Browsing Sivas Cumhuriyet Üniversitesi Sağlık Bilimleri Fakültesi by Author "0000-0002-7132-1325"
Now showing items 1-17 of 17
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A significant association between rs2295190 polymorphism of the ESR1 gene and fibromyalgia syndrome
KAYDOK, Ercan; ÖZMEN, Esma; SARI, İsmail; ŞEN CAKIROĞLU, Gözde; TAŞ, Ayça; SİLİĞ, Yavuz; HAYTA, Emrullah (CMB Association Publiher, 2022)Fibromyalgia syndrome (FMS) is a multifactorial disease characterized by chronic diffuse pain. Genetic factors are also involved in the etiology. However, there is not enough information on the genetic factors that ... -
Anticancer activity, hTERT expression and telomere length analysis in SH-SY5Y neuroblastoma cell lines applied to docetaxel
Inandiklioglu, Nihal; Tas, Ayca; Agbektas, Tugba; Tuncbilek, Zuhal; Raheem, Kayode Yomi; Cinar, Gülcihan; Silig, Yavuz (Elsevier, 05.02.2023)Neuroblastoma is the most common extracranial solid tumor of infancy in a broad range of clinical courses, ranging from spontaneous regression to fatal progression. Telomere maintenance plays an impor- tant role in genome ... -
Biological evaluation and in silico molecular docking studies of Abies cilicica (Antoine & Kotschy) Carrière) resin
Guclu, Gulsen; Tas, Ayca; Dincer, Emine; Ucar, Esra; Kaya, Savas; Berisha, Avni; Dural, Emrah; Silig, Yavuz (Elsevier, 15.09.2023)Abies cilicica (Antoine & Kotschy) Carri`ere) is an endemic species of industrial and medicinal importance. The resin obtained from this plant is effective for different diseases. The chemical content of the ethanol extract ... -
Cytotoxic effect, spectroscopy, DFT, enzyme inhibition, and moleculer docking studies of some novel mesitylaminopropanols: Antidiabetic and anticholinergics and anticancer potentials
Taş, Ayça (Elsevier, 2021)b-Amino alcohols (2–4) used in this study were re-synthesized in accordance with our previous study. All compounds were characterized by the combination of NMR, UV–Vis, IR experimental and theoretical spectral data. Then, ... -
Effect of azomethine group containing compounds on gene profiles in Wnt and MAPK signal patterns in lung cancer cell line: In silico and in vitro analyses
Agbektas, Tugba; Zontul, Cemile; Ozturk, Alpaslan; Huseynzada, Alakbar; Ganbarova, Rana; Hasanova, Ulviyya; Cinar, Gülcihan; Tas, Ayca; Kaya, Savas; Chtita, Samir; Silig, Yavuz (Elsevier, 05.03.2023)The main aims of anticancer drug development studies is to reduce the toxicity of the developed compound and maximize the effectiveness, as well as the discovery of artificial and natural compounds. In recent years, ... -
Effect of azomethine group containing compounds on gene profiles in Wnt and MAPK signal patterns in lung cancer cell line: In silico and in vitro analyses
Agbektas, Tugba; Zontul, Cemile; Ozturk, Alpaslan; Huseynzada, Alakbar; Ganbarova, Rana; Hasanova, Ulviyya; Cinar, Gülcihan; Tas, Ayca; Chtita, Samir; Silig, Yavuz (Elsevier, 05.03.2023)The main aims of anticancer drug development studies is to reduce the toxicity of the developed com- pound and maximize the effectiveness, as well as the discovery of artificial and natural compounds. In recent years, ... -
Experimental and theoretical insights about the effect of some newly designed azomethine group-contained macroheterocycles on oxidative stress and DNA repair gene profiles in neuroblastoma cell lines
Cinar, Gülcihan; Agbektas, Tugba; Huseynzada, Alakbar; Aliyeva, Gunel; Aghayev, Mirjavid; Hasanova, Ulviyya; Kaya, Savas; Chtita, Samir; Nour, Hassan; Tas, Ayca; Silig, Yavuz (Elsevier, 05.09.2023)We report herein the synthesis of new azomethine group containing forty-, sixty-eight- and seventy- two-membered macroheterocyclic compounds and the investigation of their activity against the neurob- lastoma cell line. ... -
Expression levels of BAP1, OGT, and YY1 genes in patients with eyelid tumors
