dc.contributor.author | GÖRGÜN PİRİM Emine | |
dc.contributor.author | TOKER Hülya | |
dc.contributor.author | TAŞ Ayça | |
dc.contributor.author | ALPAN Aysan | |
dc.contributor.author | SARI İsmail | |
dc.contributor.author | SİLİĞ Yavuz | |
dc.date.accessioned | 2022-05-13T10:11:45Z | |
dc.date.available | 2022-05-13T10:11:45Z | |
dc.date.issued | 2021 | tr |
dc.identifier.uri | https://hdl.handle.net/20.500.12418/13010 | |
dc.description.abstract | Background: IL‑13 is the key cytokine in the regulation of inflammatory with
an autoimmune disease and has an anti‑inflammatory effect. Aims: This study
aimed to compare IL‑13 (‑1112 C/T and ‑1512 A/C) gene polymorphisms
in patients with aggressive periodontitis (AgP), chronic periodontitis (CP),
and periodontally healthy group (C) and evaluate the effect of nonsurgical
periodontal therapy on gingival crevicular fluid (GCF) IL‑13 levels in patients.
Materials and Methods: One hundred thirty patients with AgP, 120 patients with
CP, and 70 periodontally healthy subjects were included in this study. Clinical
parameters were recorded (plaque and gingival index, probing pocket depth, clinical
attachment level), and GCF and blood samples were taken at baseline and 6‑week.
Nonsurgical periodontal therapy was performed in patients with periodontitis.
Gene analyses (IL‑13 − 1112C/T (rs1800925) and − 1512 A/C (rs1881457)
were performed with real‑time polymerase chain reaction (PCR) and cytokine
levels were determined by an enzyme‑linked immunosorbent assay method.
Results: AgP and CP patients showed significant improvement in clinical
parameters after periodontal therapy (P < 0.05). According to results, genotype
distributions and allele frequencies in IL‑13 variants − 1112C/T and − 1512 A/C
were found similarly in all groups (P > 0.05). In the AgP group, GCF IL‑13
cytokine level is statistically significant and increased in 6 weeks; however, in
the CP group, there is no statistically significant difference between baseline and
6 week. In the AgP group, baseline GCF IL‑13 cytokine level is lower than those
of the CP group and C group (P < 0.05). Conclusion: Within the limits of this
study, IL‑13 ‑1112 and ‑1512 gene polymorphisms have not been associated with
AgP and CP, and GCF IL‑13 cytokine level is increased after treatment in the AgP
group. | tr |
dc.language.iso | eng | tr |
dc.publisher | Medical and Dental Consultants’ Association of Nigeria | tr |
dc.relation.isversionof | 10.4103/njcp.njcp_487_19 | tr |
dc.rights | info:eu-repo/semantics/openAccess | tr |
dc.subject | Aggressive periodontitis, gene polymorphism, IL‑13, periodontal therapy | tr |
dc.title | IL‑13 Gene Polymorphisms (‑1112 C/T and ‑1512 A/C) in Patients with Chronic and Aggressive Periodontitis: Effects on GCF and Outcome of Periodontal Therapy | tr |
dc.type | article | tr |
dc.relation.journal | Nigerian Journal of Clinical Practice | tr |
dc.contributor.department | Sağlık Bilimleri Fakültesi | tr |
dc.contributor.authorID | 0000-0002-7132-1325 | tr |
dc.identifier.volume | 24 | tr |
dc.identifier.issue | 7 | tr |
dc.identifier.endpage | 972 | tr |
dc.identifier.startpage | 965 | tr |
dc.relation.publicationcategory | Uluslararası Hakemli Dergide Makale - Kurum Öğretim Elemanı | tr |