Serum NOX-2 concentrations and paraoxanase-1 activity in subclinical hypothyroidism: a pilot study

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dc.authoridDuman, Gulhan/0000-0002-4057-5701
dc.contributor.authorDuman, Gulhan
dc.contributor.authorDugan, Halef Okan
dc.date.accessioned2024-10-26T18:00:20Z
dc.date.available2024-10-26T18:00:20Z
dc.date.issued2020
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractObjective: Subclinical hypothyroidism (SH) is one of the most prevalent endocrine disorders. Although recent data suggest an imbalanced oxidative status in SH, the mechanisms of increased oxidative stress are poorly figured out. The primary goal of this research was to analyze potential sources of ROS and the relationship between serum NOX-2 levels and paraoxonase-1 (PON-1) activity in SH. Serum lipid changes in SH patients which had been determined were compared to healthy control group. Materials and methods: Thirty-one patients diagnosed with SI' and 30 healthy controls were included in the study. The quantitative sandwich ELISA was used for the detection of serum NOX-2 levels. Spectrophotometric method was used to determine serum PON-1 activity. Results: higher median serum NOX-2 levels were determined in patients than in the control group (p= 0.004). Lower median serum PON-1 activity was determined in patients as to aforementioned control group (p<0.0001). As a consequence, no statistically remarkable correlation was identified between PON-1 activity and NOX-2 levels. Triglyceride (TG) concentrations were determined as superior in patients to control group (p <0.0001). Conclusion: Over-production of NOX-2 and decreased PON-1 activity contribute to the increased oxidative stress in SH patients. Larger prospective studies required to confirm these findings.
dc.identifier.doi10.1515/tjb-2018-0159
dc.identifier.endpage276
dc.identifier.issn0250-4685
dc.identifier.issn1303-829X
dc.identifier.issue3
dc.identifier.scopus2-s2.0-85090434657
dc.identifier.scopusqualityQ4
dc.identifier.startpage271
dc.identifier.trdizinid457569
dc.identifier.urihttps://doi.org/10.1515/tjb-2018-0159
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/457569
dc.identifier.urihttps://hdl.handle.net/20.500.12418/27643
dc.identifier.volume45
dc.identifier.wosWOS:000582566800006
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherWalter De Gruyter Gmbh
dc.relation.ispartofTurkish Journal of Biochemistry-Turk Biyokimya Dergisi
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectSubclinical hypothyroidism
dc.subjectNADPH oxidase
dc.subjectTriglyceride
dc.subjectParaoxonase
dc.subjectOxidative stress
dc.titleSerum NOX-2 concentrations and paraoxanase-1 activity in subclinical hypothyroidism: a pilot study
dc.typeArticle

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