Metabolomics in Biomarker Identification for Cardiovascular Diseases, Metabolomics and Clinical Approach
Date
2023Metadata
Show full item recordAbstract
Metabolomics is the systematic analysis of the particular chemical
fingerprints of small molecules or metabolite profiles which are
associated with a different cellular metabolic process in a cell, organ, or
organism. Events in a cell are not described completely by messenger
RNA gene expression data and proteomic analyses, but metabolic
profiling supplies direct and indirect physiological insights, which can
possibly be measurable in a broad range of biospecimens. Even though
not specific to cardiac conditions, identification, confirmation, clinical
validation, and bedside tests are a biomarker exploration path to translate
metabolomics into cardiovascular biomarkers. Technological progress in
metabolomic tools (such as nuclear magnetic resonance spectroscopy and
mass spectrometry) and more complicated bioinformatics and analytical
techniques help to evaluate low- molecular-weight metabolites in
biospecimens and ultimately supply a unique insight into determined and
novel metabolic pathways. Systematic metabolomics can provide
physiological knowledge of cardiovascular disease states in addition to
traditional profiling and can include the definition of metabolic reactions
of an individual or population to therapeutic interventions or
environmental exposures.