Browsing Temel Eczacılık Bilimleri Bölümü Makale Koleksiyonu by Author "Eczacılık Fakültesi"
Now showing items 21-40 of 88
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Decolourization of Methylene Blue in Aqueous Solution by Photocatalytic Oxidation, Fenton Oxidation and Biosorption
Kartal Temel, Nuket; Bağda, Esra (Cumhuriyet Science Journal, 27.12.2022)The aim of the study was to investigate decolourization of Methylene Blue (MB) in aqueous solution using advanced oxidation processes (AOPs) and biosorption comparatively. Photocatalytic decolourization of MB was studied ... -
Decoration, Characterization and Antimicrobial Activity Evaluation of Novel Nano-Based 1,2-Phenylenediamine Functionalized Maleic Anhydride-Allylphenyl Ether Conjugate
Karakus Gülderen; Atas Mehmet (Chemistry Europe, 02 October)1,2-Phenylenediamine (o-PDA) is a well-known fluorescent dye that enables the decoration of next generation chemotherapeutics. A novel o-PDA-functionalized maleic anhydride-allyl phenyl ether (poly(MA-alt-APE)/o-PDA ... -
Design, synthesis and biological evaluation of novel bischalcone derivatives as potential anticancer agents
Burmalıoğlu Serdar; Göbek, Arzu; Özturk Aydın,Busra; Yurtoğlu, Emine; Nur Aydın,Busra; Yalcin Ozkat,Gozde; Hepokur, Ceylan; Şimşek Özek, Nihal; Ayşin, Ferhunde; Altundas, Ramazan; Algul,Oztekin (1April 202)Building on our previous work that discovered chalcone as a promising pharmacophore for anticancer activity, we have various other chalcone derivatives and have synthesized a series of novel bischalcone to explore their ... -
Design, synthesis and biological evaluation of novel ketone derivatives containing benzimidazole and 1,3,4-triazole as CA inhibitors
ACAR ÇEVİK ULVİYE; Işık Ayşen; Kapavarapu Ravikumar; KÜÇÜKOĞLU KAAN; NADAROĞLU HAYRUNNİSA; BOSTANCI HAYRANİ EREN; ÖZKAY YUSUF; KAPLANCIKLI ZAFER ASIM (03.10.2023)In this study, we synthesized a series of new benzimidazole-triazole (6a-6k) derivatives and characterized them by 1 H NMR, 13C NMR, and HRMS. These compounds were evaluated for their inhibitory activity against hCA-I and ... -
Design, synthesis and in vitro antiproliferation activity of some 2-aryl and -heteroaryl benzoxazole derivatives
Background: Phortress produces reactive electrophilic metabolites that form DNA adducts only in sensitive tumor cells. The authors converted the 2-phenylbenzothiazole nucleus in phortress to 2- aryl and -heteroaryl ... -
Design, synthesis and molecular docking studies of novel benzimidazole-1,3,4-oxadiazole hybrids for their carbonic anhydrase inhibitory and antioxidant effects
Küçükoğlu, Kaan; Çevik, Ulviye Acar; Nadaroğlu, Hayrunnisa; Çelik, İsmail; Işık, Ayşen; Bostancı, Hayrani Eren; Özkay, Yusuf; Kaplancıklı, Zafer Asım (Medicinal Chemistry Research, 08.08.2022)In this study, eleven new compounds with a series of benzimidazole-1,3,4-oxadiazole derivatives structures were synthesized and evaluated for their human (h) carbonic anhydrase inhibitory activities against two isoforms ... -
Determination of biological studies and molecular docking calculations of isatin-thiosemicarbazone hybrid compounds
Koçyiğit,Ümit M.; Doğan, Murat; Muğlu, Halit; Taslimi, Parham; Tüzün,Burak; Yakan,Hasan; Bal, Halil; Güzel,Emre; Gülçin,İlhami (Elsevier, 2022/09/15)Design, synthesis, structural elucidation, and investigation of cytotoxic and antimicrobial activity, butyrylcholinesterase (BChE), and acetylcholinesterase (AChE) enzyme inhibition effects of isatinthiosemicarbazone ... -
Determination of chloramphenicol and tetracycline residues in milk samples by means of nanofiber coated magnetic particles prior to high-performance liquid chromatography-diode array detection
Vuran, Büşra; Ulusoy, Halil İbrahim; Sarp,Gökhan; Ulusoy, Songül; Morgül, Ümmügülsüm; Kabir,Abuzar; Tartaglia, Angela; Locatelli, Marcello; Soylak, Mustafa (Elsevier, 08.03.2021)A magnetic solid phase extraction (MSPE) coupled with high-performance liquid chromatography-diode array detection (HPLC-DAD) methodology was developed for the determination of chloramphenicol (CP) and tetracycline (TET) ... -
Determination of phenolic compounds in human saliva after oral administration of red wine by high performance liquid chromatography
Tartaglia, Angela; Romasco, T; D’Ovidio, Cristian; Rosato, Enrica; Ulusoy, Halil İbrahim; Furton.G, Kenneth; Kabir,Abuzar; Locatelli, Marcello (Elsevier, 05.02.2022)Search ScienceDirect Outline Highlights Abstract Keywords 1. Introduction 2. Materials and methods 3. Results and discussion 4. Conclusions Declaration of Competing Interest Acknowledgments Appendix A. Supplementary ... -
Determination of Sulfadiazine in Natural Waters by Pine Needle Biochar - Derivatized Magnetic Nanocomposite Based Solid-Phase Extraction (SPE) with High-Performance Liquid Chromatography (HPLC)
