Browsing Sivas Cumhuriyet Üniversitesi Eczacılık Fakültesi by Author "Eczacılık Fakültesi"
Now showing items 61-80 of 118
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Isatin/thiosemicarbohydrazone hybrids: Facile synthesis, and their evaluation as anti-proliferatıve agents and metabolıc enzyme inhibitors
Hasan Yakan; Mohammed Azam; Sevgi Kansız; Halit Muğlu; Mustafa Ergül; Parham Taslimi; Ümit M Koçyiğit; Muhammet Karaman; Saud I Al-Resayes; Kim Min (AJOL, 2023/7/3)We are reporting a novel series of thiosemicarbazone derivatives derived from isatin (1-6), structural determination, and investigation of the inhibitory properties against proliferative, carbonic anhydrase, and cholinesterase ... -
Magnetic solid-phase extraction coupled to high-performance liquid chromatography (HPLC)-diode array detection method has been developed for the sensitive analysis of Anastrozole (ANA) and Letrozole (LET) in human urine samples. Characterization studies of the newly synthesized material (Fe3O4@TEPA) were carried out by Fourier-transform infrared spectroscopy (FTIR), X-ray diffraction, Raman spectroscopy, and scanning electron microscope techniques. The method has provided linearity for both the analytes (r2 > 0.9900) in the range of 4.00–160.00 ng mL−1. The limit of detections for ANA and LET was found to be 1.14 and 1.26 ng mL−1, respectively. The limit of quantification for ANA and LET was obtained 3.78 and 3.86 ng mL−1, respectively. The new method was simple, convenient, fast, and suitable for the direct analysis of ANA and LET in urine samples. Finally, the developed method was applied to the spiked human urine samples to test accuracy and repeatability. Recovery values for each of the molecules were calculated in the range of 93.4–108.0% (n = 3) at two concentration levels, while % RSDs were lower than 6.2%. Graphical abstract
Şimşek, Selçuk; Kaya Savaş; Şenol, Zeynep Mine; Ulusoy, Halil İbrahim; Katim, Kp; Özer, Ali; Altunay Nail; Brahmia, Ameni (Elsevier, 15.04.2022)A new Polyacrylamide (PAA)-Vermiculite (V) composite was synthesized and characterized with the help of FTIR, SEM, and PZC analyses. The effects of ion concentration, pH and ionic strength parameters to adsorption process ... -
Mechanism of anticancer effect of ETP‑45658, a PI3K/AKT/mTOR pathway inhibitor on HT‑29 Cells
Fatih Yulak; Ahmet Kemal Filiz; Ziad Joha; Mustafa Ergul (27. 10. 20)The PI3K pathway plays a crucial role in tumor cell proliferation across various cancers, including colon cancer, making it a promising treatment target. This study aims to investigate the antiproliferative activity of ... -
Mechanism of anticancer effect of gambogic acid on gastric signet ring cell carcinoma
Ziad Joha; Ayşegül Öztürk; Fatih Yulak; Özhan Karataş; Hilmi Ataseven (16. 08. 20)Gambogic acid has demonstrated inhibitory effects on the growth of various cancer cell types, such as breast cancer, pancreatic cancer, prostate cancer, lung cancer, and osteosarcoma. This study aims to investigate the ... -
Michael/Michael Addition Cascade of 2-Benzylidene-1- indanones with Chalcones: Synthesis and Biological Evaluations of Novel Polycyclic Compounds
TUTAR, UĞUR; GEZEGEN, HAYREDDİN; CEYLAN, HEPOKUR; TÜZÜN, GAMZE; ATİOĞLU, ZELİHA; AKKURT, MEHMET (WİLLEY ONLİNE LİBRARY, 2021)A series of novel racemic 2-aryloyl-1,3-diaryl-2,3,3a,8a-tetrahydrocyclopenta[ a]inden-8(1H)-one derivatives were synthesized from KOtBu mediated Michael/Michael addition reaction of 2- benzylidene-1-indanones with ... -
