Roles of Therapeutic Bioactive Compounds in Hepatocellular Carcinoma

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dc.authorid0000-0003-4946-5602tr
dc.contributor.authorDurna Daştan, Sevgi
dc.contributor.authorjain, divya
dc.contributor.authorMurti, Yogesh
dc.contributor.authorKhan, Vasi Ullah
dc.contributor.authorhossain, rajib
dc.contributor.authorhossain, MOhammed Nabil
dc.contributor.authorAgraval, Krish Kumar
dc.contributor.authorAshraf, Rana Azem
dc.contributor.authorIslam, Muhammed toregul
dc.contributor.authorJanmeda, Pracheta
dc.contributor.authortahari, yasaman
dc.contributor.authorAl-shehri, Mohammed
dc.contributor.authorYeskaliyeva, balakyz
dc.contributor.authorKıpchakheyeva, aliyeva
dc.contributor.authorRad, Javad sharifi
dc.contributor.authorCho, William c
dc.date.accessioned2022-05-13T13:28:17Z
dc.date.available2022-05-13T13:28:17Z
dc.date.issued2021tr
dc.departmentFen Fakültesitr
dc.description.abstractHepatocellular carcinoma (HCC) is due to poor prognosis and lack of availability of effective treatment. Novel therapeutic strategies will be the fine tuning of intracellular ROS signaling to effectively deprive cells of ROS-induced tumor-promoting events. This review discusses the generation of ROS, the major signaling their modulation in therapeutics. We explore some of the major pathways involved in HCC, which include the VEGF, MAPK/ERK, mTOR, FGF, and Ser/Thr kinase pathways. In this review, we study cornerstone on natural bioactive compounds with their effect on hepatocarcinomas. Furthermore, we focus on oxidative stress and FDA-approved signaling pathway inhibitors, along with chemotherapy and radiotherapy enhancers which with early evidence of success. While more in vivo testing is required to confirm the findings presented here, our findings will aid future nonclinical, preclinical, and clinical studies with these compounds, as well as inspire medicinal chemistry scientists to conduct appropriate research on this promising natural compound and their derivatives.tr
dc.identifier.doi10.1155/2021/9068850en_US
dc.identifier.pmid34754365en_US
dc.identifier.scopus2-s2.0-85118989123en_US
dc.identifier.scopusqualityN/A
dc.identifier.urihttps://hdl.handle.net/20.500.12418/13101
dc.identifier.wosWOS:001255304500001en_US
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofOxidative Medicine and Cellular Longevityen_US
dc.relation.publicationcategoryUluslararası Hakemli Dergide Makale - Kurum Öğretim Elemanıtr
dc.rightsinfo:eu-repo/semantics/closedAccesstr
dc.titleRoles of Therapeutic Bioactive Compounds in Hepatocellular Carcinomaen_US
dc.typeArticleen_US

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