Browsing Meslek Yüksekokulları by Author "49554685-9d54-4666-bf83-86d8fb2f7627"
Now showing items 1-9 of 9
-
1,2,3-Triazole substituted phthalocyanine metal complexes as potential inhibitors for anticholinesterase and antidiabetic enzymes with molecular docking studies
Koçyiğit, Ümit M.; Taslimi, Parham; Tüzün,Burak; Yakan, Hasan; Muğlu, Halit; Güzel, Emre (09.12.2020)In recent years, acetylcholinesterase (AChE) and a-glycosidase (a-gly) inhibition have emerged as a promising and important approach for pharmacological intervention in many diseases such as glaucoma, epilepsy, obesity, ... -
Biological effects and molecular docking studies of Catechin 5-O-gallate: antioxidant, anticholinergics, antiepileptic and antidiabetic potentials
Taslimi, Parham; Kocyigit, Umit M.; Tüzün,Burak; Kirici, Mahinur (Journal of Biomolecular Structure and Dynamics, 04.10.2020)Gallocatechin gallate is a form of catechin and an ester of gallocatechin and gallic acid. This is an epimer of the gallate epigallocatechin. In this study, the effect of this molecule, containing a biologically active ... -
Cytotoxic effect, spectroscopy, DFT, enzyme inhibition, and moleculer docking studies of some novel mesitylaminopropanols: Antidiabetic and anticholinergics and anticancer potentials
Tüzün, Burak; Çakmak, Neşe Keklikçioğlu; Tunçbilek, Zuhal; Taş, Ayhan; Taslimi, Parham; Khalilov, Ali N. (09 October)b-Amino alcohols (2–4) used in this study were re-synthesized in accordance with our previous study. All compounds were characterized by the combination of NMR, UV–Vis, IR experimental and theoretical spectral data. Then, ... -
Design, synthesis, characterization, biological evaluation, and molecular docking studies of novel 1,2-aminopropanthiols substituted derivatives as selective carbonic anhydrase, acetylcholinesterase and a-glycosidase enzymes inhibitors
Huseynova, Afat; Kaya, Ruya; Taslimi, Parham; Farzaliyev, Vagif; Mammadyarova, Xadija; Sujayev, Afsun; Tüzün,Burak; Kocyigit, Umit M.; Alwasel, Saleh; Gülçin, lhami (26.08.2020)In the article, various substituted derivatives of 1,2-aminopropanthiol (1a–g) have been prepared by a general and efficientmethod, in one-steps, starting fromavailable thiirane and aromatic amines (aniline, o-toluidine) ... -
Design, synthesis, characterization, biological evaluation, and molecular docking studies of novel 1,2-aminopropanthiols substituted derivatives as selective carbonic anhydrase, acetylcholinesterase and α-glycosidase enzymes inhibitors
Huseynova, Afat; Kaya, Ruya; Taslimi, Parham; Farzaliyev, Vagif; Mammadyarova, Xadija; Sujayev, Afsun; Tüzün,Burak; Kocyigit, Umit M.; Alwasel, Saleh; Gulçin, İlhami (27.08.2020)In the article, various substituted derivatives of 1,2-aminopropanthiol (1a–g) have been prepared by a general and efficientmethod, in one-steps, starting fromavailable thiirane and aromatic amines (aniline, o-toluidine) ... -
In vitro cytotoxic effects, in silico studies, some metabolic enzymes inhibition, and vibrational spectral analysis of novel β-amino alcohol compounds
Tas, Ayca; Tüzün,Burak; Khalilov, Ali N; Taslimi, Parham; Agbektas, Tugba; Keklikcioglu Cakmak, Nese (Elsevier, 2023/2/5)In this study, an efficient single-step method for the preparation of β-amino alcohols ( 1 –3 ) in aqueous media was applied. The aim was to investigate the cytotoxic activity of Compounds 1, 2 and 3 in neu- roblastoma ... -
In vitro cytotoxic effects, in silico studies, some metabolic enzymes inhibition, and vibrational spectral analysis of novel β-amino alcohol compounds
Tas, Ayca; Tüzün,Burak; Ali, N.; Taslimi, Parham; Agbektas, Tugba; Cakmak, Nese Keklikcioglu (Journal of Molecular Structure, 8 October )In this study, an efficient single-step method for the preparation of β-amino alcohols ( 1 –3 ) in aqueous media was applied. The aim was to investigate the cytotoxic activity of Compounds 1, 2 and 3 in neu- roblastoma ... -
Synthesis and docking calculations of tetrafluoronaphthalene derivatives and their inhibition profiles against some metabolic enzymes
Erdoğan, Musa; Tüzün, Burak; Taslimi, Parham (5 February)Syntheses of tetrahydroepoxy, O‐allylic, O‐prenylic, and O‐propargylic tetrafluoronaphthalene derivatives, starting from 1‐bromo‐2,3,4,5,6‐pentafluorobenzene, are reported here for the first time. The O‐substituted ... -
Synthesis, biological activity and docking calculations of bis-naphthoquinone derivatives from lawsone
Riaz, Muhammad Tariq; Yaqub, Muhammad; Shafiq, Zahid; Ashraf, Abida; Khalid, Muhammad; Taslimi, Parham; Tas, Recep; Tuzun, Burak; Gulçin, İlhami (5 June 202)Some metabolic enzyme inhibitors can be used as Multi-target-Directed-Ligands (MTDL) in Medicinal chemistry therefore, synthesis and determination of alternative inhibitors are essential. In this study, novel bisnapthoquinone ...