Browsing Sivas Cumhuriyet Üniversitesi Eczacılık Fakültesi by Title
Now showing items 76-95 of 135
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Mechanism of anticancer effect of gambogic acid on gastric signet ring cell carcinoma
(16. 08. 20)Gambogic acid has demonstrated inhibitory effects on the growth of various cancer cell types, such as breast cancer, pancreatic cancer, prostate cancer, lung cancer, and osteosarcoma. This study aims to investigate the ... -
Michael/Michael Addition Cascade of 2-Benzylidene-1- indanones with Chalcones: Synthesis and Biological Evaluations of Novel Polycyclic Compounds
(WİLLEY ONLİNE LİBRARY, 2021)A series of novel racemic 2-aryloyl-1,3-diaryl-2,3,3a,8a-tetrahydrocyclopenta[ a]inden-8(1H)-one derivatives were synthesized from KOtBu mediated Michael/Michael addition reaction of 2- benzylidene-1-indanones with ... -
Michael/Michael Addition Cascade of 2-Benzylidene-1- indanones with Chalcones: Synthesis and Biological Evaluations of Novel Polycyclic Compounds
(2021)A series of novel racemic 2-aryloyl-1,3-diaryl-2,3,3a,8a-tetrahy drocyclopenta[a]inden-8(1H)-one derivatives were synthesized from KOtBu mediated Michael/Michael addition reaction of 2- benzylidene-1-indanones with ... -
Molecular hybrids integrated with imidazole and hydrazone structural motifs: Design, synthesis, biological evaluation, and molecular docking studies
(Elsevier, 2023/12/1)In the present work, a series of compounds containing imidazole and hydrazone structural frameworks were synthesized and characterized using various spectral techniques, including 1H NMR, 13C NMR, FTIR, and HRMS. Synthesized ... -
Nanocomposite smart hydrogel based on sepiolite nanochannels/N-isopropyl acrylamide/itaconic acid/acrylamide for invertase immobilization
(2021)Novel nanocomposite smart hydrogel (NSH) and smart hydrogel (SH) are prepared to be used as a support for invertase. Spectrophotometric and thermal analysis methods were used for the characterization. Lower critical ... -
Nekroz
(31.12.2023)Nekroz, hücrenin ani bir şok (radyasyon, ısı, kimyasallar, hipoksi, iskemi vb.), mekanik stres gibi şiddetli çevresel bozulmalar ve donma-çözülme sonrası gibi ciddi şekilde hasar gördüğü, enerjiden bağımsız bir hücre ... -
New benzimidazole‐oxadiazole derivatives: Synthesis, α‐glucosidase, α‐amylase activity, and molecular modeling studies as potential antidiabetic agents
(23.01.2023)Benzimidazole‐1,3,4‐oxadiazole derivatives (5a–z) were synthesized and characterized with different spectroscopic techniques such as 1 HNMR, 13 CNMR,andHRMS.The synthesized analogs were examined against α‐glucosidase ... -
New Fluoro- and Trifluoromethyl-Substituted Trimethoxychalcones as Anticancer Agents: Synthesis, Bioevaluation, and Computational Studies
(2023)We designed and synthesized a novel series of trimethoxy chalcones with CF3 or F substituents at various positions of ring B, characterized using IR, NMR spectral data, and elemental analyses, based on the fact that ... -
New imidazole derivatives as aromatase inhibitor: Design, synthesis, biological activity, molecular docking, and computational ADME-Tox studies
(06.01.2023)In this study, a series of imidazole derivatives was designed, synthesized, and evaluated for in vitro bi- ological activity on the human breast cancer cell line MCF7 by MTT assay. To determine the selectivity of the ... -
Novel Applications of Microextraction Techniques Focused on Biological and Forensic Analyses
(MDPI, 15.02.2022)In recent years, major attention has been focused on microextraction procedures that allow high recovery of target analytes, regardless of the complexity of the sample matrices. The most used techniques included liquid-liquid ... -
Novel Bioactive Glass/Graphene Oxide-Coated Surgical Sutures for Soft Tissue Regeneration
(2023)The combination of a commercially available PGLA (poly[glycolide-co-L-lactide]), 90:10% suture material with bio active bioglass nanopowders (BGNs) and graphene oxide (GO)- doped BGNs offers new opportunities for the ... -
Novel ultra-stretchable and self-healing crosslinked poly (ethylene oxide)-cationic guar gum hydrogel
(Ekim 2023)AbstractHydrogels are three-dimensional structures with specific features that render them useful for biomedical applications, such as tissue engineering scaffolds, drug delivery systems, and wound dressings. In recent ... -
One-pot modification of oleate-capped UCNPs with AS1411 G-quadruplex DNA in a fully aqueous medium
(5 June 202)In the present work, modification of oleate-capped upconverting nanoparticles (OA@UCNPs) with AS1411 G-quadruplex DNA by a one-pot aqueous strategy was presented. The G-quadruplex structure of AS1411 and structural alterations ... -
Pharmaco-Metabolomics: Drug Effects on Metabolites
(Nova Science Publishers, 2023)The development and advancements in technology, artificial intelligence, and fields of bioinformatics, enabled the use of enormous data coming from genes, transcripts, and proteins processed by the omics in medicine as ... -
Pharmacokinetic Profiles of Metamizole Metabolites after Intramuscular and Intravenous Administration in Healthy Arabian Horses
(2021)Metamizole sodium (MT) is an analgesic and antipyretic drug molecule used in humans, horses, cattle, swine, and dogs. Metamizole rapidly hydrolyzes and turns into methyl amino antipyrine (MAA), an active primary metabolite ... -
Phenolic content, antioxidant and antimicrobial activities evaluation and relationship of commercial spices in the lebanese market
(Kasım 2023)AbstractLebanese cuisine is renowned for its distinctive flavours and vibrant aromas. In Lebanese cuisine, spices are not just used for their flavour; they are also valued for their medicinal properties. This study consists ... -
Phthalocyanine complexes with (4-isopropylbenzyl) oxy substituents: preparation and evaluation of anti-carbonic anhydrase, anticholinesterase enzymes and molecular docking studies
(Taylor & Francis, 2022/01/26)n this study, the preparation, aggregation behavior and investigation of carbonic anhydrase and cholinesterase enzyme inhibition features of non-peripherally (4-isopropylbenzyl)oxy-substituted phthalocyanines (4–6) are ... -
Piperazin incorporated Schiff Base derivatives: Assessment of in vitro biological activities, metabolic enzyme inhibition properties, and molecular docking calculations
(WİLEY, 2023/11)The cytotoxic activities of the compounds were determined by the 3‐(4, 5‐dimethylthiazolyl‐2)‐2,5‐diphenyltetrazolium bromide (MTT) method in human breast cancer (MCF‐7), human cervical cancer (HeLa), and mouse fibroblast ... -
Plant‑inspired adhesive and injectable natural hydrogels: in vitro and in vivo studies
(2023)The development of alternative thera peutic treatments based on the use of medicinal and aromatic plants, such as Juniper communis L., has aroused interest in the medical feld to fnd new alter natives to conventional ... -
Poli[Maleik Anhidrit-Ko-Vinil Asetat] Kopolimerinin Doksorubisin/Doksorubisin Türevi Antikanser İlaçlarla Doğrusal Rasyonel Konjugatlarının Sentezi, Yapısal Karakterizasyonları Ve Çeşitli Kanser Hücreleri Üzerinde Sitotoksik/Antikanser Aktiviteleri
(20.01.2022)Nanotoksik özellikli poli[Maleik Anhidrit-Ko-Vinil Asetat] kopolimerinin sentezlenmesinden sonra ilaçlar tr için iyi bir taşıyıcı olduğu çeşitli deneysel veri ve analizlerle kanıtlanmıştır. Doksorubisin/Doksorubisin türevi ...