Serum Calcitonin Gene-Related Peptide and Receptor Protein Levels in Patients With Fibromyalgia Syndrome: A Cross-Sectional Study

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dc.authoridSilig, Yavuz/0000-0002-0562-7457
dc.authoridTAS, Ayca/0000-0002-7132-1325
dc.authoridKORUCU, Ragip Ulvi/0000-0002-0131-6846
dc.authoridKARADAG, Ahmet/0000-0002-5284-2256
dc.contributor.authorKorucu, Ragip Ulvi
dc.contributor.authorKaradag, Ahmet
dc.contributor.authorTas, Ayca
dc.contributor.authorOzmen, Esma
dc.contributor.authorHayta, Emrullah
dc.contributor.authorSilig, Yavuz
dc.date.accessioned2024-10-26T18:00:19Z
dc.date.available2024-10-26T18:00:19Z
dc.date.issued2020
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractObjectives: This study aims to compare the serum calcitonin gene-related peptide (CGRP) and CGRP receptor protein levels between patients with fibromyalgia syndrome (FM) and healthy control subjects. Patients and methods: The study included 88 patients (7 males, 81 females; mean age 44.5 +/- 9.1 years; range, 20 to 72 years) newly-diagnosed with FM according to the 2010 American College of Rheumatology criteria and 88 healthy volunteers (6 males, 82 females; mean age 43.0 +/- 6.1 years; range, 20 to 57 years). Venous blood samples were collected from both groups for the measurement of the levels of serum CGRP and CGRP receptor proteins (receptor component protein [RCP], receptor activity modifying protein 1 [RAMP 1] and calcitonin receptor-like receptor [CLR]). Results: A comparison of the serum CGRP, CLR and RCP levels of the FM and control groups revealed a statistically significant difference (p=0.001, p=0.005, p=0.001, respectively). The difference between the groups in respect of the serum RAMP 1 levels was not statistically significant (p=0.107). Conclusion: The serum CGRP, CLR and RCP levels were found to be higher in the FM patients, but no difference was determined between the FM patients and the healthy control group in respect of the RAMP 1 level. These results can be of guidance for further clinical studies of the etiopathogenesis and treatment of FM.
dc.description.sponsorshipScientific Research Project Fund of Cumhuriyet University [T788]; Austrian Science Fund (FWF) [T788] Funding Source: Austrian Science Fund (FWF)
dc.description.sponsorshipThis study was supported by the Scientific Research Project Fund of Cumhuriyet University (project No. T788).
dc.identifier.doi10.46497/ArchRheumatol.2020.7783
dc.identifier.endpage467
dc.identifier.issn2148-5046
dc.identifier.issn1309-0283
dc.identifier.issue4
dc.identifier.pmid33758802
dc.identifier.scopus2-s2.0-85097832962
dc.identifier.scopusqualityQ4
dc.identifier.startpage463
dc.identifier.trdizinid457515
dc.identifier.urihttps://doi.org/10.46497/ArchRheumatol.2020.7783
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/457515
dc.identifier.urihttps://hdl.handle.net/20.500.12418/27640
dc.identifier.volume35
dc.identifier.wosWOS:000595829400001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTurkish League Against Rheumatism
dc.relation.ispartofArchives of Rheumatology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCalcitonin gene-related peptide
dc.subjectfibromyalgia
dc.subjectpain
dc.subjectreceptor proteins
dc.titleSerum Calcitonin Gene-Related Peptide and Receptor Protein Levels in Patients With Fibromyalgia Syndrome: A Cross-Sectional Study
dc.typeArticle

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