Elevated Serum CD95/FAS and HIF-1 alpha Levels, but Not Tie-2 Levels, May Be Biomarkers in Patients With Severe Endometriosis: A Preliminary Report
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Study Objective: To evaluate serum values of cluster of differentiation 95 (CD95/FAS), hypoxia-inducible factor 1-alpha (HIF-1 alpha), and tyrosine kinase receptor 2 (Tie-2) as possible biomarkers of disease presence and severity in women with endometriosis, and to characterize the changes in these values in women with stage I/II and stage III/IV endometriosis. Design: Prospective study (Canadian Task Force classification I). Setting: University hospital. Patients: Thirty women with endometriosis and 30 healthy women without endometriosis. Intervention: For the diagnosis of endometriosis and prediction of its severity, we measured the serum levels of CD95/FAS, which assess apoptotic conditions, and of HIF-1 alpha and Tie-2, which assess angiogenesis. Endometriosis was diagnosed and staged through surgical laparoscopy and later confirmed histologically. During the surgery, the patients with endometriosis were divided into 2 groups based on disease stage. Eleven patients had stage I/II endometriosis, and 19 had stage III/IV endometriosis. Measurements and Main Results: Endometriosis was associated with increased serum CD95/FAS and HIF-1 alpha levels, but not Tie-2 levels. We also determined that stage III/IV endometriosis was associated with higher serum CD95/FAS and HIF-1 alpha levels, but not Tie-2 levels, compared with stage I/II endometriosis. Conclusion: Endometriosis, in accordance with its severity, increases serum CD95/FAS and HIF-1 alpha levels, but not Tie-2 levels. These biomarkers may be useful for reproductive surgeons to improve the quality of counseling women about the presence and severity of endometriosis. (C) 2016 AAGL. All rights reserved.
SourceJOURNAL OF MINIMALLY INVASIVE GYNECOLOGY
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