Evaluation of the Neurotoxicity of Strontium and Glycyrrhiza Glabra: First Report

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dc.authoridSahin-Bolukbasi, Serap/0000-0003-1057-2558
dc.contributor.authorSoylemez, Burcak
dc.contributor.authorSahin-Bolukbasi, Serap
dc.date.accessioned2024-10-26T18:03:54Z
dc.date.available2024-10-26T18:03:54Z
dc.date.issued2021
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractAIM: To investigate the neurotoxic effects of strontium (Sr) compounds and Glycyrrhiza glabra (licorice, G. glabra). MATERIAL and METHODS: In this study, we conducted neurotoxicity assays on the human cortical neuronal cell line HCN-2 (CRL-10742) to determine the potential neurotoxic effects of Sr and G. glabra. RESULTS: No significant decrease in HCN-2 cell viability was observed with longer Sr exposure or Sr concentrations up to 2000 mu g/mL. The IC50 values of Sr for 24 and 48 hours of exposure were >2000 mu g/mL, and 936.9 +/- 0.09 mu g/mL for 72 hours. However, we observed a significant reduction in HCN-2 cell viability with longer exposure and higher concentrations of G. glabra. The IC50 values of G. glabra for 24, 48, and 72 hours were 545.1 +/- 0.03 mu g/mL, 398.1 +/- 0.03 mu g/mL, and 393.3 +/- 0.02 mu g/mL, respectively. CONCLUSION: Additional studies are needed to further investigate the neurotoxicity of Sr and G. glabra, and elucidate the pathway by which these compounds exert their therapeutic effects in pathological conditions.
dc.identifier.doi10.5137/1019-5149.JTN.30290-20.2
dc.identifier.endpage509
dc.identifier.issn1019-5149
dc.identifier.issue4
dc.identifier.pmid33372255
dc.identifier.scopus2-s2.0-85110629815
dc.identifier.scopusqualityQ3
dc.identifier.startpage505
dc.identifier.urihttps://doi.org/10.5137/1019-5149.JTN.30290-20.2
dc.identifier.urihttps://hdl.handle.net/20.500.12418/28650
dc.identifier.volume31
dc.identifier.wosWOS:000672802600005
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTurkish Neurosurgical Soc
dc.relation.ispartofTurkish Neurosurgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectGlycyrrhiza glabra
dc.subjectNeurons
dc.subjectCell line
dc.subjectHuman Brain Cortical Neuronal Cell line
dc.subjectNeurotoxicity
dc.subjectStrontium
dc.titleEvaluation of the Neurotoxicity of Strontium and Glycyrrhiza Glabra: First Report
dc.typeArticle

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