Does mammalian target of rapamycin or sestrin 1 protein signaling have a role in bone fracture healing?

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dc.contributor.authorPazarci, Ozhan
dc.contributor.authorDogan, Halef Okan
dc.contributor.authorKilinc, Seyran
dc.contributor.authorCamurcu, Ismet Yalkin
dc.date.accessioned2024-10-26T18:00:04Z
dc.date.available2024-10-26T18:00:04Z
dc.date.issued2019
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractBackground/aim: Fracture healing is a complex physiological process that involves a well-orchestrated series of biological events. The mammalian target of rapamycin (mTOR) and sestrin 1 (SESN 1) play a central role in cell metabolism, proliferation, and survival. The aim of our study is to present serum mTOR and SESN 1 levels by comparing patients with or without bone fractures. It is also a guide for further research on the roles of these proteins in fracture healing. Materials and methods: A total of 34 patients (10 females, 24 males) with bone fractures and 32 controls (10 females, 22 males) participated in this study. After collecting serum venous blood samples, the quantitative sandwich ELISA technique was used for the determination of serum mTOR and SESN 1 levels. Results: The mean serum mTOR level was significantly higher in the fracture group compared to the control group (P = 0.001). However, SESN 1 levels did not significantly differ between groups (p = 0.913). Conclusion: We found that serum mTOR levels increased on the first day after fracture compared to the control group. However, we obtained no significant difference between groups in terms of SESN 1 levels. This study may guide further clinical studies investigating the potential role of mTOR signaling in the bone healing process.
dc.description.sponsorshipScientific Research Projects Fund of Cumhuriyet University [T724]; Austrian Science Fund (FWF) [T724] Funding Source: Austrian Science Fund (FWF)
dc.description.sponsorshipThis work was supported by the Scientific Research Projects Fund of Cumhuriyet University under Project Number T724.
dc.identifier.doi10.3906/sag-1809-117
dc.identifier.endpage1778
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.issue6
dc.identifier.pmid31655537
dc.identifier.scopus2-s2.0-85076874641
dc.identifier.scopusqualityQ3
dc.identifier.startpage1774
dc.identifier.trdizinid337073
dc.identifier.urihttps://doi.org/10.3906/sag-1809-117
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/337073
dc.identifier.urihttps://hdl.handle.net/20.500.12418/27507
dc.identifier.volume49
dc.identifier.wosWOS:000504051300026
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTubitak Scientific & Technological Research Council Turkey
dc.relation.ispartofTurkish Journal of Medical Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectmTOR
dc.subjectsestrin
dc.subjectbone
dc.subjectfracture
dc.titleDoes mammalian target of rapamycin or sestrin 1 protein signaling have a role in bone fracture healing?
dc.typeArticle

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