Platelet activating factor acetylhydrolase is associated with cardiac valvular calcification in dialysis patients

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dc.authoridbolat, serkan/0000-0002-8669-8782
dc.authoridYucel, Dogan/0000-0001-5487-2857
dc.authoridelcik, deniz/0000-0003-0992-1415
dc.authoridDuranay, Murat/0000-0002-2893-4484
dc.contributor.authorBolat, Serkan
dc.contributor.authorFidanci, Vildan
dc.contributor.authorElcik, Deniz
dc.contributor.authorTomar, Ozdem Kavraz
dc.contributor.authorMurat, Sani Namik
dc.contributor.authorDuranay, Murat
dc.contributor.authorYucel, Dogan
dc.date.accessioned2024-10-26T18:01:59Z
dc.date.available2024-10-26T18:01:59Z
dc.date.issued2024
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractObjectives The cardiovascular mortality risk is greatly increased in patients with chronic kidney disease (CKD), especially in dialysis patients, due to atherosclerosis. Platelet activating factor acetylhydrolase (PAF-AH) is an enzyme that hydrolyzes platelet activating factor (PAF). Valvular calcifications and PAF-AH are associated with atherosclerosis. However, little is known about the status of PAF-AH activity and valvular calcification in dialysis patients. Therefore, the aim of this study was to investigate the status of these parameters in CKD patients. Methods This study included 92 chronic renal failure (CRF) (dialysis group), and 86 CKD patients (non-dialysis group). Echocardiography was performed to assess valvular calcification. Results There was no significant difference between the dialysis and CKD groups in terms of PAF-AH activities. However, when comparisons were stratified according to the presence of valve calcification, higher PAF-AH activity and N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels were evident in patients with calcification compared to those without. Additionally, the CRF group also exhibited elevated PAF-AH and NT-proBNP levels. While elevated NT-proBNP persisted in the CKD group, in contrast, changes in PAF-AH were not significant. Conclusions The results of this study suggest that high PAF-AH and NT-proBNP levels are associated with valvular calcification in dialysis patients. Both biomarkers may be used as a risk factor for calcification. Furthermore, inhibition of PAF-AH activity may be a treatment target to reduce calcification.
dc.identifier.doi10.1515/tjb-2023-0263
dc.identifier.endpage282
dc.identifier.issn0250-4685
dc.identifier.issn1303-829X
dc.identifier.issue2
dc.identifier.scopus2-s2.0-85193235922
dc.identifier.scopusqualityQ4
dc.identifier.startpage274
dc.identifier.trdizinid1243906
dc.identifier.urihttps://doi.org/10.1515/tjb-2023-0263
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1243906
dc.identifier.urihttps://hdl.handle.net/20.500.12418/27873
dc.identifier.volume49
dc.identifier.wosWOS:001178217200001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherWalter De Gruyter Gmbh
dc.relation.ispartofTurkish Journal of Biochemistry-Turk Biyokimya Dergisi
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjecthemodialysis
dc.subjectperitoneal dialysis
dc.subjectcalcification
dc.subjectPAF-AH
dc.subjectNT-proBNP
dc.titlePlatelet activating factor acetylhydrolase is associated with cardiac valvular calcification in dialysis patients
dc.typeArticle

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