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A Prospective Case-Control Study Analyzes 12 Thrombophilic Gene Mutations in Turkish Couples with Recurrent Pregnancy Loss
(WILEY, 2010)
Problem Recurrent pregnancy loss (RPL) is a heterogeneous disorder. The contribution of specific thrombophilic genes to the pathophysiology of RPL has remained controversial. We evaluated the prevalences of 12 thrombophilic ...
The Presence of PAI-1 4G/5G and ACE DD Genotypes Increases the Risk of Early-Stage AVF Thrombosis in Hemodialysis Patients
(TAYLOR & FRANCIS LTD, 2011)
Background: In this study, we investigated the relationship between early arteriovenous fistula (AVF) thrombosis with angiotensin-converting enzyme (ACE) gene and thrombophilic factor gene polymorphisms. Methods: Thirty-five ...
SRY and AZF gene variation in male infertility: a cytogenetic and molecular approach
(SPRINGER, 2007)
Aim The aim of this study was to identify the genetic effects of Y chromosome and azoospermia factor (AZF) gene variation in men with infertility and to elucidate the molecular mechanism responsible for the identified point ...
eNOS G894T Polymorphism and Abdominal Aortic Aneurysms
(SAGE PUBLICATIONS INC, 2010)
Background: The genetic risk factors that contribute to the risk of developing abdominal aortic aneurysm ( AAA) are poorly understood. We assessed the association of endothelial nitric oxide synthase ( eNOS) gene polymorphism ...
Predictive significance of KRAS point mutation in patients with non-small cell lung carcinoma relation to smoking and asbestos exposure in middle Anatolia population
(DRUNPP-SARAJEVO, 2010)
Persons who have been occupationally exposed to environmental mutagens have a substantially increased risk for somatic oncogene mutations. Structural mutation in viral kristen rat sarcoma oncogene homolog 2 (KRAS; v-Ki-ras ...
Association of endothelial nitric oxide synthase Glu298Asp gene polymorphism in psoriasis cases with hypertension
(K FAISAL SPEC HOSP RES CENTRE, 2014)
BACKGROUND AND OBJECTIVES: Psoriasis is a common autoimmune-mediated chronic, inflammatory skin disease. Although, the molecular mechanism is not completely understood, psoriasis is caused by genetic and non-genetic ...
Aldosterone Synthase CYP11B2 Gene Promoter Polymorphism in a Turkish Population With Chronic Kidney Disease
(IRANIAN SOC NEPHROLGY, 2015)
Introduction. It has been shown that gene polymorphisms influence the development and progression of chronic kidney disease (CKD). Many studies have indicated that aldosterone synthase CYP11B2 gene polymorphism (-344C>T) ...
Association Between ABCB1 (MDR1) Gene Polymorphism and Unresponsiveness Combined Therapy in Chronic Hepatitis C virus
(KOWSAR PUBL, 2013)
Background: To treat viral infection of chronic hepatitis C (CHC) is a main strategy to prevent progression of liver disease, and cancer. Some patients with CHC have failed to respond to the common antiviral therapy in ...
In vivo evaluation of the genotoxic effects of clomiphene citrate on rat reticulocytes: A micronucleus genotoxicity
(KARGER, 2006)
Objective: To determine the genotoxic effects of clomiphene citrate (CC) on rat reticulocytes in vivo. Methods: In this prospective, randomized, controlled study, rats were each assigned randomly to the CC 50, CC 100, CC ...
Methylenetetrahydrofolate Reductase Gene Germ-Line C677T and A1298C SNPs are Associated with Colorectal Cancer Risk in the Turkish Population
(ASIAN PACIFIC ORGANIZATION CANCER PREVENTION, 2014)
Colorectal cancer (CRC) is the third most common cause of death due to cancer in the worldwide and the incidence is also increasing in Turkey. Our present aim was to investigate any association between germ-line ...