A Negative Correlation Between MEFV Mutations and Allergic Diseases

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dc.contributor.authorYildirim, Malik Ejder
dc.contributor.authorKurtulgan, Hande Kucuk
dc.contributor.authorKilicgun, Hasan
dc.contributor.authorDuksal, Fatma
dc.date.accessioned2024-10-26T18:00:29Z
dc.date.available2024-10-26T18:00:29Z
dc.date.issued2022
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractAim: Atopy is associated with a genetic predisposition to develop allergic diseases such as allergic rhinitis, asthma, and atopic dermatitis. In this study, we aimed to compare the prevalence of Familial Mediterranean Fever (FMF) mutations in asthma and allergic rhinitis patients with controls in the pediatric population and to analyse the positive or negative effect of MEFV mutations in the development of atopy. Materials and Methods: For the detection of FMF mutations, 88 pediatric patients (51 allergic asthma, 17 allergic rhinitis and 20 both asthma and allergic rhinitis cases) and 92 controls were included in our study. Total genomic DNA was extracted from peripheral blood samples using DNA isolation kit. Then, the patient and control groups were screened for MEFV gene mutations by Reverse Hybridization procedure (Strip Assay). Results: There were 9 carriers (heterozygous mutation) in the patient group. The control group had 21 carriers and 1 individual with a compound heterozygous mutation. It was not detected any homozygous mutation in both two groups. The number of individuals with mutation was statistically higher in the control group than in the patients of asthma and allergic rhinitis (p=0.015) and the mutation number (allelic frequency) in the control group was also higher than in the patients (p=0.014). Conclusion: We suggest that FMF mutations are less frequent in allergic rhinitis and asthma cases than in the normal population. Asthma and allergic rhinitis may be more common in individuals without FMF mutation. It can be thought that MEFV gene mutations are effective to prevent allergic reactions on the basis of T helper 2 (Th2) suppression.
dc.identifier.doi10.4274/jpr.galenos.2021.33407
dc.identifier.endpage137
dc.identifier.issn2147-9445
dc.identifier.issue2
dc.identifier.startpage132
dc.identifier.trdizinid519150
dc.identifier.urihttps://doi.org/10.4274/jpr.galenos.2021.33407
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/519150
dc.identifier.urihttps://hdl.handle.net/20.500.12418/27710
dc.identifier.volume9
dc.identifier.wosWOS:000805325700006
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherGalenos Yayincilik
dc.relation.ispartofJournal of Pediatric Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAllergic rhinitis
dc.subjectasthma
dc.subjectFMF
dc.subjectMEFV gene
dc.subjectmutation
dc.titleA Negative Correlation Between MEFV Mutations and Allergic Diseases
dc.typeArticle

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