumusay, Ozge
dc.contributor.authorAlgm, Efnan
dc.contributor.authorTuran, Nedim
dc.contributor.authorOzet, Ahmet
dc.contributor.authorBenekli, Mustafa
dc.contributor.authorCoskun, Ugur
dc.date.accessioned2019-07-27T12:10:23Z
dc.date.accessioned2019-07-28T09:47:30Z
dc.date.available2019-07-27T12:10:23Z
dc.date.available2019-07-28T09:47:30Z
dc.date.issued2015
dc.department[Cetin, Bulent] Van Educ & Res Hosp, Dept Internal Med, Div Med Oncol, TR-65100 Van, Turkey -- [Gonu, Ipek Isik] Gazi Univ, Fac Med, Dept Pathol, Ankara, Turkey -- [Buyukberber, Suleyman -- Gumusay, Ozge -- Ozet, Ahmet -- Benekli, Mustafa -- Coskun, Ugur] Gazi Univ, Fac Med, Dept Internal Med, Div Med Oncol, Ankara, Turkey -- [Afsar, Bans] Konya Numune State Hosp, Dept Internal Med, Div Nephrol, Konya, Turkey -- [Algm, Efnan] Ankara Numune Training & Res Hosp, Dept Internal Med, Div Med Oncol, Ankara, Turkey -- [Turan, Nedim] Cumhuriyet Univ, Fac Med, Dept Internal Med, Div Med Oncol, Sivas, Turkeyen_US
dc.description.abstractThe identification of prognostic factors in patients with renal cell carcinoma (RCC) represents an area of increasing interest. In this retrospective study, we evaluated the prognostic role of carbonic anhydrase-IX, ezrin, and neuropilin in metastatic RCC patients. The expression of several biomarkers were measured by immunohistochemistry (IHC) in 45 patients with advanced stage RCC treated with second-line tyrosine kinase inhibitors (TKIs) targeting vascular endothelial growth factor (VEGF) after failure of interferon-alpha between January 2007 and June 2012. Kaplan-Meier curves and log-rank tests were used for analysis of progression-free survival (PFS) and overall survival (OS), and a multivariate Cox proportional hazard model was employed to identify factors with an independent effect on the survival. Age, ezrin and neuropilin-2 overexpression were found to be statistically significant factors (P < 0.05) for PFS in the univariate analysis. Ezrin and neuropilin-2 overexpression, hemoglobin and albumin level were statistically significant factors (P < 0.05) for OS in the univariate analysis. Multivariate analysis revealed that low expression of ezrin and neuropilin-2 was an independent prognostic factor for PFS and OS. The median PFS was 4 months for patients overexpressing neuropilin-2 versus 11 months for those with lower expression of neuropilin-2 (p = 0.033). The median OS was longer in patients with low levels of neuropilin-2 expression (26 months) compared to patients overexpressing neuropilin-2 (13 months) (p = 0.023). Increased expression of ezrin was associated with poor prognosis in patients treated with TKIs targeting VEGF (PFS, 3 vs 7 months; p = 0.012). High ezrin expression was associated with shorter OS (p = 0.009). This is the first study in the literature showing that neuropilin-2 and ezrin are related with prognosis in patients with advanced RCC.en_US
dc.identifier.doi10.1007/s13277-015-3589-6en_US
dc.identifier.endpage8478en_US
dc.identifier.issn1010-4283
dc.identifier.issn1423-0380
dc.identifier.issue11en_US
dc.identifier.pmid26026587en_US
dc.identifier.scopus2-s2.0-84949089279en_US
dc.identifier.scopusqualityQ2
dc.identifier.startpage8471en_US
dc.identifier.urihttps://dx.doi.org/10.1007/s13277-015-3589-6
dc.identifier.urihttps://hdl.handle.net/20.500.12418/7685
dc.identifier.volume36en_US
dc.identifier.wosWOS:000366143100031en_US
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSAGE PUBLICATIONS LTDen_US
dc.relation.ispartofTUMOR BIOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAdvanced renal cell carcinomaen_US
dc.subjectMolecular markersen_US
dc.subjectTargeted drugsen_US
dc.subjectPrognostic factorsen_US
dc.titleThe impact of immunohistochemical staining with ezrin-carbonic anhydrase IX and neuropilin-2 on prognosis in patients with metastatic renal cell cancer receiving tyrosine kinase inhibitorsen_US
dc.typeArticleen_US

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