Browsing by Author "Ozdemir, Ozturk"
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Aldosterone Synthase CYP11B2 Gene Promoter Polymorphism in a Turkish Population With Chronic Kidney Disease
Yilmaz, Meral; Sari, Ismail; Bagci, Binnur; Gumus, Erkan; Ozdemir, Ozturk (IRANIAN SOC NEPHROLGY, 2015)Introduction. It has been shown that gene polymorphisms influence the development and progression of chronic kidney disease (CKD). Many studies have indicated that aldosterone synthase CYP11B2 gene polymorphism (-344C>T) ... -
ANGIOTENSIN CONVERTING ENZYME (ACE) GENE POLYMORPHISM AND BUERGER'S DISEASE
Ozen, Filiz; Kocak, Nadir; Ozdemir, Ozturk; Sezgin, Ilhan (JOHN WILEY & SONS INC, 2009)… -
Association between ABCB1 (MDR1) Gene 3435 C > T Polymorphism and Colchicine Unresponsiveness of FMF Patients
Ozen, Filiz; Silan, Coskun; Uludag, Ahmet; Candan, Ferhan; Silan, Fatma; Ozdemir, Semra; Atik, Sinem; Ozdemir, Ozturk (TAYLOR & FRANCIS LTD, 2011)The multidrug resistance gene-1 (MDR1, adenosine triphosphate-binding cassette transporter: ABCB1, P-glycoprotein) encodes membrane proteins that play a crucial role in protecting cells from xenobiotics, chemicals, and ... -
Association Between ABCB1 (MDR1) Gene Polymorphism and Unresponsiveness Combined Therapy in Chronic Hepatitis C virus
Timucin, Meryem; Alagozlu, Hakan; Ozdemir, Semra; Ozdemir, Ozturk (KOWSAR PUBL, 2013)Background: To treat viral infection of chronic hepatitis C (CHC) is a main strategy to prevent progression of liver disease, and cancer. Some patients with CHC have failed to respond to the common antiviral therapy in ... -
Association Between ApoE4 Allele and Deep Venous Thrombosis: A Pilot Study
Katrancioglu, Nurkay; Manduz, Sinasi; Ozen, Filiz; Yilmaz, Mehmet Birhan; Atahan, Erhan; Ozdemir, Ozturk; Berkan, Ocal (SAGE PUBLICATIONS INC, 2011)Materials and Methods: We aimed to search the relative frequencies ApoE alleles among patients with DVT and healthy participants. We enrolled 59 consecutive patients with DVT and 59 age- and sex-matched healthy controls. ... -
The association between methylene-tetrahydrofolate reductase gene polymorphism and lung cancer risk
Arslan, Sulhattin; Karadayi, Sule; Yildirim, Malik Ejder; Ozdemir, Ozturk; Akkurt, Ibrahim (SPRINGER, 2011)This study aimed to determine the relation between methylene-tetrahydrofolate reductase (MTHFR) gene polymorphism and lung cancer risk and the frequency of this polymorphism. The study involved 64 lung cancer patients (the ... -
Association of endothelial nitric oxide synthase Glu298Asp gene polymorphism in psoriasis cases with hypertension
Ogretmen, Zerrin; Hiz, Meliha Merve; Silan, Fatma; Uludag, Ahmet; Ozdemir, Ozturk (K FAISAL SPEC HOSP RES CENTRE, 2014)BACKGROUND AND OBJECTIVES: Psoriasis is a common autoimmune-mediated chronic, inflammatory skin disease. Although, the molecular mechanism is not completely understood, psoriasis is caused by genetic and non-genetic ... -
Associations between common 3435 C > T variants of the multi-drug resistance [MDR-1 (ABCB1)] gene and abdominal aortic aneurysm: a pilot study
Manduz, Sinasi; Katrancioglu, Nurkay; Karahan, Oguz; Yilmaz, Mehmet Birhan; Ozdemir, Ozturk; Berkan, Ocal (EKIN TIBBI YAYINCILIK LTD STI-EKIN MEDICAL PUBL, 2011)Background: The aim of the study was to reveal the effect of the C3435T MDR-1 gene polymorphism in AAA, which has been postulated to play a role in the inflammatory process and protection against oxidative stress. Methods: ... -
Associations of fractalkine receptor (CX3CR1) and CCR5 gene variants with hypertension, diabetes and atherosclerosis in chronic renal failure patients undergoing hemodialysis
Bagci, Binnur; Bagci, Gokhan; Huzmeli, Can; Sezgin, Ilhan; Ozdemir, Ozturk (SPRINGER, 2016)We aimed to investigate the associations of fractalkine receptor (CX3CR1) V249I, T280M and CCR5-59029 A/G gene polymorphisms in chronic renal failure (CRF) subjects undergoing hemodialysis and to evaluate possible associations ... -
Bcii-RFLP profiles for serum amiloid A1 and mutated MEFV gene prevalence in chronic renal failure patients requiring long-term hemodialysis
