Browsing Sivas Cumhuriyet Üniversitesi Eczacılık Fakültesi by Author "Eczacılık Fakültesi"
Now showing items 101-118 of 118
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Synthesis, biological evaluation and in silico studies of novel thiadiazole-hydrazone derivatives for carbonic anhydrase inhibitory and anticancer activities
Eczacılık Fakültesi (04.08.2023)ABSTRACT Thiadiazole and hydrazone derivatives (5a–5i) were synthesized and their chemical structures were verified and described by 1 H NMR, 13 C NMR, and HRMS spectra. Three cancer cell lines (MCF-7, MDA, and ... -
Synthesis, Biological Evaluation and In Silico Studies of Some 2‐Substituted Benzoxazole Derivatives as Potential Anticancer Agents to Breast Cancer
In an attempt to develop potent and selective anticancer agents, some 5- or 6- and N-substituted benzoxazol-2-carbox amide derivatives were designed, synthesized, and evaluated for their cyclooxygenase inhibitory, antioxidant, ... -
Synthesis, carbonic anhydrase inhibitory activity, anticancer activity and molecular docking studies of new imidazolyl hydrazone derivatives
Tapera,Michael; Kekeçmuhammed, Hüseyin; Tüzün,Burak; Sarıpınar,Emin; Koçyiğit,Ümit M.; Yıldırım,Ebrar; Doğan, Murat; Zorlu, Yunus (Elsevier, 2022/12/05)A new series of imidazolyl hydrazone derivatives IA (1-12) were prepared from a condensation reaction between indoline-2,3-dione (isatin) and 2-benzylidenehydrazinecarboximidamide derivatives. The structure of compounds ... -
Synthesis, characterization, and application of polyacrylamide/carmine polymer nanomaterial as an effective solid-phase material for ultrasonic-assisted solid-phase microextraction of aluminum and chromium in vegetable samples
Here, a new and inexpensive polymer nanomaterial consisting of polyacrylamide and carmine (PAM-CR) was synthesized to provide selective extraction of aluminum and chromium from vegetable samples prior to their determination ... -
Synthesis, characterization, antimicrobial and antibiofilm activity, and molecular docking analysis of NHC precursors and their Ag-NHC complexes†
TUTAR, UĞUR; ÜSTÜN, ELVAN; ŞAHİN, NESLİHAN; ÇELİK, CEM; ÖZDEMİR, NAMIK; GÜRBÜZ, NEVİN; ÖZDEMİR, İSMAİL (The Royal Society, 2021)Microorganisms attach to surfaces and interfaces and form biofilms which create a sheltered area for host cell response. Therefore, biofilms provide troubles in fields such as medicine, food, and pharmaceuticals. Inhibition ... -
Synthesis, molecular docking, and biological activities of new cyanopyridine derivatives containing phenylurea
Gezegen,Hayreddin; Gürdere,Meliha B.; Dinçer, Ayşegül; Özbek, Oğuz; Koçyiğit,Ümit M.; Taslimi, Parham; Tüzün,Burak; Budak,Yakup; Ceylan,Mustafa (Wiley-VCH GmbH, Weinheim, 2021/4)A new class of cyanopyridine derivatives (10a–e and 11a–e) containing the phenylurea unit was synthesized and tested against some metabolic enzymes including acetylcholinesterase (AChE), butyrylcholinesterase (BChE), ... -
Synthesis, Molecular Docking, Dynamics, Quantum-Chemical Computation, and Antimicrobial Activity Studies of Some New Benzimidazole−Thiadiazole Hybrids
Çelik, İsmail; Çevik, Ulviye Acar; Karayel, Arzu; Işık, Ayşen; Kayış, Uğur; Gül, Ülküye Dudu; Bostancı, Hayrani Eren; Konca, Süheyl Furkan; Özkay, Yusuf; Kaplancıklı, Zafer Asım (ACS, 09.11.2022)In this study, some new compounds, which are 2aminothiadiazole derivatives linked by a phenyl bridge to the 2position of the benzimidazole ring, were designed and synthesized as antimicrobial agents. The structures of ... -
Tergitol@SiO2@Fe3O4 magnetic nano-material and experimental design methodology: An effective and selective adsorbent for solid phase microextraction and flame atomic absorption spectrometric analysis of lead in different matrixes
Altunay Nail; Elik Adil; Sarp,Gökhan; Ulusoy, Songül; Ulusoy, Halil İbrahim (Elsevier, 25.08.2021)In current paper, we synthesized a new and functional magnetic Tergitol@SiO2@Fe3O4. The synthesized magnetic nano-material was characterized in detail using transmission electron microscopy, energy dispersive spectrometer, ... -
