Recent approaches in topical acne treatment and drug delivery

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dc.contributor.authorGunaydin, Aysu
dc.contributor.authorEsenturk-Guzel, Imren
dc.contributor.authorAlgin Yapar, Evren
dc.contributor.authorYurdasiper, Aysu
dc.date.accessioned2024-10-26T18:00:42Z
dc.date.available2024-10-26T18:00:42Z
dc.date.issued2022
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractAcne vulgaris is a widespread chronic disease of the hair follicles associated with the sebaceous glands. Disease factors include occlusion of follicles, hyperkeratinizations, keratin plug formation, enlargement of the sebum gland and increased sebum production. The selection of drugs to be applied in acne treatment is made according to criteria such as the degree of acne lesions, the preferred route of administration, and the patient's medical condition. With its large surface area, the skin is a high potential route for drug release, so topical agents have a wide range of uses. However, these agents often have disadvantages such as dry skin, peeling and skin irritation or bacterial resistance. In order to minimize these disadvantages, new drug delivery systems have been developed. Drug delivery systems are biocompatible systems that enable the transport of molecules for pharmaceutical applications. These systems are usually designed at nanometric and micrometric levels for purposes such as increasing site specificity and penetration. Topical drug delivery systems are preferred due to eliminating the need for systemic drug treatments, minimizing the total dose required to reach the targeted layers in the skin, and reducing side effects. Nanotechnological approaches such as particulate, vesicular, colloidal drug delivery systems and various other systems have an important place in the treatment of acne. These approaches offer significant opportunities for designing novel, low-dose and effective treatment systems to control acne. In this review, recent approaches to topical acne treatments and drug delivery have been overviewed.
dc.identifier.doi10.29228/jrp.248
dc.identifier.endpage1554
dc.identifier.issn2630-6344
dc.identifier.issue6
dc.identifier.scopus2-s2.0-85142124270
dc.identifier.scopusqualityQ3
dc.identifier.startpage1539
dc.identifier.trdizinid1175940
dc.identifier.urihttps://doi.org/10.29228/jrp.248
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1175940
dc.identifier.urihttps://hdl.handle.net/20.500.12418/27809
dc.identifier.volume26
dc.identifier.wosWOS:000893010600004
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherMarmara Univ
dc.relation.ispartofJournal of Research in Pharmacy
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAcne vulgaris
dc.subjecttopical treatment
dc.subjectnanocarrier systems
dc.subjectdrug delivery
dc.titleRecent approaches in topical acne treatment and drug delivery
dc.typeReview Article

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