Serum Calprotectin and Iron Metabolism Biomarker Levels in Behcet's Disease

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dc.authoridDOGAN, Halef Okan/0000-0001-8738-0760
dc.authoridKARADAG, Ahmet/0000-0002-5284-2256
dc.contributor.authorKaradag, Ahmet
dc.contributor.authorDogan, Halef Okan
dc.date.accessioned2024-10-26T18:00:30Z
dc.date.available2024-10-26T18:00:30Z
dc.date.issued2021
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractObjective: This study aimed to investigate the serum levels of calprotectin, hepcidin, iron, and ferritin in Behcet's disease (BD). Materials and Methods: This study included 40 patients with BD who met the diagnostic criteria of the BD International Study Group (1990) and 40 healthy control participants. Serum high-sensitive C-reactive protein (hsCRP), hepcidin, calprotectin, ferritin, iron, and unsaturated iron-binding capacity (UIBC) levels were determined in all study participants. Results: Statistically significant difference was found between the groups in respect of calprotectin (p<0.05), UIBC (p<0.05), hsCRP (p<0.05), and hemoglobin (p<0.05) levels. No statistically significant differences were determined between the patients and the controls in terms of hepcidin, iron, and ferritin levels. Cut-off value of 212.3 pg/mL for calprotectin was determined to identify patients with BD having a sensitivity and specificity of 100% and 90%, respectively. Conclusion: Serum calprotectin may be a useful biomarker in the evaluation of inflammatory status and BD diagnosis. Total iron-binding capacity and hemoglobin may be more useful in evaluating iron deficiency anemia in patients with BD.
dc.identifier.doi10.4274/tod.galenos.2021.45403
dc.identifier.endpage144
dc.identifier.issn2147-2653
dc.identifier.issue3
dc.identifier.scopus2-s2.0-85123835633
dc.identifier.scopusqualityQ4
dc.identifier.startpage140
dc.identifier.trdizinid527464
dc.identifier.urihttps://doi.org/10.4274/tod.galenos.2021.45403
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/527464
dc.identifier.urihttps://hdl.handle.net/20.500.12418/27722
dc.identifier.volume27
dc.identifier.wosWOS:000753766500003
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherGalenos Yayincilik
dc.relation.ispartofTurk Osteoporoz Dergisi-Turkish Journal of Osteoporosis
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectBehcet's disease
dc.subjectcalprotectin
dc.subjecthepcidin
dc.subjectiron
dc.subjectferritin
dc.titleSerum Calprotectin and Iron Metabolism Biomarker Levels in Behcet's Disease
dc.typeReview Article

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