Remziye Nur Avcı, Tülay Oymak, Esra Bagda (Taylor&Francis, 26/03/2022)A magnetic solid-phase extraction (MSPE) method was developed for the facile and sensitive determination of sulfadiazine prior to high-performance liquid chromatography (HPLC) analysis. The magnetic sorbent was prepared ... -
Determination of sunset yellow, allura red, and fast green using a novel magnetic nanoadsorbent modified with Elaeagnus angustifolia based on magnetic solid-phase extraction by HPLC
Tülay Oymak, Emrah Dural (UNIV SAO PAULO, CONJUNTO QUIMICAS, 2022)Sunset yellow (SY), allura red (AR) and fast green (FG) are frequently used in commercial food products, although they are considered to be hazardous to public health due to their toxic efficacy and high exposure risk ... -
Development of quantum dot-phthalocyanine integrated G-quadruplex /double-stranded DNA biosensor
Topcu, Ayşe; Bağda, Esra; Oymak, Tülay; Durmuş, Mahmut (Elsevier, 2022)In the present study, the phthalocyanine (Pc) integrated mercaptopropionic acid capped quantum dot (mpa@QD) biosensor has been developed for the quantitative determination of G-quadruplex and doublestranded DNA. The ... -
Development of quantum dot-phthalocyanine integrated G-quadruplex/double-stranded DNA biosensor
Topcu, Ayşe; Bağda, Esra; Oymak, Tülay; Durmuş, Mahmut (1 October )n the present study, the phthalocyanine (Pc) integrated mercaptopropionic acid capped quantum dot (mpa@QD) biosensor has been developed for the quantitative determination of G-quadruplex and double-stranded DNA. The working ... -
Emerging Trends in Pharmacotoxicological and Forensic Sample Treatment Procedures
Valentina Greco; Alessandro Giuffrida; Marcello Locatelli; Fabio Savini; Ugo de Grazia; Luigi Ciriolo; Miryam Perrucci; Abuzar Kabir; Halil Ibrahim Ulusoy; Cristian D’Ovidio; and Imran Ali (MDPI, 22 Februar)One of the most discussed topics concerns the sample preparation before the analysis and, therefore, all the operations necessary to eliminate the interferents, clean up the specimens, and extract the analytes of interest, ... -
Evaluation of the effects of newly synthesized metallophthalocyanines on breast cancer cell lines with photodynamic therapy
Bostancı,Hayrani Eren; Bilgiçli, Ahmet T.; Güzel,Emre; Günsel,Armağan; Hepokur, Ceylan; Çimen,Behzat; Yarasir,M. Nilüfer (2022)In this study, the new phthalonitrile derivative 3-(4-(3-oxobutyl)phenoxy)phthalonitrile (1) and its non peripheral metallophthalocyanine derivatives [zinc (2), copper (3), cobalt (4), manganese (5), gallium (6), and ... -
Evaluation of the effects of newly synthesized metallophthalocyanines on breast cancer cell lines with photodynamic therapy
Bostancı, Hayrani Eren; Bilgiçli, Ahmet Turgut; Güzel, Emre; Günsel, Armağan; Hepokur, Ceylan; Çimen, Behzat; Yaraşır, Meryem Nilüfer (Royal Society of Chemistry, 21.09.2022)In this study, the new phthalonitrile derivative 3-(4-(3-oxobutyl)phenoxy)phthalonitrile (1) and its nonperipheral metallophthalocyanine derivatives [zinc (2), copper (3), cobalt (4), manganese (5), gallium (6), and ... -
Fabric-Phase Sorptive Membrane Array As a Noninvasive In Vivo Sampling Device For Human Exposure To Different Compounds
Locatelli, Marcello; Tartaglia, Angela; Ulusoy, Halil İbrahim; Ulusoy, Songül; Savini, Fabio; Rossi, Sandra; Santavenere, Francesco; Merone. M, Giuseppe; Bassotti, Elisa; D’Ovidio, Cristian; Rosato, Enrica; Furton.G, Kenneth; Kabir,Abuzar (ACs, 20.01.2021)This study introduces an innovative device for the noninvasive sampling and chromatographic analysis of different compounds present in exhaled breath aerosol (EBA). The new sampling device, especially in light of the ... -
Güncel Uygulanan Kanser Tedavi Yöntemleri
Bostancı, Hayrani Eren (Bilgin Kültür Sanat Yayınları, 25.12.2022)Modern tıp her ne kadar ilerlemiş olsa da kanser için hastalık görülmeden önce ortaya çıkarılması ve erken safhada önlenmesi hala çok önemlidir. Kansere karşı koruyucu olarak; en büyük nedenlerinden biri olan sigara ve ... -
Imidazole‐hydrazone derivatives: Synthesis, characterization, X‐ray structures and evaluation of anticancer and carbonic anhydrase I–II inhibition properties
Eczacılık Fakültesi (19.06.2023)The nine new imidazole-hydrazone derivatives of Schiff base were synthesized from the condensation reactions of 1-methyl1H-imidazole-2-carbaldehyde with various substitutedhydrazide derivatives. Structures of the final ... -
Imidazole‐hydrazone derivatives: Synthesis, characterization, X‐ray structures and evaluation of anticancer and carbonic anhydrase I–II inhibition properties
Hakan Ünver; Ulviye Acar Cevik; Hayrani Eren Bostancı; Oğuzhan Kaya; Ümit M Kocyigit (Chemistry Europe, 2023/7/20)The nine new imidazole-hydrazone derivatives of Schiff base were synthesized from the condensation reactions of 1-methyl1H-imidazole-2-carbaldehyde with various substitutedhydrazide derivatives. Structures of the final ...