Involvement of nitric oxide pathway in the acute anticonvulsant effect of salmon calcitonin in rats

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dc.contributor.authorFiliz, Ahmet Kemal
dc.contributor.authorKarabulut, Sebahattin
dc.date.accessioned2024-10-26T18:04:16Z
dc.date.available2024-10-26T18:04:16Z
dc.date.issued2022
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractEpilepsy is a chronic neurological disease that is thought to affect up to 1% of the world's population. Evidence suggests that salmon calcitonin (sCT) has positive effects on epileptic seizures and epileptogenesis. However, it remains unknown that whether nitric oxide (NO) pathway contributed to this antiepileptic effect of sCT. We have used the pentylenetetrazole (PTZ)-induced seizure rat model to identify the effect of sCT on seizure score, seizure-induced cognitive deficit, and the NO pathway in the brain. We found that sCT increases the first myoclonic jerk (FMJ), decreased Racine's convulsion scale (RCS), and abates seizure-induced cognitive impairment. We further demonstrated that sCT attenuated the abnormal increase of NO in the brain. These results revealed that sCT exerts an antiepileptic effect by modulating the NO pathway in the brain.
dc.identifier.doi10.1016/j.eplepsyres.2022.106864
dc.identifier.issn0920-1211
dc.identifier.issn1872-6844
dc.identifier.pmid35066437
dc.identifier.scopus2-s2.0-85122956134
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1016/j.eplepsyres.2022.106864
dc.identifier.urihttps://hdl.handle.net/20.500.12418/28847
dc.identifier.volume180
dc.identifier.wosWOS:000820113600012
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofEpilepsy Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectSalmon calcitonin
dc.subjectPentylenetetrazole
dc.subjectNeuroinflammation
dc.subjectNitric oxide
dc.subjectRat
dc.titleInvolvement of nitric oxide pathway in the acute anticonvulsant effect of salmon calcitonin in rats
dc.typeArticle

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