Browsing Sivas Cumhuriyet Üniversitesi Eczacılık Fakültesi by Author "Eczacılık Fakültesi"
Now showing items 21-40 of 118
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BSA/DNA binding behavior and the photophysicochemical properties of novel water soluble zinc (II) phthalocyanines directly substituted with piperazine groups
Khezami, Khaoula; Harmandar, Kevser; Bağda, Esra; Bağda, Efkan; Şahin, Gamze; Karakodak, Nurşen; Durmuş, Mahmut (2021/6)In the current research, two novel zinc(II) phthalocyanines (ZnPcs) (1 and 2) directly connecting with 4-(4-methylpiperazin-1-yl)phenyl groups have been synthesized through the Suzuki–Miyaura coupling reaction. These ZnPcs ... -
circRNAs in drug resistance of breast cancer
Mısır, Sema; YAMAN, SERAP OZER; PETROVIĆ,NINA; SUMER,CEREN; HEPOKUR, CEYLAN; ALIYAZICIOGLU,YUKSEL (2022)Abstract: Breast cancer (BC) is the most common heterogeneous disease in women and one of the leading causes of cancer-related death. Surgery, chemotherapy, radiotherapy, hormone, and targeted therapy are the gold standards ... -
Circulating serum miR-200c and miR-34a-5p as diagnostic biomarkers for endometriosis
Misir, Sema; Hepokur, Ceylan; Oksasoglu, Bugra; Yildiz, Caglar; Yanik, Ali; Aliyazicioglu,Yüksel (2021)Objective: Endometriosis is defined by the presence of endometrial glands and stroma grow in areas outside the uterus. A simple blood test for endometriosis-specific biomarkers would offer a more timely accurate diagnosis ... -
Comparative analysis of pre-fermentation treatments on phenolic compounds and bioactivity in Vitis Vinifera var. Syrah and var. Cabernet Sauvignon grapes
Sönmez Gürer, Eda; Ghanem Chantel; Bouajila Jalloul; Rizk Ziad; Beyrouthy Marc El; Sadaka Carmen; Souchard Jean Pierre; Taillandier Patricia; Sharifi-Rad Javad; Nehme Nancy; Rayess Youssef El (Mayıs 2023)This study investigated the effect of pre-fermentation treatments on the phenolic compounds and biological activities of red grapes of Vitis vinifera var. Syrah and var. Cabernet Sauvignon Syrah and Cabernet sauvignon musts ... -
Comparison of Chemical Profiles of Aronia melanocarpa Fruit Extracts
Karadağ, Ayşe Esra; Altıntaş, Ayhan; Sönmez Gürer, Eda (Şubat 2023)The chokeberry plant, which is native to North America and the south of Canada, is a deciduous, shrub-shaped, berry-like plant belonging to the Rosaceae family, which survives for many years. It is seen as a plant that ... -
Composition characterization and biological activity study of Achillea vermicularis extract and extract‐loaded nanoparticles
Murat Doğan; Ümit M Koçyiğit; Feyza Nur Çetin; Beyza Nur Yılmaz; Turgut Taşkın (JUMB, 2023/1/9)Antiproliferative activity of Achillea vermicularis extracts was calculated on glial (C6) and keratinocyte (HaCaT) cell lines using XTT assay. It was observed that all extracts of A. vermicularis at the determined concentration ... -
Decolourization of Methylene Blue in Aqueous Solution by Photocatalytic Oxidation, Fenton Oxidation and Biosorption
Kartal Temel, Nuket; Bağda, Esra (Cumhuriyet Science Journal, 27.12.2022)The aim of the study was to investigate decolourization of Methylene Blue (MB) in aqueous solution using advanced oxidation processes (AOPs) and biosorption comparatively. Photocatalytic decolourization of MB was studied ... -
Decoration, Characterization and Antimicrobial Activity Evaluation of Novel Nano-Based 1,2-Phenylenediamine Functionalized Maleic Anhydride-Allylphenyl Ether Conjugate
Karakus Gülderen; Atas Mehmet (Chemistry Europe, 02 October)1,2-Phenylenediamine (o-PDA) is a well-known fluorescent dye that enables the decoration of next generation chemotherapeutics. A novel o-PDA-functionalized maleic anhydride-allyl phenyl ether (poly(MA-alt-APE)/o-PDA ... -
Design and in vitro in vivo evaluation of antioxidant bioadhesive gels for burn treatment
Gökçe, Göksel; Karavana, Sinem Yaprak; Bağrıyanık, Hüsnü Alper; Pekçetin, Çetin; Alğın Yapar, Evren; Aybar Tural, Gülşen; Gökçe, Evren Homan. (TUBİTAK, 2022)Abstract Burn wounds are frequently encountered health problems, which need a new treatment approach especially in terms of good patient compliance. Availability of use of antioxidant agents and bio-adhesive gels in tissue ... -
Design, synthesis and biological evaluation of novel bischalcone derivatives as potential anticancer agents
Burmalıoğlu Serdar; Göbek, Arzu; Özturk Aydın,Busra; Yurtoğlu, Emine; Nur Aydın,Busra; Yalcin Ozkat,Gozde; Hepokur, Ceylan; Şimşek Özek, Nihal; Ayşin, Ferhunde; Altundas, Ramazan; Algul,Oztekin (1April 202)Building on our previous work that discovered chalcone as a promising pharmacophore for anticancer activity, we have various other chalcone derivatives and have synthesized a series of novel bischalcone to explore their ... -
