Browsing Fakülteler by Author "49554685-9d54-4666-bf83-86d8fb2f7627"
Now showing items 1-15 of 15
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1, 2, 3-Triazole substituted phthalocyanine metal complexes as potential inhibitors for anticholinesterase and antidiabetic enzymes with molecular docking studies
Koçyiğit,Ümit M.; Taslimi, Parham; Tüzün,Burak; Yakan,Hasan; Muğlu, Halit; Güzel,Emre (Taylor & Francis, 2022/01/26)In recent years, acetylcholinesterase (AChE) and α-glycosidase (α-gly) inhibition have emerged as a promising and important approach for pharmacological intervention in many diseases such as glaucoma, epilepsy, obesity, ... -
Arylated quinoline and tetrahydroquinolines: Synthesis, characterization and their metabolic enzyme inhibitory and antimicrobial activities
Koçyiğit,Ümit M.; Ökten,Salih; Çakmak, Osman; Gizem, Burhan; Ataş,Mehmet; Taslimi, Parham; Gülçin,İlhami (Chemstry Europa, 2022/10/07)The aims of this study are to synthesize and characterize some new phenyl quinoline derivatives and to determine the activities of them and the recently prepared substituted phenyl quinolines against Acetylcholinesterase ... -
Biological effects and molecular docking studies of Catechin 5-O-gallate: Antioxidant, anticholinergics, antiepileptic and antidiabetic potentials
Taslimi, Parham; Koçyiğit,Ümit M.; Tüzün,Burak; Kirici,Mahinur (Taylor & Francis, 2022/04/13)Gallocatechin gallate is a form of catechin and an ester of gallocatechin and gallic acid. This is an epimer of the gallate epigallocatechin. In this study, the effect of this molecule, containing a biologically active ... -
Biologically active phthalocyanine metal complexes: Preparation, evaluation of α-glycosidase and anticholinesterase enzyme inhibition activities, and molecular docking studies
Güzel, Emre; Koçyiğit, Ümit M.; Taslimi, Parham; Erkan, Sultan; Taskin, Omer S. (Wiley, mart 2021)In this study, preparation, as well as investigation of α-glycosidase and cholinesterase (ChE) enzyme inhibition activities of furan-2-ylmethoxy-substituted compounds 1–7, are reported. Peripherally, tetra-substituted ... -
Biologically active phthalocyanine metal complexes: Preparation, evaluation of α‐glycosidase and anticholinesterase enzyme inhibition activities, and molecular docking studies
Güzel,Emre; Koçyiğit,Ümit M.; Taslimi, Parham; Erkan Sultan; Omer,Taskin S. (Wiley-VCH GmbH, Weinheim, 2021/6)In this study, preparation, as well as investigation of α‐glycosidase and cholinesterase (ChE) enzyme inhibition activities of furan‐2‐ylmethoxy‐substituted compounds 1–7, are reported. Peripherally, tetra‐substituted ... -
Cytotoxic effect, spectroscopy, DFT, enzyme inhibition, and moleculer docking studies of some novel mesitylaminopropanols: Antidiabetic and anticholinergics and anticancer potentials
Keklikcioğlu Çakmak, Neşe; N. Khalilov, Ali; Tüzün, Burak; Taslimi, Parham; Taş, Ayça; Tuncbilek, Zuhal (Elsevier, 09.10.2021)b-Amino alcohols (2–4) used in this study were re-synthesized in accordance with our previous study. All compounds were characterized by the combination of NMR, UV–Vis, IR experimental and theoretical spectral data. Then, ... -
Determination of biological studies and molecular docking calculations of isatin-thiosemicarbazone hybrid compounds
Koçyiğit,Ümit M.; Doğan, Murat; Muğlu, Halit; Taslimi, Parham; Tüzün,Burak; Yakan,Hasan; Bal, Halil; Güzel,Emre; Gülçin,İlhami (Elsevier, 2022/09/15)Design, synthesis, structural elucidation, and investigation of cytotoxic and antimicrobial activity, butyrylcholinesterase (BChE), and acetylcholinesterase (AChE) enzyme inhibition effects of isatinthiosemicarbazone ... -
In vitro cytotoxic effects, in silico studies, some metabolic enzymes inhibition, and vibrational spectral analysis of novel β-amino alcohol compounds
