dc.contributor.author | Gezegen, Hayreddin | |
dc.contributor.author | Tutar, Uğur | |
dc.contributor.author | Hepokur, Ceylan | |
dc.contributor.author | Tüzün, Gamze | |
dc.contributor.author | Atioğlu, Zeliha | |
dc.contributor.author | Akkurt, Mehmet | |
dc.date.accessioned | 2022-05-13T08:37:48Z | |
dc.date.available | 2022-05-13T08:37:48Z | |
dc.date.issued | 2021 | tr |
dc.identifier.citation | Title: Michael/Michael Addition Cascade of 2-Benzylidene-1-indanones with Chalcones: Synthesis and Biological Evaluations of Novel Polycyclic Compounds
Author(s): Gezegen, H (Gezegen, Hayreddin); Tutar, U (Tutar, Ugur); Hepokur, C (Hepokur, Ceylan); Tuzun, G (Tuzun, Gamze); Atioglu, Z (Atioglu, Zeliha); Akkurt, M (Akkurt, Mehmet)
Source: CHEMISTRYSELECT Volume: 6 Issue: 36 Pages: 9625-9631 DOI: 10.1002/slct.202102738 Published: SEP 27 2021
Abstract: A series of novel racemic 2-aryloyl-1,3-diaryl-2,3,3a,8a-tetrahydrocyclopenta[a]inden-8(1H)-one derivatives were synthesized from KOtBu mediated Michael/Michael addition reaction of 2-benzylidene-1-indanones with chalcones in high yields. This method provides an efficient route for the synthesis of a new class of polycyclic compounds have five stereo centers. The obtained polycyclic compounds were evaluated for the antimicrobial and anticancer activities against fifteen microorganism and three cell lines. The compound 3 r have the best activity value against the cells (MCF-7 IC50=18.01 +/- 0.39 mu g/mL) (MDA-MB- 231 IC50=18.78 +/- 1.75 mu g/mL) (MCF-10 A IC50=31.31 +/- 0.05 mu g/mL). | tr |
dc.identifier.uri | https://hdl.handle.net/20.500.12418/13002 | |
dc.description.abstract | A series of novel racemic 2-aryloyl-1,3-diaryl-2,3,3a,8a-tetrahydrocyclopenta[a]inden-8(1H)-one derivatives were synthesized from KOtBu mediated Michael/Michael addition reaction of 2-benzylidene-1-indanones with chalcones in high yields. This method provides an efficient route for the synthesis of a new class of polycyclic compounds have five stereo centers. The obtained polycyclic compounds were evaluated for the antimicrobial and anticancer activities against fifteen microorganism and three cell lines. The compound 3 r have the best activity value against the cells (MCF-7 IC50=18.01 +/- 0.39 mu g/mL) (MDA-MB- 231 IC50=18.78 +/- 1.75 mu g/mL) (MCF-10 A IC50=31.31 +/- 0.05 mu g/mL). | tr |
dc.description.sponsorship | TUBİTAK – 116Z480 | tr |
dc.language.iso | eng | tr |
dc.relation.isversionof | 10.1002/slct.202102738 | tr |
dc.rights | info:eu-repo/semantics/openAccess | tr |
dc.title | Michael/Michael Addition Cascade of 2-Benzylidene-1- indanones with Chalcones: Synthesis and Biological Evaluations of Novel Polycyclic Compounds | tr |
dc.type | article | tr |
dc.contributor.department | Sağlık Bilimleri Fakültesi | tr |
dc.contributor.authorID | https://orcid.org/0000-0003-3602-7400 | tr |
dc.identifier.volume | 6 | tr |
dc.identifier.issue | 36 | tr |
dc.identifier.endpage | 9631 | tr |
dc.identifier.startpage | 9625 | tr |
dc.relation.tubitak | 116Z480 | |
dc.relation.publicationcategory | Uluslararası Hakemli Dergide Makale - Kurum Öğretim Elemanı | tr |