Lymphocytopenia is associated with poor NYHA functional class in chronic heart failure patients with reduced ejection fraction
Küçük Resim Yok
Tarih
2015
Yazarlar
Yucel, Hasan
Ege, Meltem Refiker
Zorlu, Ali
Kaya, Hakki
Beton, Osman
Gungor, Hasan
Acar, Gurkan
Temizhan, Ahmet
Cavusoglu, Yuksel
Zoghi, Mehdi
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
TURKISH SOC CARDIOLOGY
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Objective: In heart failure (HF) patients, functional capacity has been demonstrated to be a marker of poor prognosis, independent of left ventricular ejection fraction (EF). Lymphocyte count is currently recognized in certain risk stratification scores for chronic HF, and severe HF is associated with lymphocytopenia. However, no data exists on the association between lymphocyte count and functional capacity in patients with stable HF. This study aimed to assess the relationship between lymphocyte count and New York Heart Association (NYHA) functional capacity in systolic HF outpatients. Methods: The Turkish Research Team-HF (TREAT-HF) is a network which undertakes multi-center observational studies in HF. Data on 392 HF reduced ejection fraction (HFREF) patients from 8 HF centers are presented here. The patients were divided into two groups and compared: Group 1 comprised stable HFREF patients with mild symptoms NYHA Class (I-II), while Group 2 consisted of patients with NYHA Class III-IV symptoms. Results: Patient mean age was 60 +/- 14 years. Lymphocyte count was lower in patients with NYHA functional classes III and IV than in patients with NYHA functional classes I and II, 0.9 [0.6-1.5] x1000 versus 1.5 [0.7-2.2] x1000, p<0.001). In multivariate logistic regression analysis, lymphocyte count OR: 0.602, 95% CI: 0.375-0.967, p=0.036), advanced age, male gender, presence of hypertension, EF, left atrium size, systolic pulmonary artery pressure, neutrophil and basophil counts, creatinine level, and diuretic usage were associated with poor NYHA functional class in systolic HF outpatients. Conclusion: The present study demonstrated that in stable HFREF outpatients, lymphocytopenia was strongly associated with poor NYHA function, independent of coronary heart disease risk factors.
Açıklama
Anahtar Kelimeler
Heart failure, lymphocyte, lymphocytopenia, NYHA functional class
Kaynak
TURK KARDIYOLOJI DERNEGI ARSIVI-ARCHIVES OF THE TURKISH SOCIETY OF CARDIOLOGY
WoS Q Değeri
N/A
Scopus Q Değeri
Q4
Cilt
43
Sayı
5
