BIOLOGICAL ACTIVITY EVALUATION OF THREE Hypericum L. SPECIES

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dc.authoridCevik, Ozge/0000-0002-9325-3757
dc.authoridAtas, Mehmet/0000-0002-9425-0080
dc.authorid, Nuraniye/0000-0002-4674-7009
dc.contributor.authorEruygur, Nuraniye
dc.contributor.authorOzpinar, Necati
dc.contributor.authorOzpinar, Hulya
dc.contributor.authorAtas, Mehmet
dc.contributor.authorTekin, Mehmet
dc.contributor.authorCevik, Ozge
dc.date.accessioned2024-10-26T18:00:35Z
dc.date.available2024-10-26T18:00:35Z
dc.date.issued2022
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractThis study was performed in order to evaluate in vitro antioxidant, anti-Trichomonas vaginalis, antimicrobial and cytotoxic activities of methanol extracts of aerial parts of Hypericum perforatum L., H. thymbrifolium Boiss. & Noe and H. thymopsis Boiss. The antioxidant activity of methanol extracts was tested with 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2 '-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radical scavenging and iron chelating assays. The total phenol and flavonoid contents were also determined spectrophotometrically. Cytotoxicity and apoptosis were evaluated on MCF-7 breast cancer and PC3 prostate cancer cell line. Antimicrobial activities were evaluated by the microdilution method on the bacterial strains Staphylococcus aureus (ATCC 29213), Enterococcus faecalis (ATCC 29212), Pseudomonas aeruginosa (ATCC 27853) Escherichia coli (ATCC 25922) and the fungal strain Candida albicans (ATCC 10231). All extracts demonstrated cytotoxic activity on PC3 prostat cancer cell line with a concentration dependent manner, while H. thymopsis extract was the most active against cancer cell growth. The obtained results of the present study revealed that the methanol extract of H. perforatum, H. thymbrifolium and H. thymopsis have significant antioxidant and cytotoxic activities. The results provided the basic research data for further phytochemical and biological activity guided investigations on these species for identication and isolation of potential drug active compounds.
dc.description.sponsorshipScientific Research Foundation of Sivas Cumhuriyet University; [ECZ-020]
dc.description.sponsorshipFunding: The authors express their sincere gratitude to Scientific Research Foundation of Sivas Cumhuriyet University for their financial support of the study with the project number ECZ-020.
dc.identifier.doi10.23902/trkjnat.1043241
dc.identifier.endpage134
dc.identifier.issn2528-9691
dc.identifier.issue2
dc.identifier.scopus2-s2.0-85205591066
dc.identifier.scopusqualityN/A
dc.identifier.startpage125
dc.identifier.trdizinid1134509
dc.identifier.urihttps://doi.org/10.23902/trkjnat.1043241
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1134509
dc.identifier.urihttps://hdl.handle.net/20.500.12418/27765
dc.identifier.volume23
dc.identifier.wosWOS:000878534200002
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherTrakya Univ Balkan Yerlesesi Enstituler Binasi
dc.relation.ispartofTrakya University Journal of Natural Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectHypericum perforatum
dc.subjectHypericum thymbrifolium
dc.subjectHypericum thymopsis
dc.subjectAntioxidant
dc.subjectAnti-Trichomonas
dc.subjectAntimicrobial
dc.subjectCytotoxicity
dc.titleBIOLOGICAL ACTIVITY EVALUATION OF THREE Hypericum L. SPECIES
dc.typeArticle

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