Tas, Ayca; Tüzün, Burak; N. Khalilov, Ali; Taslimi, Parham; Agbektas, Tuğba; Keklikcioğlu Çakmak, Neşe (2023)In this study, an efficient single-step method for the preparation of β-amino alcohols (1–3) in aqueous media was applied. The aim was to investigate the cytotoxic activity of Compounds 1, 2 and 3 in neuroblastoma SH-SY5Y ... -
In vitro cytotoxic effects, in silico studies, some metabolic enzymes inhibition, and vibrational spectral analysis of novel β-amino alcohol compounds
Tas, Ayca; Tüzün,Burak; Khalilov, Ali N; Taslimi, Parham; Agbektas, Tugba; Keklikcioglu Cakmak, Nese (Elsevier, 05.02.2023)In this study, an efficient single-step method for the preparation of β-amino alcohols ( 1 –3 ) in aqueous media was applied. The aim was to investigate the cytotoxic activity of Compounds 1, 2 and 3 in neu- roblastoma ... -
Phthalocyanine complexes with (4-isopropylbenzyl) oxy substituents: preparation and evaluation of anti-carbonic anhydrase, anticholinesterase enzymes and molecular docking studies
Güzel,Emre; Koçyiğit,Ümit M.; Taslimi, Parham; Gülçin,İlhami; Erkan Sultan; Nebioğlu, Mehmet; Arslan,Barış S; Şişman,İlkay (Taylor & Francis, 2022/01/26)n this study, the preparation, aggregation behavior and investigation of carbonic anhydrase and cholinesterase enzyme inhibition features of non-peripherally (4-isopropylbenzyl)oxy-substituted phthalocyanines (4–6) are ... -
Potential thiosemicarbazone-based enzyme inhibitors: Assessment of antiproliferative activity, metabolic enzyme inhibition properties, and molecular docking calculations
Yakan, Hasan; Koçyiğit, Ümit M.; Muğlu, Halit; Ergül, Mustafa; Erkan Sultan; Güzel, Emre; Taslimi, Parham; Gülçin, İlhami (Wiley, 2022)A new series of thiosemicarbazone derivatives (1–11) were prepared from various aldehydes and isocyanates with high yields and practical methods. The structures of these compounds were elucidated by Fourier transform ... -
Potential thiosemicarbazone-based enzyme inhibitors: Assessment of antiproliferative activity, metabolic enzyme inhibition properties, and molecular docking calculations
Yakan, Hasan; Koçyiğit, Ümit M.; Muğlu, Halit; Ergül, Mustafa; Erkan Sultan; Güzel, Emre; Taslimi, Parham; Gülçin, İlhami (Wiley, 2022)A new series of thiosemicarbazone derivatives (1–11) were prepared from various aldehydes and isocyanates with high yields and practical methods. The structures of these compounds were elucidated by Fourier transform ... -
Potential thiosemicarbazone‐based enzyme inhibitors: Assessment of antiproliferative activity, metabolic enzyme inhibition properties, and molecular docking calculations
Yakan,Hasan; Koçyiğit,Ümit M.; Muğlu, Halit; Ergul,Mustafa; Erkan,Sultan; Güzel,Emre; Taslimi, Parham; Gülçin,İlhami (Taylor & Francis, 2022/01/26)A new series of thiosemicarbazone derivatives (1–11) were prepared from various aldehydes and isocyanates with high yields and practical methods. The structures of these compounds were elucidated by Fourier transform ... -
Synthesis, molecular docking, and biological activities of new cyanopyridine derivatives containing phenylurea
Gezegen, Hayreddin; Gürdere, Meliha B.; Dinçer, Ayşegül; Özbek, Oğuz; Koçyiğit, Ümit M.; Taslimi, Parham; Tüzün, Burak; Budak, Yakup; Ceylan, Mustafa (2021)A new class of cyanopyridine derivatives (10a-e and 11a-e) containing the phenylurea unit was synthesized and tested against some metabolic enzymes including acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and ... -
Synthesis, molecular docking, and biological activities of new cyanopyridine derivatives containing phenylurea
Gezegen,Hayreddin; Gürdere,Meliha B.; Dinçer, Ayşegül; Özbek, Oğuz; Koçyiğit,Ümit M.; Taslimi, Parham; Tüzün,Burak; Budak,Yakup; Ceylan,Mustafa (Wiley-VCH GmbH, Weinheim, 2021/4)A new class of cyanopyridine derivatives (10a–e and 11a–e) containing the phenylurea unit was synthesized and tested against some metabolic enzymes including acetylcholinesterase (AChE), butyrylcholinesterase (BChE), ...