Design, synthesis and biological evaluation of novel ketone derivatives containing benzimidazole and 1,3,4-triazole as CA inhibitors
ACAR ÇEVİK ULVİYE; Işık Ayşen; Kapavarapu Ravikumar; KÜÇÜKOĞLU KAAN; NADAROĞLU HAYRUNNİSA; BOSTANCI HAYRANİ EREN; ÖZKAY YUSUF; KAPLANCIKLI ZAFER ASIM (03.10.2023)In this study, we synthesized a series of new benzimidazole-triazole (6a-6k) derivatives and characterized them by 1 H NMR, 13C NMR, and HRMS. These compounds were evaluated for their inhibitory activity against hCA-I and ... -
Design, synthesis and in vitro antiproliferation activity of some 2-aryl and -heteroaryl benzoxazole derivatives
Background: Phortress produces reactive electrophilic metabolites that form DNA adducts only in sensitive tumor cells. The authors converted the 2-phenylbenzothiazole nucleus in phortress to 2- aryl and -heteroaryl ... -
Design, synthesis and molecular docking studies of novel benzimidazole-1,3,4-oxadiazole hybrids for their carbonic anhydrase inhibitory and antioxidant effects
Küçükoğlu, Kaan; Çevik, Ulviye Acar; Nadaroğlu, Hayrunnisa; Çelik, İsmail; Işık, Ayşen; Bostancı, Hayrani Eren; Özkay, Yusuf; Kaplancıklı, Zafer Asım (Medicinal Chemistry Research, 08.08.2022)In this study, eleven new compounds with a series of benzimidazole-1,3,4-oxadiazole derivatives structures were synthesized and evaluated for their human (h) carbonic anhydrase inhibitory activities against two isoforms ... -
Determination of biological studies and molecular docking calculations of isatin-thiosemicarbazone hybrid compounds
Koçyiğit,Ümit M.; Doğan, Murat; Muğlu, Halit; Taslimi, Parham; Tüzün,Burak; Yakan,Hasan; Bal, Halil; Güzel,Emre; Gülçin,İlhami (Elsevier, 2022/09/15)Design, synthesis, structural elucidation, and investigation of cytotoxic and antimicrobial activity, butyrylcholinesterase (BChE), and acetylcholinesterase (AChE) enzyme inhibition effects of isatinthiosemicarbazone ... -
Determination of chloramphenicol and tetracycline residues in milk samples by means of nanofiber coated magnetic particles prior to high-performance liquid chromatography-diode array detection
Vuran, Büşra; Ulusoy, Halil İbrahim; Sarp,Gökhan; Ulusoy, Songül; Morgül, Ümmügülsüm; Kabir,Abuzar; Tartaglia, Angela; Locatelli, Marcello; Soylak, Mustafa (Elsevier, 08.03.2021)A magnetic solid phase extraction (MSPE) coupled with high-performance liquid chromatography-diode array detection (HPLC-DAD) methodology was developed for the determination of chloramphenicol (CP) and tetracycline (TET) ... -
Determination of phenolic compounds in human saliva after oral administration of red wine by high performance liquid chromatography
Tartaglia, Angela; Romasco, T; D’Ovidio, Cristian; Rosato, Enrica; Ulusoy, Halil İbrahim; Furton.G, Kenneth; Kabir,Abuzar; Locatelli, Marcello (Elsevier, 05.02.2022)Search ScienceDirect Outline Highlights Abstract Keywords 1. Introduction 2. Materials and methods 3. Results and discussion 4. Conclusions Declaration of Competing Interest Acknowledgments Appendix A. Supplementary ... -
Determination of Sulfadiazine in Natural Waters by Pine Needle Biochar - Derivatized Magnetic Nanocomposite Based Solid-Phase Extraction (SPE) with High-Performance Liquid Chromatography (HPLC)
Remziye Nur Avcı, Tülay Oymak, Esra Bagda (Taylor&Francis, 26/03/2022)A magnetic solid-phase extraction (MSPE) method was developed for the facile and sensitive determination of sulfadiazine prior to high-performance liquid chromatography (HPLC) analysis. The magnetic sorbent was prepared ... -
Determination of sunset yellow, allura red, and fast green using a novel magnetic nanoadsorbent modified with Elaeagnus angustifolia based on magnetic solid-phase extraction by HPLC
Tülay Oymak, Emrah Dural (UNIV SAO PAULO, CONJUNTO QUIMICAS, 2022)Sunset yellow (SY), allura red (AR) and fast green (FG) are frequently used in commercial food products, although they are considered to be hazardous to public health due to their toxic efficacy and high exposure risk ... -
Development of quantum dot-phthalocyanine integrated G-quadruplex /double-stranded DNA biosensor
Topcu, Ayşe; Bağda, Esra; Oymak, Tülay; Durmuş, Mahmut (Elsevier, 2022)In the present study, the phthalocyanine (Pc) integrated mercaptopropionic acid capped quantum dot (mpa@QD) biosensor has been developed for the quantitative determination of G-quadruplex and doublestranded DNA. The ... -
Development of quantum dot-phthalocyanine integrated G-quadruplex/double-stranded DNA biosensor
Topcu, Ayşe; Bağda, Esra; Oymak, Tülay; Durmuş, Mahmut (1 October )n the present study, the phthalocyanine (Pc) integrated mercaptopropionic acid capped quantum dot (mpa@QD) biosensor has been developed for the quantitative determination of G-quadruplex and double-stranded DNA. The working ...