Michael/Michael Addition Cascade of 2-Benzylidene-1- indanones with Chalcones: Synthesis and Biological Evaluations of Novel Polycyclic Compounds
Gezegen,Hayreddin; Tutar, Uğur; Hepokur, Ceylan; Tüzün, Gamze; Atioğlu,Zeliha; Akkurt, Mehmet (2021)A series of novel racemic 2-aryloyl-1,3-diaryl-2,3,3a,8a-tetrahy drocyclopenta[a]inden-8(1H)-one derivatives were synthesized from KOtBu mediated Michael/Michael addition reaction of 2- benzylidene-1-indanones with ... -
Molecular hybrids integrated with imidazole and hydrazone structural motifs: Design, synthesis, biological evaluation, and molecular docking studies
Michael Tapera; Hüseyin Kekeçmuhammed; Emin Sarıpınar; Murat Doğan; Burak Tüzün; Ümit M Koçyiğit; Feyza Nur Çetin (Elsevier, 2023/12/1)In the present work, a series of compounds containing imidazole and hydrazone structural frameworks were synthesized and characterized using various spectral techniques, including 1H NMR, 13C NMR, FTIR, and HRMS. Synthesized ... -
Nanocomposite smart hydrogel based on sepiolite nanochannels/N-isopropyl acrylamide/itaconic acid/acrylamide for invertase immobilization
Novel nanocomposite smart hydrogel (NSH) and smart hydrogel (SH) are prepared to be used as a support for invertase. Spectrophotometric and thermal analysis methods were used for the characterization. Lower critical ... -
Nekroz
Eczacılık Fakültesi (31.12.2023)Nekroz, hücrenin ani bir şok (radyasyon, ısı, kimyasallar, hipoksi, iskemi vb.), mekanik stres gibi şiddetli çevresel bozulmalar ve donma-çözülme sonrası gibi ciddi şekilde hasar gördüğü, enerjiden bağımsız bir hücre ... -
New Fluoro- and Trifluoromethyl-Substituted Trimethoxychalcones as Anticancer Agents: Synthesis, Bioevaluation, and Computational Studies
Polat,M. Fatih; Aktas Anil, Derya; Ozkemahli,Gizem; Turkmenoglu, Burcin; Hepokur,Ceylan; Burmaoglu,Serdar; Algul,Oztekin (2023)We designed and synthesized a novel series of trimethoxy chalcones with CF3 or F substituents at various positions of ring B, characterized using IR, NMR spectral data, and elemental analyses, based on the fact that ... -
New imidazole derivatives as aromatase inhibitor: Design, synthesis, biological activity, molecular docking, and computational ADME-Tox studies
Eczacılık Fakültesi (06.01.2023)In this study, a series of imidazole derivatives was designed, synthesized, and evaluated for in vitro bi- ological activity on the human breast cancer cell line MCF7 by MTT assay. To determine the selectivity of the ... -
Novel Applications of Microextraction Techniques Focused on Biological and Forensic Analyses
D’Ovidio, Cristian; Bonelli, Martina; Rosato, Enrica; Tartaglia, Angela; Ulusoy, Halil İbrahim; Samadiou, Victoria; Furton.G, Kenneth; Kabir,Abuzar; Ali, İmran; Savini, Fabio; Locatelli, Marcello; Grazia, Ugo (MDPI, 15.02.2022)In recent years, major attention has been focused on microextraction procedures that allow high recovery of target analytes, regardless of the complexity of the sample matrices. The most used techniques included liquid-liquid ... -
Novel Bioactive Glass/Graphene Oxide-Coated Surgical Sutures for Soft Tissue Regeneration
The combination of a commercially available PGLA (poly[glycolide-co-L-lactide]), 90:10% suture material with bio active bioglass nanopowders (BGNs) and graphene oxide (GO)- doped BGNs offers new opportunities for the ... -
