The relationship between ASIC3 gene polymorphism and fibromyalgia syndrome

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dc.authoridTAS, Ayca/0000-0002-7132-1325
dc.authoridZONTUL, Cemile/0000-0002-1436-5145
dc.authoridSilig, Yavuz/0000-0002-0562-7457
dc.contributor.authorZontul, Cemile
dc.contributor.authorTas, Ayca
dc.contributor.authorHayta, Emrullah
dc.contributor.authorSilig, Yavuz
dc.date.accessioned2024-10-26T18:09:14Z
dc.date.available2024-10-26T18:09:14Z
dc.date.issued2024
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractObjectives: Fibromyalgia syndrome (FMS) is a chronic pain syndrome characterized by widespread body pain over a long period, the cause of which is not yet clearly known. FMS patients usually have high pain sensitivity. We aimed to investigate whether rs4148855 and rs2288646 polymorphisms of acid-sensing ion channel 3 (ASIC3), one of the factors contributing to pain, cause a predisposition to FMS in the Turkish population.Methods: ASIC3 gene rs4148855 and rs2288646 polymorphisms in DNA samples obtained from blood samples of 175 patients with FMS and 176 healthy individuals were analyzed by real-time polymerase chain reaction (RT-PCR) using a hydrolysis probe. Statistical data were obtained by chi-square (chi(2)) test and logistic regression analysis.Results: No significant association was found between ASIC3 gene rs4148855 and rs2288646 polymorphisms and the Turkish population's FMS group and control group (p>0.05).Conclusions: As a result, no significant association was found between the genotype and allele distributions of ASIC3 polymorphism (rs4148855 and rs2288646) in patients with FMS compared to controls in the Turkish population. Further studies are needed to elucidate the relationship between ion channels and FMS to elucidate the mechanisms of FMS.
dc.description.sponsorshipThe authors thank to Dr Ziynet Cinar for her assistance with the statistical analysis.
dc.description.sponsorshipThe authors thank to Dr Ziynet Cinar for her assistance with the statistical analysis.
dc.identifier.doi10.1515/tjb-2023-0101
dc.identifier.endpage130
dc.identifier.issn0250-4685
dc.identifier.issn1303-829X
dc.identifier.issue1
dc.identifier.scopus2-s2.0-85187918273
dc.identifier.scopusqualityQ4
dc.identifier.startpage123
dc.identifier.trdizinid1282440
dc.identifier.urihttps://doi.org/10.1515/tjb-2023-0101
dc.identifier.urihttps://hdl.handle.net/20.500.12418/30010
dc.identifier.volume49
dc.identifier.wosWOS:001087133800001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherWalter De Gruyter Gmbh
dc.relation.ispartofTurkish Journal of Biochemistry-Turk Biyokimya Dergisi
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectfibromyalgia syndrome
dc.subjectsingle nucleotide polymorphism
dc.subjectacid-sensing ion channel 3
dc.subjectTurkish population
dc.titleThe relationship between ASIC3 gene polymorphism and fibromyalgia syndrome
dc.typeArticle

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