Browsing Temel Eczacılık Bilimleri Bölümü by Issue Date
Now showing items 1-20 of 114
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Synthesis, and docking studies of novel tetrazole S-alkyl derivatives as antimicrobial agents
(Taylor & Francis, 01.09.2022)A series of novel tetrazole-S-alkyl-piperazine derivatives were synthesized and evaluated for their antifungal activity against C. albicans (ATCC 24433), C. krusei (ATCC 6258) and C. parapsilosis (ATCC 22019) and ... -
Decoration, Characterization and Antimicrobial Activity Evaluation of Novel Nano-Based 1,2-Phenylenediamine Functionalized Maleic Anhydride-Allylphenyl Ether Conjugate
(Chemistry Europe, 02 October)1,2-Phenylenediamine (o-PDA) is a well-known fluorescent dye that enables the decoration of next generation chemotherapeutics. A novel o-PDA-functionalized maleic anhydride-allyl phenyl ether (poly(MA-alt-APE)/o-PDA ... -
Sensitive determination of Fluoxetine and Citalopram antidepressants in urine and wastewater samples by liquid chromatography coupled with photodiode array detector
(02.05.2021)A new analyte separation and preconcentration method for the trace determination of antidepressant drugs, Fluoxetine (FLU) and Citalopram (CIT) in urine and wastewaters, was developed based on HPLC-DAD analysis after ... -
Design, synthesis and biological evaluation of novel ketone derivatives containing benzimidazole and 1,3,4-triazole as CA inhibitors
(03.10.2023)In this study, we synthesized a series of new benzimidazole-triazole (6a-6k) derivatives and characterized them by 1 H NMR, 13C NMR, and HRMS. These compounds were evaluated for their inhibitory activity against hCA-I and ... -
The synthesis and characterization of iron nanoparticles with lemon peel and its use in magnetic solid phase extraction for trace levels of lead (II)
(Springer, 03/03/2022)In this study, a new magnetic solid phase extraction method (MSPE) was developed for the enrichment and separation of trace amount Pb(II) on the magnetic nanoparticles synthesized using lemon peel ( Fe3O4-LP). The ... -
Synthesis, biological evaluation and in silico studies of novel thiadiazole-hydrazone derivatives for carbonic anhydrase inhibitory and anticancer activities
(04.08.2023)ABSTRACT Thiadiazole and hydrazone derivatives (5a–5i) were synthesized and their chemical structures were verified and described by 1 H NMR, 13 C NMR, and HRMS spectra. Three cancer cell lines (MCF-7, MDA, and ... -
Determination of phenolic compounds in human saliva after oral administration of red wine by high performance liquid chromatography
(Elsevier, 05.02.2022)Search ScienceDirect Outline Highlights Abstract Keywords 1. Introduction 2. Materials and methods 3. Results and discussion 4. Conclusions Declaration of Competing Interest Acknowledgments Appendix A. Supplementary ... -
New imidazole derivatives as aromatase inhibitor: Design, synthesis, biological activity, molecular docking, and computational ADME-Tox studies
(06.01.2023)In this study, a series of imidazole derivatives was designed, synthesized, and evaluated for in vitro bi- ological activity on the human breast cancer cell line MCF7 by MTT assay. To determine the selectivity of the ... -
Determination of Sulfadiazine in Natural Waters by Pine Needle Biochar – Derivatized Magnetic Nanocomposite Based Solid-Phase Extraction (SPE) with High-Performance Liquid Chromatography (HPLC)
(06.04.2022)A magnetic solid-phase extraction (MSPE) method was developed forthe facile and sensitive determination of sulfadiazine prior to high-performance liquid chromatography (HPLC) analysis. The magneticsorbent was prepared by ... -
Synthesis, and docking studies of novel tetrazole-S-alkyl derivatives as antimicrobial agents
(07.01.2023)A series of novel tetrazole-S-alkyl-piperazine derivatives were synthesized and evaluated for their antifungal activity against C. albicans (ATCC 24433), C. krusei (ATCC 6258) and C. parapsilosis (ATCC 22019) and ... -
