ANTI-INFLAMMATORY AND ANTIOXIDANT EFFECT OF ALLIUM SCORODOPRASUM L. ETHANOLIC EXTRACT (ASE) IN MICE

Basit Öğe Kaydı
dc.authorid0000-0002-5195-9372tr
dc.contributor.authorEkici, Mehmet
dc.contributor.authorGüngör, Hüseyin
dc.contributor.authorDemir, Tuğba
dc.contributor.authorAteş, Mehmet Burak
dc.contributor.authorKumru, Alper Serhat
dc.date.accessioned2023-04-12T05:21:51Z
dc.date.available2023-04-12T05:21:51Z
dc.date.issuedOctober, 2022tr
dc.departmentVeteriner Fakültesitr
dc.description.abstractThe antioxidant and anti-inflammatory properties of Allium species plants have been reported in studies. However, no study was found showing the antioxidant and anti-inflammatory properties of Allium scorodoprasum L. ethanolic extract (ASE) in the experimental carrageenan (Carr) induced paw edema mice model. This study aimed to investigate the antioxidant and anti-inflammatory effects of ASE in Carr-induced paw edema mice model. The polyphenolic compounds of ASE were analyzed with HPLC. A total of 30 male Balb/C mice were randomly divided into Control, Carr, Carr + Diclofenac Sodium, Carr + ASE200, Carr + ASE400, and Carr + ASE600 groups (n=5/group). The mice paw edema was induced by 0.05 ml subplantar injection of 1% Carr. Different groups of mice with Carr-induced paw edema were administered by oral gavage with 10 mg/kg Diclofenac Sodium and 200, 400, and 600 mg/kg ASE, respectively. Orally administered ASE at 400 and 600 mg/kg significantly decreased paw swelling, and serum levels of TNF-α, IL-1β, IL-6, AST, ALT, and ALP. ASE also decreased MDA levels and total oxidant status (TOS) but increased total antioxidant status (TAS) in the liver. In addition, ASE decreased paw and liver histopathologic values and neutrophil counts in paw tissues. The results of this study showed that ASE has an anti-inflammatory and antioxidant effect through strong polyphenolic compounds.tr
dc.description.sponsorshipCÜBAP; V-093tr
dc.identifier.citationEkici, M., Güngör, H., Demir, T., Ateş, M. B., & Kumru, A. S. (2022). ANTI-INFLAMMATORY AND ANTIOXIDANT EFFECT OF ALLIUM SCORODOPRASUM L. ETHANOLIC EXTRACT (ASE) IN MICE. JAPS: Journal of Animal & Plant Sciences, 32(5).tr
dc.identifier.doi10.36899/JAPS.2022.5.0529en_US
dc.identifier.endpage1238tr
dc.identifier.issn1018-7081/2309-8694
dc.identifier.issue5tr
dc.identifier.scopus2-s2.0-85139491117en_US
dc.identifier.scopusqualityQ4
dc.identifier.startpage1229tr
dc.identifier.urihttps://hdl.handle.net/20.500.12418/13560
dc.identifier.volume32tr
dc.identifier.wosWOS:000892888100001en_US
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherJAPStr
dc.relation.ispartofJournal of Animal and Plant Sciencesen_US
dc.relation.publicationcategoryUluslararası Hakemli Dergide Makale - Kurum Öğretim Elemanıtr
dc.rightsinfo:eu-repo/semantics/openAccesstr
dc.subjectAllium scorodoprasum L.tr
dc.subjectantioxidanttr
dc.subjectanti-inflammatorytr
dc.subjectcarrageenantr
dc.subjectpaw edematr
dc.subjectmicetr
dc.titleANTI-INFLAMMATORY AND ANTIOXIDANT EFFECT OF ALLIUM SCORODOPRASUM L. ETHANOLIC EXTRACT (ASE) IN MICEen_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
ANTI-INFLAMMATORY AND ANTIOXIDANT EFFECT OF ALLIUM SCORODOPRASUM.pdf
Boyut:
1.19 MB
Biçim:
Adobe Portable Document Format
Açıklama:
MAKALE DOSYASI
İndir
Lisans paketi
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
license.txt
Boyut:
1.44 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
İndir

Koleksiyon

Besin - Gıda Hijyeni ve Teknolojisi Bölümü Makale Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu