Browsing Sivas Cumhuriyet Üniversitesi Eczacılık Fakültesi by Author "Güzel,Emre"
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1, 2, 3-Triazole substituted phthalocyanine metal complexes as potential inhibitors for anticholinesterase and antidiabetic enzymes with molecular docking studies
Koçyiğit,Ümit M.; Taslimi, Parham; Tüzün,Burak; Yakan,Hasan; Muğlu, Halit; Güzel,Emre (Taylor & Francis, 2022/01/26)In recent years, acetylcholinesterase (AChE) and α-glycosidase (α-gly) inhibition have emerged as a promising and important approach for pharmacological intervention in many diseases such as glaucoma, epilepsy, obesity, ... -
Determination of biological studies and molecular docking calculations of isatin-thiosemicarbazone hybrid compounds
Koçyiğit,Ümit M.; Doğan, Murat; Muğlu, Halit; Taslimi, Parham; Tüzün,Burak; Yakan,Hasan; Bal, Halil; Güzel,Emre; Gülçin,İlhami (Elsevier, 2022/09/15)Design, synthesis, structural elucidation, and investigation of cytotoxic and antimicrobial activity, butyrylcholinesterase (BChE), and acetylcholinesterase (AChE) enzyme inhibition effects of isatinthiosemicarbazone ... -
Evaluation of the effects of newly synthesized metallophthalocyanines on breast cancer cell lines with photodynamic therapy
Bostancı,Hayrani Eren; Bilgiçli, Ahmet T.; Güzel,Emre; Günsel,Armağan; Hepokur, Ceylan; Çimen,Behzat; Yarasir,M. Nilüfer (2022)In this study, the new phthalonitrile derivative 3-(4-(3-oxobutyl)phenoxy)phthalonitrile (1) and its non peripheral metallophthalocyanine derivatives [zinc (2), copper (3), cobalt (4), manganese (5), gallium (6), and ... -
Phthalocyanine complexes with (4-isopropylbenzyl) oxy substituents: preparation and evaluation of anti-carbonic anhydrase, anticholinesterase enzymes and molecular docking studies
Güzel,Emre; Koçyiğit,Ümit M.; Taslimi, Parham; Gülçin,İlhami; Erkan Sultan; Nebioğlu, Mehmet; Arslan,Barış S; Şişman,İlkay (Taylor & Francis, 2022/01/26)n this study, the preparation, aggregation behavior and investigation of carbonic anhydrase and cholinesterase enzyme inhibition features of non-peripherally (4-isopropylbenzyl)oxy-substituted phthalocyanines (4–6) are ... -
Potential thiosemicarbazone‐based enzyme inhibitors: Assessment of antiproliferative activity, metabolic enzyme inhibition properties, and molecular docking calculations
Yakan,Hasan; Koçyiğit,Ümit M.; Muğlu, Halit; Ergul,Mustafa; Erkan,Sultan; Güzel,Emre; Taslimi, Parham; Gülçin,İlhami (Taylor & Francis, 2022/01/26)A new series of thiosemicarbazone derivatives (1–11) were prepared from various aldehydes and isocyanates with high yields and practical methods. The structures of these compounds were elucidated by Fourier transform ...