Synthesis and Biological Evaluation of Novel 1-(4-(Hydroxy(1-oxo-1,3-dihydro-2H-inden-2-ylidene)methyl)phenyl)-3-phenylurea Derivatives

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dc.authoridGezegen, Hayreddin -- 0000-0003-3602-7400en_US
dc.contributor.authorGezegen, Hayreddin
dc.contributor.authorHepokur, Ceylan
dc.contributor.authorTutar, Ugur
dc.contributor.authorCeylan, Mustafa
dc.date.accessioned2019-07-27T12:10:23Z
dc.date.accessioned2019-07-28T09:40:09Z
dc.date.available2019-07-27T12:10:23Z
dc.date.available2019-07-28T09:40:09Z
dc.date.issued2017
dc.department[Gezegen, Hayreddin -- Tutar, Ugur] Cumhuriyet Univ, Dept Nutr & Dietet, Fac Hlth Sci, TR-58140 Sivas, Turkey -- [Hepokur, Ceylan] Cumhuriyet Univ, Dept Biochem, Fac Pharm, TR-58140 Sivas, Turkey -- [Ceylan, Mustafa] Gaziosmanpasa Univ, Dept Chem, Fac Arts & Sci, TR-60250 Tokat, Turkeyen_US
dc.description.abstractA series of novel phenylurea containing 2-benzoylindan-1-one derivatives 3a - 3j were synthesized from the reaction of phenylurea-substituted acetophenones 1a - 1j with phthalaldehyde 2 under mild reaction conditions in good yields. All synthesized compounds were characterized by spectroscopic methods. The obtained compounds (3a - 3j) were evaluated for anticancer activity against HeLa and C6 cell lines. Antiproliferative activity was determined by the BrdU proliferation ELISA assay, 3f and 3g were found to be most active compounds. The compounds were also screened for antimicrobial activity and all compounds showed remarkable activity against used microorganisms.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey [TUBITAK-114Z634]en_US
dc.description.sponsorshipThe authors are indebted to the The Scientific and Technological Research Council of Turkey (Grant TUBITAK-114Z634) for financial support of this work.en_US
dc.identifier.doi10.1002/cbdv.201700223en_US
dc.identifier.issn1612-1872
dc.identifier.issn1612-1880
dc.identifier.issue10en_US
dc.identifier.pmid28865181en_US
dc.identifier.scopus2-s2.0-85031712329en_US
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://dx.doi.org/10.1002/cbdv.201700223
dc.identifier.urihttps://hdl.handle.net/20.500.12418/6637
dc.identifier.volume14en_US
dc.identifier.wosWOS:000417435200011en_US
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWILEY-V C H VERLAG GMBHen_US
dc.relation.ispartofCHEMISTRY & BIODIVERSITYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject2-Benzoylindan-1-oneen_US
dc.subjectPhenylureaen_US
dc.subjectAnticancer activityen_US
dc.subjectApoptosisen_US
dc.subjectAntimicrobial activityen_US
dc.titleSynthesis and Biological Evaluation of Novel 1-(4-(Hydroxy(1-oxo-1,3-dihydro-2H-inden-2-ylidene)methyl)phenyl)-3-phenylurea Derivativesen_US
dc.typeArticleen_US

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