dc.identifier.citation | Mehmet Abdullah Alagöz1,Arzu Karakurt1,Ceylan Hepokur2,Emine Şalva3,Tijen Önkol4,Muhammed M. Ghoneim5,Mohamed A. Abdelgawad6ORSİD,Ahmet Hames7ORSİD,Hoon Kim8,*ORSİDvebijo Mathew9,*
1İnönü Üniversitesi Eczacılık Fakültesi Farmasötik Kimya Anabilim Dalı, Malatya 44280, Türkiye
2Eczacılık Fakültesi, Temel Eczacılık Bilimleri Anabilim Dalı, Sivas Cumhuriyet Üniversitesi, Sivas 58100, Türkiye
3İnönü Üniversitesi Eczacılık Fakültesi Farmasötik Biyoteknoloji Anabilim Dalı, Malatya 44280, Türkiye
4Eczacılık Bölümü, Eczacılık Fakültesi, Gazi Üniversitesi, Ankara 06100, Türkiye
5Eczacılık Uygulamaları Anabilim Dalı, Eczacılık Fakültesi, AlMaarefa Üniversitesi, Ad Diriyah 13713, Suudi Arabistan
6Farmasötik Kimya Bölümü, Eczacılık Fakültesi, Jouf Üniversitesi, Sakaka 72341, Suudi Arabistan
7Eczacılık ve Endüstriyel Eczacılık Bölümü, Eczacılık Fakültesi, Taif Üniversitesi, PO Box 11099, Taif 21944, Suudi Arabistan
8Eczacılık Bölümü ve Yaşam Farmasötik Bilimleri Araştırma Enstitüsü, Sunchon Ulusal Üniversitesi, Suncheon 57922, Kore
9Farmasötik Kimya Bölümü, Amrita Eczacılık Okulu, Amrita Vishwa Vidyapeetham, AIMS Sağlık Bilimleri Kampüsü, Kochi 682 041, Hindistan | tr |
dc.description.abstract | : In this study, 12 new 1-aryl-2-(3,5-dimethylpyrazol-1-yl)ethanone oxime ether derivatives
were designed and synthesized to investigate their cytotoxic effects. The in vitro cytotoxic activities
of the compounds were evaluated against cervix, colon, breast, glioma, neuroblastoma, and lung
cancer cell lines, as well as a healthy cell line using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazo lium bromide (MTT) assays with 5-fluorouracil (5-FU) as the reference compound. Compound 5f
(IC50 = 5.13 µM) was found to be more effective than 5-FU (IC50 = 8.34 µM) in the C6 cancer cell line,
and it had no cytotoxic effect on the L929 healthy cell line. Flow cytometry was used to investigate
the mechanism of action of compound 5f on the cell cycle of the C6 cell line. The analysis showed
that cell death was significantly due to apoptosis. These results indicate that compound 5f induces
cell cycle arrest, and may be effective in treating glioma. | tr |