dc.contributor.author | Karakus, Savas | |
dc.contributor.author | Sancakdar, Enver | |
dc.contributor.author | Akkar, Ozlem | |
dc.contributor.author | Yildiz, Caglar | |
dc.contributor.author | Demirpence, Ozlem | |
dc.contributor.author | Cetin, Ali | |
dc.date.accessioned | 2019-07-27T12:10:23Z | |
dc.date.accessioned | 2019-07-28T09:45:34Z | |
dc.date.available | 2019-07-27T12:10:23Z | |
dc.date.available | 2019-07-28T09:45:34Z | |
dc.date.issued | 2016 | |
dc.identifier.issn | 1553-4650 | |
dc.identifier.issn | 1553-4669 | |
dc.identifier.uri | https://dx.doi.org/10.1016/j.jmig.2016.01.025 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12418/7360 | |
dc.description | WOS: 000375821000021 | en_US |
dc.description | PubMed ID: 26851415 | en_US |
dc.description.abstract | Study Objective: To evaluate serum values of cluster of differentiation 95 (CD95/FAS), hypoxia-inducible factor 1-alpha (HIF-1 alpha), and tyrosine kinase receptor 2 (Tie-2) as possible biomarkers of disease presence and severity in women with endometriosis, and to characterize the changes in these values in women with stage I/II and stage III/IV endometriosis. Design: Prospective study (Canadian Task Force classification I). Setting: University hospital. Patients: Thirty women with endometriosis and 30 healthy women without endometriosis. Intervention: For the diagnosis of endometriosis and prediction of its severity, we measured the serum levels of CD95/FAS, which assess apoptotic conditions, and of HIF-1 alpha and Tie-2, which assess angiogenesis. Endometriosis was diagnosed and staged through surgical laparoscopy and later confirmed histologically. During the surgery, the patients with endometriosis were divided into 2 groups based on disease stage. Eleven patients had stage I/II endometriosis, and 19 had stage III/IV endometriosis. Measurements and Main Results: Endometriosis was associated with increased serum CD95/FAS and HIF-1 alpha levels, but not Tie-2 levels. We also determined that stage III/IV endometriosis was associated with higher serum CD95/FAS and HIF-1 alpha levels, but not Tie-2 levels, compared with stage I/II endometriosis. Conclusion: Endometriosis, in accordance with its severity, increases serum CD95/FAS and HIF-1 alpha levels, but not Tie-2 levels. These biomarkers may be useful for reproductive surgeons to improve the quality of counseling women about the presence and severity of endometriosis. (C) 2016 AAGL. All rights reserved. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | ELSEVIER SCIENCE INC | en_US |
dc.relation.isversionof | 10.1016/j.jmig.2016.01.025 | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | CD95/FAS | en_US |
dc.subject | HIF-1 alpha | en_US |
dc.subject | Tie-2 | en_US |
dc.subject | Endometriosis | en_US |
dc.title | Elevated Serum CD95/FAS and HIF-1 alpha Levels, but Not Tie-2 Levels, May Be Biomarkers in Patients With Severe Endometriosis: A Preliminary Report | en_US |
dc.type | article | en_US |
dc.relation.journal | JOURNAL OF MINIMALLY INVASIVE GYNECOLOGY | en_US |
dc.contributor.department | [Karakus, Savas -- Akkar, Ozlem -- Yildiz, Caglar -- Cetin, Ali] Cumhuriyet Univ, Sch Med, Dept Obstet & Gynecol, TR-58140 Sivas, Turkey -- [Sancakdar, Enver -- Demirpence, Ozlem] Cumhuriyet Univ, Sch Med, Dept Biochem, Sivas, Turkey | en_US |
dc.contributor.authorID | Cetin, Ali -- 0000-0002-5767-7894 | en_US |
dc.identifier.volume | 23 | en_US |
dc.identifier.issue | 4 | en_US |
dc.identifier.endpage | 577 | en_US |
dc.identifier.startpage | 573 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |