Synthesis and Caracterizations of New Thiosemicarbazone and Thiazole Derivatives From Polycyclic Chiral 1,5-Diketones
Küçük Resim Yok
Tarih
2023
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Wiley-V C H Verlag Gmbh
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Thiosemicarbazone derivatives have a wide spectrum of biological activity as well as various application areas such as forming complexes with metals, using as intermediates in the synthesis of heterocyclic bioactive compounds. Thiazole derivatives can be easily synthesized from thiosemicarbazones and are among the important compounds in demand in terms of biological activity. In this study, 14 new thiosemicarbazone derivatives were synthesized starting from polycyclic 1,5-diketone derivatives with five stereocenters, and 14 thiazole derivatives were synthesized from the reaction of the obtained thiosemicarbazones with 2-bromoacetophenone and their structure determinations were carried out using spectroscopic methods (1H-NMR, 13C-NMR, 2D-NMR, FT-IR and Q-TOF LC/MS). This synthesis route from polycyclic chiral 1,5-diketones may contribute to the design of new drug-like molecules, which are important in medicinal chemistry. Herein, 14 new thiosemicarbazone derivatives were synthesized starting from polycyclic 1,5-diketone derivatives with five stereocenters, and 14 thiazole derivatives were synthesized from the reaction of the obtained thiosemicarbazones with 2-bromoacetophenone and their structure determinations were carried out using spectroscopic methods.image
Açıklama
Anahtar Kelimeler
1,5-Diketone, Thiazole, Thiosemicarbazide, Thiosemicarbazone, Polycyclic compounds
Kaynak
Chemistryselect
WoS Q Değeri
Q3
Scopus Q Değeri
Q2
Cilt
8
Sayı
42