INVESTIGATION OF THE ANTIPROLIFERATIVE EFFECT OF SALVIA CADMICA ON COLON CANCER
(07.05.2023)Salvia cadmica is an endemic species known to have antioxidant, antimicrobial and aromatic properties and the existence of Salvia species is known to date back to 753 BC. This species, whose medicinal properties were ... -
Determination of chloramphenicol and tetracycline residues in milk samples by means of nanofiber coated magnetic particles prior to high-performance liquid chromatography-diode array detection
(Elsevier, 08.03.2021)A magnetic solid phase extraction (MSPE) coupled with high-performance liquid chromatography-diode array detection (HPLC-DAD) methodology was developed for the determination of chloramphenicol (CP) and tetracycline (TET) ... -
Design, synthesis and molecular docking studies of novel benzimidazole-1,3,4-oxadiazole hybrids for their carbonic anhydrase inhibitory and antioxidant effects
(Medicinal Chemistry Research, 08.08.2022)In this study, eleven new compounds with a series of benzimidazole-1,3,4-oxadiazole derivatives structures were synthesized and evaluated for their human (h) carbonic anhydrase inhibitory activities against two isoforms ... -
Synthesis, Molecular Docking, Dynamics, Quantum-Chemical Computation, and Antimicrobial Activity Studies of Some New Benzimidazole−Thiadiazole Hybrids
(ACS, 09.11.2022)In this study, some new compounds, which are 2aminothiadiazole derivatives linked by a phenyl bridge to the 2position of the benzimidazole ring, were designed and synthesized as antimicrobial agents. The structures of ... -
Interaction of water soluble cationic gallium (III) phthalocyanines with different G-quadruplex DNAs
(Elsevier, 1 November)Small molecule-G-quadruplex DNA interaction has been gained considerable interest due to existence of G-quadruplex structures in telomeres and promotor regions of proto-oncogenes. In the present study, the interaction of ... -
Development of quantum dot-phthalocyanine integrated G-quadruplex/double-stranded DNA biosensor
(1 October )n the present study, the phthalocyanine (Pc) integrated mercaptopropionic acid capped quantum dot (mpa@QD) biosensor has been developed for the quantitative determination of G-quadruplex and double-stranded DNA. The working ... -
Application of a new dithizone grafted polymeric adsorbent for solid phase microextraction of manganese and copper prior to FAAS in fortified vegetables and barbecue samples
(13.06.2022)A new potential solid phase material called as dithizone@PAA was synthesized for first times, characterized and utilized as an easy versatile polymeric sorbent for the shake-assisted dispersive solid-phase micro-extraction ... -
Deep Eutectic Solvent-based Extraction of As, Mn, Pb, Cr, and Ni from Spleen, Kidney, and Brain Samples
(14 Septemb)Deep eutectic solvent extraction for As, Mn, Pb, Cr, and Ni from spleen, kidney, and brain samples was investigated. The experimental parameters such as type and amount of deep eutectic solvent and sample/deep eutectic ... -
Benzimidazole-hydrazone derivatives: Synthesis, in vitro anticancer, antimicrobial, antioxidant activities, in silico DFT and ADMET studies
(Elsevier, 14.08.2022)Based on the biologically active heterocycle compounds, a series of new benzimidazole-hydrazone deriva- tives ( 3a-3j ) were synthesized, starting from 4-(6-chloro-1 H -benzimidazol-2-yl) benzohydrazide. The syn- thesized ... -
Novel Applications of Microextraction Techniques Focused on Biological and Forensic Analyses
(MDPI, 15.02.2022)In recent years, major attention has been focused on microextraction procedures that allow high recovery of target analytes, regardless of the complexity of the sample matrices. The most used techniques included liquid-liquid ...