Labetalol, nebivolol, and propranolol relax human radial artery used as coronary bypass graft

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dc.contributor.authorKorkmaz, Ozge
dc.contributor.authorSarac, Bulent
dc.contributor.authorGoksel, Sabahattin
dc.contributor.authorYildirim, Sahin
dc.contributor.authorBerkan, Ocal
dc.contributor.authorBagcivan, Ihsan
dc.date.accessioned2019-07-27T12:10:23Z
dc.date.accessioned2019-07-28T09:56:13Z
dc.date.available2019-07-27T12:10:23Z
dc.date.available2019-07-28T09:56:13Z
dc.date.issued2015
dc.department[Korkmaz, Ozge -- Goksel, Sabahattin -- Berkan, Ocal] Cumhuriyet Univ, Sch Med, Dept Cardiovasc Surg, TR-58140 Sivas, Turkey -- [Sarac, Bulent -- Yildirim, Sahin -- Bagcivan, Ihsan] Cumhuriyet Univ, Sch Med, Dept Pharmacol, TR-58140 Sivas, Turkeyen_US
dc.description.abstractObjective: Beta-blockers are a heterogeneous class of agents that are used in the treatment of many cardiovascular diseases, especially hypertension and atherosclerosis, and that are commonly prescribed after cardiac surgery. In the present study, the aim is to investigate the vasorelaxant effects of some common beta-adrenoceptor blockers on the human radial artery in vitro, as well as their relaxation mechanisms. Methods: Radial artery rings sourced from human patients were mounted in an organ bath and tested for changes in isometric tension in relaxation response to labetalol, nebivolol, and propranolol in the presence and absence of NG-nitro-L-arginine methyl ester (3 x 10(-5) mol/L) and tetraethyl ammonium (3 x 10(-4) mol/L). Results: The labetalol (10(-8) to 10(-4) mol/L), nebivolol (10(-8) to 10(-4) mol/L), and propranolol (10(-8) to 10(-4) mol/L) induced concentration-dependent relaxations on the radial artery rings, which had been precontracted with phenylephrine (10(-6) mol/L). The relaxation response induced by labetalol in the isolated radial artery rings was significantly higher when compared with the nebivolol and propranolol samples (P < .05). NG-nitro-L-arginine methyl ester significantly reduced the relaxation of nebivolol (P <. 05), and tetraethyl ammonium significantly reduced the relaxation of labetalol, nebivolol, and propranolol (P < .05). Conclusions: We speculated that the relaxant effect of labetalol, nebivolol, and propranolol was due partly to the Ca2+-activated K+ channels. In addition, the relaxation induced by nebivolol was largely related with nitric oxide release. Nebivolol, and partly propranolol, may provide significant therapeutic benefit, but labetalol can be a good alternative for coronary artery bypass grafting with radial artery use.en_US
dc.identifier.doi10.1016/j.jtcvs.2015.01.006en_US
dc.identifier.endpage1040en_US
dc.identifier.issn0022-5223
dc.identifier.issn1097-685X
dc.identifier.issue4en_US
dc.identifier.pmid25749140en_US
dc.identifier.scopus2-s2.0-84928207483en_US
dc.identifier.scopusqualityQ1
dc.identifier.startpage1036en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.jtcvs.2015.01.006
dc.identifier.urihttps://hdl.handle.net/20.500.12418/7895
dc.identifier.volume149en_US
dc.identifier.wosWOS:000353347600031en_US
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMOSBY-ELSEVIERen_US
dc.relation.ispartofJOURNAL OF THORACIC AND CARDIOVASCULAR SURGERYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleLabetalol, nebivolol, and propranolol relax human radial artery used as coronary bypass graften_US
dc.typeArticleen_US

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