Temel Eczacılık Bilimleri Bölümü: Recent submissions
Now showing items 41-60 of 114
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Cytotoxic, Antioxidant, Antibiofilm, and Antimicrobial Activities of Mushroom Species from Turkey
(HAZİRAN 20)ABSTRACT: Mushrooms, which have been collected to meet the nutritional needs of the world for many years, have gained medical importance thanks to the bioactive compounds they produce. Thanks to studies carried out to ... -
Benzimidazol-2-ylidene Silver Complexes: Synthesis, Characterization, Antimicrobial and Antibiofilm Activities, Molecular Docking and Theoretical Investigations
(EYLÜL 2023)Abstract: Five silver(I) complexes, namely chloro[1-methallyl-3-benzyl)benzimidazol-2-ylidene] silver (6), chloro[1-methallyl-3-(2,3,5,6-tetramethylbenzyl)benzimidazol-2-ylidene]silver (7), chloro[1- methallyl-3-(3,4,5 ... -
Synthesis of Bis-Nicotinonitrile Derivatives and Investigations of Antimicrobial and Antibiofilm Activities
(Ekim 2023)In this study aimed to the synthesis of novel bis-nicotinonitrile derivatives starting from 1,3-bis-chalcones and investigate their antimicrobial activity potentials. Bis-nicotinonitrile derivatives were synthesized from ... -
Decoration, Characterization and Antimicrobial Activity Evaluation of Novel Nano-Based 1,2-Phenylenediamine Functionalized Maleic Anhydride-Allylphenyl Ether Conjugate
(Chemistry Europe, 02 October)1,2-Phenylenediamine (o-PDA) is a well-known fluorescent dye that enables the decoration of next generation chemotherapeutics. A novel o-PDA-functionalized maleic anhydride-allyl phenyl ether (poly(MA-alt-APE)/o-PDA ... -
Pyrazolyl‐Benzoxazinone Derivatives as Dual Hsp Inhibitors in Human Breast Cancer
(2022)Heat Shock Proteins (Hsps) play major role on the onset of several cancers. Metabolic rates of cancer cells are higher compared to that of untransformed cells. This accelerated rate force functional substrate proteins to ... -
Possible effects of clinoptilolite on small intestinal ischemia-reperfusion injury caused by experimental mesenteric artery occlusion
(2022)Objectives: Mesenteric ischemia is a surgical emergency caused by poor blood supply to the intestines. In ischemia,the decrease in blood flow to the tissue causes acidosis and cell death through anaerobic metabolism. ... -
The role of cytokeratin 19 levels in the determination of endometriosis stages
(2022)Objective/Aim: Endometrisosis, one of the most common gynecological disease, is characterized by the presence of endometriotic tissue outside of uterine cavity. The development and the validation of a simple blood ... -
A new method for synthesis of carbon nanoparticle and its applications
(2022)In the present study, we synthesized carbon nanoparticles with a different method using chi tosan, a natural polymer. As a result, carbon nanomaterials were diffused directly through the intestinal membrane, and carbon ... -
Investigation of possible associations between tryptophan/kynurenine status and FOXP3 expression in colorectal cancer
(2022)Tryptophan metabolism in the tumor microenvironment exerts immunosuppressive effects by affecting the anti-tumor functions of immune cells. The immunosuppressive roles of tryptophan and tryptophan metabolites and their ... -
Design, synthesis and in vitro antiproliferation activity of some 2-aryl and -heteroaryl benzoxazole derivatives
(2022)Background: Phortress produces reactive electrophilic metabolites that form DNA adducts only in sensitive tumor cells. The authors converted the 2-phenylbenzothiazole nucleus in phortress to 2- aryl and -heteroaryl ... -
Synthesis, Biological Evaluation and In Silico Studies of Some 2‐Substituted Benzoxazole Derivatives as Potential Anticancer Agents to Breast Cancer
(2022)In an attempt to develop potent and selective anticancer agents, some 5- or 6- and N-substituted benzoxazol-2-carbox amide derivatives were designed, synthesized, and evaluated for their cyclooxygenase inhibitory, antioxidant, ... -
Evaluation of the effects of newly synthesized metallophthalocyanines on breast cancer cell lines with photodynamic therapy
(2022)In this study, the new phthalonitrile derivative 3-(4-(3-oxobutyl)phenoxy)phthalonitrile (1) and its non peripheral metallophthalocyanine derivatives [zinc (2), copper (3), cobalt (4), manganese (5), gallium (6), and ... -
circRNAs in drug resistance of breast cancer
(2022)Abstract: Breast cancer (BC) is the most common heterogeneous disease in women and one of the leading causes of cancer-related death. Surgery, chemotherapy, radiotherapy, hormone, and targeted therapy are the gold standards ... -
Investigation of Interaction of Bismarck Brown Y-Palladium Complex with AS1411 G-quadruplex Aptamer
(29.12.2022)Increased metabolic activity and metastasis are the main and most known characteristics of cancer cells. Increased activity of the cells results in an increase in the transcription, translation, and replication rate of ... -
EXTRACTION AND DETERMINATION OF Cd, Co, Se, V AND Ag LEVELS IN COW’S MUSCLE, LIVER, KIDNEY, LUNG, SPLEEN AND BRAIN SAMPLES
(2022/4/1)A deep eutectic solvent (DES) consisting of oxalic acid and choline chloride was prepared and used to extract Cd, Co, Se, V, and Ag from meats. The metal levels were determined in muscle, liver, kidney, lung, spleen, ... -
Deep Eutectic Solvent-based Extraction of As, Mn, Pb, Cr, and Ni from Spleen, Kidney, and Brain Samples
(14 Septemb)Deep eutectic solvent extraction for As, Mn, Pb, Cr, and Ni from spleen, kidney, and brain samples was investigated. The experimental parameters such as type and amount of deep eutectic solvent and sample/deep eutectic ... -
One-pot modification of oleate-capped UCNPs with AS1411 G-quadruplex DNA in a fully aqueous medium
(5 June 202)In the present work, modification of oleate-capped upconverting nanoparticles (OA@UCNPs) with AS1411 G-quadruplex DNA by a one-pot aqueous strategy was presented. The G-quadruplex structure of AS1411 and structural alterations ... -
A porous fabric-based molecularly imprinted polymer for specific recognition of tetracycline by radiation-induced RAFT-mediated graft copolymerization
(October 20)Despite technical and methodological advances, the selective separation of antibiotics from aqueous media remains a challenge. In this work, a novel molecularly imprinting polymer (MIP) with specific recognition sites was ... -
Development of quantum dot-phthalocyanine integrated G-quadruplex/double-stranded DNA biosensor
(1 October )n the present study, the phthalocyanine (Pc) integrated mercaptopropionic acid capped quantum dot (mpa@QD) biosensor has been developed for the quantitative determination of G-quadruplex and double-stranded DNA. The working ... -
Determination of Sulfadiazine in Natural Waters by Pine Needle Biochar – Derivatized Magnetic Nanocomposite Based Solid-Phase Extraction (SPE) with High-Performance Liquid Chromatography (HPLC)
(06.04.2022)A magnetic solid-phase extraction (MSPE) method was developed forthe facile and sensitive determination of sulfadiazine prior to high-performance liquid chromatography (HPLC) analysis. The magneticsorbent was prepared by ...