Association of deep venous thrombosis with prothrombotic gene polymorphism identified in lung cancer cases

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dc.authoridKarahan, Oguz -- 0000-0003-0044-9476en_US
dc.contributor.authorArslan, Sulhattin
dc.contributor.authorManduz, Sinasi
dc.contributor.authorEpozturk, Kursat
dc.contributor.authorKarahan, Oguz
dc.contributor.authorAkkurt, Ibrahim
dc.date.accessioned2019-07-27T12:10:23Z
dc.date.accessioned2019-07-28T10:05:44Z
dc.date.available2019-07-27T12:10:23Z
dc.date.available2019-07-28T10:05:44Z
dc.date.issued2011
dc.department[Arslan, Sulhattin -- Epozturk, Kursat -- Akkurt, Ibrahim] Cumhuriyet Univ, Fac Med, Dept Chest Dis, TR-58140 Sivas, Turkey -- [Manduz, Sinasi -- Karahan, Oguz] Cumhuriyet Univ, Fac Med, Dept Cardiovasc Surg, TR-58140 Sivas, Turkeyen_US
dc.description.abstractVenous thrombosis is a significant cause of morbidity and mortality in patients with malignancies. We aimed to investigate the association between prothrombotic gene polymorphisms detected in lung cancer cases and deep venous thrombosis (DVT). Totally 66 patients with an established diagnosis of lung cancer, of which 33 developed DVT, were enrolled. Multiplex PCR technique and reverse hybridization strip assay were performed on DNA extracted from peripheral blood, in order to analyze prothrombin G20210A, factor V G1691A, methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C, angiotensin converting enzyme (ACE), plasminogen activator inhibitor-1 (PAI-1), and glycoprotein IIIa (Gp IIIa) gene mutations. Among prothrombotic gene polymorphisms investigated in this study, the commonest ones were PAI-1 4G/5G (56% heterozygous, 39% homozygous) and ACE gene mutations (58% heterozygous, 17% homozygous). The presence of homozygous MTHFR A1298C mutation was significantly associated with DVT (P = 0.020). Comparing the lung cancer patients with and without DVT, only MTHFR A1298C gene polymorphism differed significantly (P = 0.040). We determined a higher rate of prothrombotic gene mutations in lung cancer patients who developed DVT. However, statistical significance was achieved only for MTHFR A1298C gene mutation. Therefore, nongenetic factors for disturbance of hemostatic metabolism should also be considered in lung cancer patients.en_US
dc.identifier.doi10.1007/s11033-010-0373-yen_US
dc.identifier.endpage2400en_US
dc.identifier.issn0301-4851
dc.identifier.issn1573-4978
dc.identifier.issue4en_US
dc.identifier.pmid21080081en_US
dc.identifier.scopus2-s2.0-79960944871en_US
dc.identifier.scopusqualityQ2
dc.identifier.startpage2395en_US
dc.identifier.urihttps://dx.doi.org/10.1007/s11033-010-0373-y
dc.identifier.urihttps://hdl.handle.net/20.500.12418/9566
dc.identifier.volume38en_US
dc.identifier.wosWOS:000289257100023en_US
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSPRINGERen_US
dc.relation.ispartofMOLECULAR BIOLOGY REPORTSen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectThrombosisen_US
dc.subjectGeneen_US
dc.subjectMutationen_US
dc.subjectLung canceren_US
dc.titleAssociation of deep venous thrombosis with prothrombotic gene polymorphism identified in lung cancer casesen_US
dc.typeArticleen_US

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