The in-vitro Wound Healing Potential of Essential Oil Extracted from Mentha longifolia L.

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dc.authoridGulluce, Medine/0000-0002-5957-8259
dc.authoridBayram, Cemil/0000-0001-8940-8560
dc.contributor.authorSezen, Selma
dc.contributor.authorErtugrul, Muhammed Sait
dc.contributor.authorBayram, Cemil
dc.contributor.authorOzkaraca, Mustafa
dc.contributor.authorKoc, Taha Yasin
dc.contributor.authorDemir, Abdussamed Yasin
dc.contributor.authorGulluce, Medine
dc.date.accessioned2024-10-26T18:00:43Z
dc.date.available2024-10-26T18:00:43Z
dc.date.issued2023
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractProducts from Mentha species are widely used in medical applications, including wound healing, due to the bioactive compounds they may contain. However, data on the effect of Mentha longifolia L. on wound healing are limited. This study investigated the antimicrobial and wound healing-promoting effects of Mentha longifolia L. essential oil using in vitro methods. The chemical compositions of the essential oil were identified using gas chromatography/mass spectrometry, while the agar well diffusion and disk diffusion methods were used to determine antimicrobial activity against pathogenic strains. A scratch wound healing assay was performed following determination of the cytotoxic dose in human fibroblast cell lines. The media were used for biochemical analysis 48 h after the in vitro wound model. Immunohistochemical staining was applied to determine the contribution of the essential oil to wound healing. The essential oil exhibited varying levels of antimicrobial activity against the tested pathogens and increased cell viability. All doses in the scratch wound healing assay promoted wound closure in a shorter time than in the control group. TAC levels were higher in the treated groups than in the control group, while TOS, IL-6, and TNF-alpha levels were lower. Levels of expression of FGF 2, IGF, and TGF-beta were higher in the treated groups than in the control group at increasing doses. The essential oil of Mentha longifolia L. exhibited antimicrobial effects and improved wound healing at doses of 5 mu g/mL and 10 mu g/mL.
dc.identifier.doi10.29228/jrp.411
dc.identifier.endpage1233
dc.identifier.issn2630-6344
dc.identifier.issue3
dc.identifier.scopus2-s2.0-85161415254
dc.identifier.scopusqualityQ3
dc.identifier.startpage1220
dc.identifier.trdizinid1179499
dc.identifier.urihttps://doi.org/10.29228/jrp.411
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1179499
dc.identifier.urihttps://hdl.handle.net/20.500.12418/27820
dc.identifier.volume27
dc.identifier.wosWOS:001011434600020
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherMarmara Univ
dc.relation.ispartofJournal of Research in Pharmacy
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectMentha longifolia L
dc.subjectwound healing
dc.subjectfibroblast
dc.subjectessential oil
dc.subjectantimicrobial effect
dc.titleThe in-vitro Wound Healing Potential of Essential Oil Extracted from Mentha longifolia L.
dc.typeArticle

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