Novel ultra-stretchable and self-healing crosslinked poly (ethylene oxide)-cationic guar gum hydrogel
Sönmez Gürer, Eda; Alberto Bernal‑Chávez, Sergio; Alcalá‑Alcalá Sergio; M. Almarhoon, Zainab; Turgumbayeva, Aknur; De Los Dolores, Campos‑Echeverria Ma; Cortes, Hernan; Romero‑Montero, Alejandra; Del Prado‑Audelo9, Maria Luise; Sharifi-Rad Javad; Leyva‑Gómez Gerardo (Ekim 2023)AbstractHydrogels are three-dimensional structures with specific features that render them useful for biomedical applications, such as tissue engineering scaffolds, drug delivery systems, and wound dressings. In recent ... -
One-pot modification of oleate-capped UCNPs with AS1411 G-quadruplex DNA in a fully aqueous medium
Bağda, Esra; Kızılyar, Yiğit; Gülüm İnci, Özlem; Ghaffarlou, Mohammadreza; Barsbay, Murat (5 June 202)In the present work, modification of oleate-capped upconverting nanoparticles (OA@UCNPs) with AS1411 G-quadruplex DNA by a one-pot aqueous strategy was presented. The G-quadruplex structure of AS1411 and structural alterations ... -
Pharmaco-Metabolomics: Drug Effects on Metabolites
Sönmez Gürer, Eda (Nova Science Publishers, 2023)The development and advancements in technology, artificial intelligence, and fields of bioinformatics, enabled the use of enormous data coming from genes, transcripts, and proteins processed by the omics in medicine as ... -
Pharmacokinetic Profiles of Metamizole Metabolites after Intramuscular and Intravenous Administration in Healthy Arabian Horses
Yılmaz, İsmet; Maraş,Zeynep; Uğur, Yılmaz; Özgür, Mustafa Erkan; Durmaz, Murat; Ulusoy, Halil İbrahim; Erdoğan, Selim (2021)Metamizole sodium (MT) is an analgesic and antipyretic drug molecule used in humans, horses, cattle, swine, and dogs. Metamizole rapidly hydrolyzes and turns into methyl amino antipyrine (MAA), an active primary metabolite ... -
Phenolic content, antioxidant and antimicrobial activities evaluation and relationship of commercial spices in the lebanese market
Sönmez Gürer, Eda; Rayess, Youssef El; Nehme, Lea; Ghanem, Chantal; Beyrouthy, Marc El; Sadaka, Carmen; Azzi-Achkouty, Samar; Nehme, Nancy; Sharifi-Rad, Javad (Kasım 2023)AbstractLebanese cuisine is renowned for its distinctive flavours and vibrant aromas. In Lebanese cuisine, spices are not just used for their flavour; they are also valued for their medicinal properties. This study consists ... -
Phthalocyanine complexes with (4-isopropylbenzyl) oxy substituents: preparation and evaluation of anti-carbonic anhydrase, anticholinesterase enzymes and molecular docking studies
Güzel,Emre; Koçyiğit,Ümit M.; Taslimi, Parham; Gülçin,İlhami; Erkan Sultan; Nebioğlu, Mehmet; Arslan,Barış S; Şişman,İlkay (Taylor & Francis, 2022/01/26)n this study, the preparation, aggregation behavior and investigation of carbonic anhydrase and cholinesterase enzyme inhibition features of non-peripherally (4-isopropylbenzyl)oxy-substituted phthalocyanines (4–6) are ... -
Piperazin incorporated Schiff Base derivatives: Assessment of in vitro biological activities, metabolic enzyme inhibition properties, and molecular docking calculations
Arif Mermer; Burak Tüzün; Sevgi Durna Daştan; Ümit M Koçyiğit; Feyza Nur Çetin; Özge Çevik (WİLEY, 2023/11)The cytotoxic activities of the compounds were determined by the 3‐(4, 5‐dimethylthiazolyl‐2)‐2,5‐diphenyltetrazolium bromide (MTT) method in human breast cancer (MCF‐7), human cervical cancer (HeLa), and mouse fibroblast ...