Factors affecting parametrial involvement in cervical cancer patients with tumor size ?4 cm and selection of low-risk patient group

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dc.authoridGunakan, Emre/0000-0001-8854-8190
dc.authoridKucukyildiz, Irem/0000-0002-6604-0713
dc.authoridHABERAL REYHAN, ASUMAN NIHAN/0000-0001-9852-9911
dc.authoridTunc, Mehmet/0000-0002-8646-0619
dc.authoridTohma, Yusuf Aytac/0000-0001-9418-4733
dc.contributor.authorAkilli, Huseyin
dc.contributor.authorTohma, Yusuf Aytac
dc.contributor.authorGunakan, Emre
dc.contributor.authorKucukyildiz, Irem
dc.contributor.authorTunc, Mehmet
dc.contributor.authorHaberal, Nihan Reyhan
dc.contributor.authorAyhan, Ali
dc.date.accessioned2024-10-26T18:00:16Z
dc.date.available2024-10-26T18:00:16Z
dc.date.issued2021
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractObjective: The primary aim of this study was to evaluate the factors affecting parametrial involvement in cervical cancer patients with tumor size <= 4 cm and selection of the low-risk patient group based on long-term oncologic outcomes. Material and Methods: Cervical cancer patients operated in the gynecologic oncology division between 2007 and 2013 were retrospectively evaluated. One-hundred and sixty-eight patients with tumor size <= 4 cm were identified. Of these, 159 (86.8%) underwent radical hysterectomy plus pelvic-para- aortic lymphadenectomy and nine (13.2%) underwent fertility-sparing surgery [radical trachelectomy (n= 7); large conization (n=2)]. Factors affecting parametrial invasion, including lymphovascular space invasion (LVSI), deep stromal invasion (DSI), lymph node metastases, and tumor size, were evaluated. Statistical analyses were performed using SPSS 23.0 (IBM Corp., Armonk, NY, USA). Results: Median age was 49.5 years and median tumor size was 2.5 cm ( 0.45-4 cm). In both univariate and multivariate analyses, the risk of parametrial involvement was increased with LVSI with a hazard ratio (HR) of 3.45 [95% confidence interval (CI): 1.1-10.8] and DSI with a HR of 4.1 (95% CI: 1.18-14.8), while tumor size of <= 2 cm was only significant in univariate analyses. Furthermore, 26 early-stage patients were identified with low-risk factors and they had no parametrial involvement, lymph node metastases, recurrence, or death from disease over 77 months. Conclusion: Parametrial involvement in low-risk cervical cancer is very rare and less radical procedures may be safe in these patients.
dc.identifier.doi10.4274/jtgga.galenos.2020.2020.0153
dc.identifier.endpage41
dc.identifier.issn1309-0399
dc.identifier.issn1309-0380
dc.identifier.issue1
dc.identifier.pmid33506671
dc.identifier.scopus2-s2.0-85114522427
dc.identifier.scopusqualityQ3
dc.identifier.startpage37
dc.identifier.trdizinid408931
dc.identifier.urihttps://doi.org/10.4274/jtgga.galenos.2020.2020.0153
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/408931
dc.identifier.urihttps://hdl.handle.net/20.500.12418/27597
dc.identifier.volume22
dc.identifier.wosWOS:000622418900007
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherGalenos Yayincilik
dc.relation.ispartofJournal of the Turkish-German Gynecological Association
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectLow-risk cervical cancer
dc.subjectparametrial invasion
dc.subjectless radical surgery
dc.titleFactors affecting parametrial involvement in cervical cancer patients with tumor size ?4 cm and selection of low-risk patient group
dc.typeArticle

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