Ozdemir, Ozturk; Kayatas, Mansur; Cetinkaya, Selma; Yildirim, Malik Ejder; Silan, Fatma; Kurtulgan, Hande Kucuk; Koksal, Binnur; Urfali, Mine; Candan, Ferhan (TAYLOR & FRANCIS LTD, 2015)Background and aim: There is an increased mortality risk in long-term hemodialysis patients of renal failure due to the chronic inflammation. The relationship between the chronic renal failure (CRF) and the role of familial ... -
CCR2 Polymorphism in Chronic Renal Failure Patients Requiring Long-Term Hemodialysis
Sezgin, Ilhan; Koksal, Binnur; Bagci, Gokhan; Kurtulgan, Hande Kucuk; Ozdemir, Ozturk (JAPAN SOC INTERNAL MEDICINE, 2011)Objective A number of chemokines and chemokine receptors are produced by intrinsic renal cells as well as by infiltrating cells during renal inflammation. The CCR2 chemokine receptor mediates leukocyte chemoattraction in ... -
Chemokine receptor 5 Delta 32 gene polymorphism and abdominal aortic aneurysms
Aydin, Murat; Katrancioglu, Nurkay; Manduz, Sinasi; Atahan, Erhan; Karahan, Oguz; Ozdemir, Ozturk; Berkan, Ocai (BAYCINAR MEDICAL PUBL-BAYCINAR TIBBI YAYINCILIK, 2010)Background: In this study, we aimed to investigate the relationship between abdominal aortic aneurysm (AAA) and chemokine receptor 5 Delta 32 (CCR5) gene polymorphism as a risk factor. Methods: Fifty-eight patients (41 ... -
Clinical and molecular analysis of common MEFV gene mutations in familial Mediterranean fever in Sivas population
Koksal, Binnur; Nur, Naim; Sari, Musa; Candan, Ferhan; Acemoglu, Mursit; Kocak, Nadir; Ozen, Filiz; Ozdemir, Ozturk (SPRINGER, 2009)Familial Mediterranean fever (FMF) is the most frequent hereditary inflammatory disease characterized by self-limited recurrent attacks of fever and serositis. The aim of the current study is to determine the frequency of ... -
Combined Effect of Factor V Leiden, MTHFR, and Angiotensin-Converting Enzyme (Insertion/Deletion) Gene Mutations in Hypertensive Adult Individuals: A Population-Based Study from Sivas and Canakkale, Turkey
Demirel, Yeltekin; Dogan, Sezai; Uludag, Ahmet; Silan, Coskun; Atik, Sinem; Silan, Fatma; Ozdemir, Ozturk (MARY ANN LIEBERT INC, 2011)Background: Hypertension is one of the leading causes of mortality and morbidity in the world, which is influenced by environmental and genetic factors. The methylenetetrahydrofolate reductase (MTHFR) and angiotensin-converting ... -
Combined Germline Variations of Thrombophilic Genes Promote Genesis of Lung Cancer
Ozen, Filiz; Polat, Fikriye; Arslan, Sulhattin; Ozdemir, Ozturk (ASIAN PACIFIC ORGANIZATION CANCER PREVENTION, 2013)Background: A large variety of familiar and non-familiar lung carcinomas (LC) are caused by long term exposure to chemical carcinogens that are present in tobacco smoke. We aimed to investigate the prevalence of 5 thrombophilic ... -
Combined point mutations in codon 12 and 13 of KRAS oncogene in prostate carcinomas
Silan, Fatma; Gultekin, Yener; Atik, Sinem; Kilinc, Davran; Alan, Cabir; Yildiz, Fazilet; Uludag, Ahmet; Ozdemir, Ozturk (SPRINGER, 2012)Prostate cancer is a common malignancy that develops by structural mutation(s) and/or other genetic alterations in specific genes.The G to T transversions in codon 12 and C to T transitions in codon 13 of KRAS proto-oncogene ... -
The CYP4502D6*4 and*6 alleles are the molecular genetic markers for drug response: implications in colchicine non-responder FMF patients
Yalcintepe, Sinem; Ozdemir, Ozturk; Silan, Coskun; Ozen, Filiz; Uludag, Ahmet; Candan, Ferhan; Silan, Fatma (SPRINGER FRANCE, 2016)The cytochrome P450 2D6 (CYP2D6) is a cytochrome P450 enzyme involved in the oxidative biotransformation of the xenobiotics, carcinogens and various clinically important drugs. Patients are evaluated in three sub-groups ... -
Cytochrome P450 2D6 and MDR1 Gene Mutation in Relation to Mortality in Patients with Crimean-Congo Hemorrhagic Fever: A Preliminary Study
Engin, Aynur; Koksal, Binnur; Dogan, Omer Tamer; Elaldi, Nazif; Dokmetas, Ilyas; Bakir, Mehmet; Ozdemir, Ozturk (ORTADOGU AD PRES & PUBL CO, 2009)Objective: The aim of this study was to investigate the role of multidrug transporter P-glycoprotein 1 (MDR1), cytochrome P450 isozyme 2D6 (CYP2D6) and C-C chemokine receptor 5 (CCR5) genes in the mortality of patients ...