Tetra-substituted phthalocyanines bearing thiazolidine derivatives: synthesis, anticancer activity on different cancer cell lines, and molecular docking studies
Bilgiçli, Ahmet T.; Hepokur, Ceylan; Genc Bilgicli, Hayriye; Tüzün, Burak; Mısır, Sema; Zengina, Mustafa; Yarasir, M. Nilüfer; Günsel, Armağan (2021)In the first step, (4R)-2-(2-hydroxyphenyl)thiazolidine-4-carboxylic acid (c) and 2-(2-(3,4-dicyano phenoxy)phenyl)thiazolidine-4-carboxylic acid (1) were prepared. Then, the peripherally tetra-substituted metallophthalocyanines ... -
The Effect of Vitamins on Oxidation in Experimentally Diabetes Conditioned Rats
Eczacılık Fakültesi (27.07.2023)Diabetes Mellitus (DM) is a metabolic disorder that is very common in our society, is caused by a combination of hereditary and environmental factors, and results in an increase in blood glucose levels. Diabetes mellitus ... -
The Role of Nitric Oxide Pathway in the Anti-Epileptogenic Effect of Valproic Acid in the Pentylenetetrazole-Kindling Model in Rats
Bilal Sahin; Ahmet Kemal Filiz; Ziad Joha (02. 06. 20)Though valproic acid (VPA) is used to treat seizures, more investigations have been needed to understand the effect of VPA on the nitric oxide pathway in epilepsy. Our investigation aimed to study the effect of VPA on ... -
The synthesis and characterization of iron nanoparticles with lemon peel and its use in magnetic solid phase extraction for trace levels of lead (II)
Çakmak, Emre; Oymak, Tülay (Springer, 03/03/2022)In this study, a new magnetic solid phase extraction method (MSPE) was developed for the enrichment and separation of trace amount Pb(II) on the magnetic nanoparticles synthesized using lemon peel ( Fe3O4-LP). The ... -
Use of Fe3O4@ MPTMS-Dithizone Magnetic Nanoparticles as Solid Phase Sorbent for Sensitive Analysis of Sibutramine Molecules in Herbal Slimming Products.
Background: A new enrichment and sensitive determination method, which includes HPLCDAD analysis after Magnetic Solid Phase Extraction (MSPE), has been developed for trace analysis of Sibutramine molecules in herbal ... -
Use of Fe3O4@MPTMS-Dithizone Magnetic Nanoparticles as Solid Phase Sorbent for Sensitive Analysis of Sibutramine Molecules in Herbal Slimming Products
Özge Demir; Halil İbrahim Ulusoy; Ümmügülsüm Polat; Songül Ulusoy (Bentham Science Publishers, June 07, 2)Abstract: Background: A new enrichment and sensitive determination method, which includes HPLCDAD analysis after Magnetic Solid Phase Extraction (MSPE), has been developed for trace analysis of Sibutramine molecules in ... -
Use of newly synthetized magnetic Fe3O4 nanoparticles modified with hexadecyl trimethyl ammonium bromide for the sensitive analysis of antidepressant drugs, duloxetine and vilazodone in wastewater and urine samples
A new enrichment and determination method involving HPLC-DAD analysis following magnetic solidphase extraction (MSPE) was developed to detect trace amounts of two antidepressant drugs, namely, duloxetine (DUL) and ... -
Use of newly synthetized magnetic Fe3O4 nanoparticles modified with hexadecyl trimethyl ammonium bromide for the sensitive analysis of antidepressant drugs, duloxetine and vilazodone in wastewater and urine samples
Halil Ibrahim Ulusoy; Ummugulsum Polat; Songül Ulusoy (RSC, 17th June )A new enrichment and determination method involving HPLC-DAD analysis following magnetic solidphase extraction (MSPE) was developed to detect trace amounts of two antidepressant drugs, namely, duloxetine (DUL) and ... -
Vitamin D increases the efcacy of cisplatin on bladder cancer cell lines
Özgen,Özge; Eroğlu,Güneş Özen; Küçükhüseyin,Özlem; Akdeniz,Nilgün; Hepokur,Ceylan; Kuruca,Serap; Yaylım,İlhan (2023)Background 1,25(OH)2D3(Calcitriol), which is a broad regulatory molecule, plays a role in changing the efcacy of chemo therapeutic drugs. Cisplatin is one of a current standard chemotherapy regimen for bladder cancer. ... -
What Are Polymeric Carriers?
Karakuş, Gülderen (CRC Press Taylor&Francis Group, 2021)High technology advances in polymer science have opened up new opportunities in drug delivery systems. This chapter broadens the existing information in the field of polymeric materials and polymeric carriers for drug ...