Taş, Ayça; Gümüş, Erkan; Özmen, Esma; Erdoğan, Haydar; Siliğ, Yavuz (De Gruyter, 2021)Objectives: The aim of this study was to investigate BAP1, OGT and YY1 genes and protein levels in 12 samples (8 males, 4 females) of eyelid tumor tissue with basal cell carcinoma (BCC) and 12 normal control subjects ... -
IL‑13 Gene Polymorphisms (‑1112 C/T and ‑1512 A/C) in Patients with Chronic and Aggressive Periodontitis: Effects on GCF and Outcome of Periodontal Therapy
GÖRGÜN PİRİM Emine; TOKER Hülya; TAŞ Ayça; ALPAN Aysan; SARI İsmail; SİLİĞ Yavuz (Medical and Dental Consultants’ Association of Nigeria, 2021)Background: IL‑13 is the key cytokine in the regulation of inflammatory with an autoimmune disease and has an anti‑inflammatory effect. Aims: This study aimed to compare IL‑13 (‑1112 C/T and ‑1512 A/C) gene polymorphisms in ... -
In Silico and In Vitro Studies of Novel Azomethines on DNA Repair Genes in Gastric Cell Lines
Ozturk, Alpaslan; Agbektas, Tugba; Huseynzada, Alakbar; Guliyev, Ruslan; Ganbarova, Rana; Hasanova, Ulviyya; Tas, Ayca; Erkan Sultan; Zontul, Cemile; Inandiklioglu, Nihal; Silig, Yavuz (MDPI, 28.09.2023)We herein report the determination of the cytotoxic activity and expression profiles of some DNA repair genes of newly synthesized azomethines in the gastric cancer cell line (AGS). The studied novel compounds were ... -
In vitro cytotoxic effects, in silico studies, some metabolic enzymes inhibition, and vibrational spectral analysis of novel β-amino alcohol compounds
Tas, Ayca; Tüzün,Burak; Khalilov, Ali N; Taslimi, Parham; Agbektas, Tugba; Keklikcioglu Cakmak, Nese (Elsevier, 05.02.2023)In this study, an efficient single-step method for the preparation of β-amino alcohols ( 1 –3 ) in aqueous media was applied. The aim was to investigate the cytotoxic activity of Compounds 1, 2 and 3 in neu- roblastoma ... -
Investigation of Early Growth Response Protein (EGR) Levels in Patients with Fibromyalgia Syndrome: A Cross-Sectional Study
Tas, Ayca; Agbektas, Tugba; Karadag, Ahmet; Aydin, Süleyman; Hayta, Emrullah; Silig, Yavuz (MDPI, 01.12.2023)Background: Fibromyalgia is a soft tissue rheumatism characterized by chronic and widespread musculoskeletal pain at specific points in the body. Objectives: In this study, we aimed to investigate the relationship between ... -
Leptin/Melanocortin pathway hormones in obese patients after laparoscopic sleeve gastrectomy
Tas, Ayca; Atabey, Mustafa; Gokcen, Pınar; Ozel, M.İlker; Karaca. K, Zuhal; Ugur, Kader; Aydın, Süleyman; Siliğ, Yavuz (VERDUCI PUBLISHERVIA GREGORIO VII, ROME 186-00165, ITALY, 2022)Objective: The melanocortin system is an important neural system underlying the control of body weight and food intake. This system has recently received great attention as a potential target for obesity treatment. Therefore, ... -
Potassium Ion Channel Protein (KCNH) Levels in Patients with Fibromyalgia Syndrome
Taş, Ayça; Hayta, Emrullah; Karadağ, Ahmet; Zontul, Cemile; Özmen, Esma; Aydın, Süleyman; Siliğ, Yavuz (CMB Association Publiher, 2021)Although there is not yet full clarity of the pathogenesis of fibromyalgia syndrome (FM), central sensitization is considered to be responsible. The purpose of this study was to measure the plasma levels of potassium ion ... -
Synthesis of PEGylated nanographene oxide as a nanocarrier for docetaxel drugs and anticancer activity on prostate cancer cell lines
Taş, Ayça; Keklikçioğlu Çakmak, Neşe (SAGE Publishing, 2021)Graphene oxide (GO) has recently been considered one of the most promising carbon derivatives in nanotechnology. It has many excellent features such as tumor targeting ability, biocompatibility and low toxicity. Therefore, ... -
The relationship between serum prolidase activity and histone H3 protein levels and fibromyalgia
Ozturk, Alpaslan; Agbektas, Tugba; Tas, Ayca; Gul, Mehmet Ali; Karadag, Ahmet; Silig, Yavuz (VERDUCI PUBLISHERVIA GREGORIO VII, ROME 186-00165, ITALY, 2022)OBJECTIVE: Fibromyalgia (FM) is a clinical syndrome characterized by prominent physical and psychological impairment and widespread pain on both sides of the body, above and below the waist, and along the axial skeleton. ...