Synthesis and Caracterizations of New Thiosemicarbazone and Thiazole Derivatives From Polycyclic Chiral 1,5-Diketones

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dc.contributor.authorGezegen, Hayreddin
dc.date.accessioned2024-10-26T18:05:27Z
dc.date.available2024-10-26T18:05:27Z
dc.date.issued2023
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractThiosemicarbazone derivatives have a wide spectrum of biological activity as well as various application areas such as forming complexes with metals, using as intermediates in the synthesis of heterocyclic bioactive compounds. Thiazole derivatives can be easily synthesized from thiosemicarbazones and are among the important compounds in demand in terms of biological activity. In this study, 14 new thiosemicarbazone derivatives were synthesized starting from polycyclic 1,5-diketone derivatives with five stereocenters, and 14 thiazole derivatives were synthesized from the reaction of the obtained thiosemicarbazones with 2-bromoacetophenone and their structure determinations were carried out using spectroscopic methods (1H-NMR, 13C-NMR, 2D-NMR, FT-IR and Q-TOF LC/MS). This synthesis route from polycyclic chiral 1,5-diketones may contribute to the design of new drug-like molecules, which are important in medicinal chemistry. Herein, 14 new thiosemicarbazone derivatives were synthesized starting from polycyclic 1,5-diketone derivatives with five stereocenters, and 14 thiazole derivatives were synthesized from the reaction of the obtained thiosemicarbazones with 2-bromoacetophenone and their structure determinations were carried out using spectroscopic methods.image
dc.description.sponsorshipScientific and Technological Research Council of Turkey [TUBITAK - 116Z480]
dc.description.sponsorshipThe authors are indebted to The Scientific and Technological Research Council of Turkey (Grant TUBITAK - 116Z480) for the financial support of this study.
dc.identifier.doi10.1002/slct.202303220
dc.identifier.issn2365-6549
dc.identifier.issue42
dc.identifier.scopus2-s2.0-85175995202
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1002/slct.202303220
dc.identifier.urihttps://hdl.handle.net/20.500.12418/29006
dc.identifier.volume8
dc.identifier.wosWOS:001098504500001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherWiley-V C H Verlag Gmbh
dc.relation.ispartofChemistryselect
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subject1,5-Diketone
dc.subjectThiazole
dc.subjectThiosemicarbazide
dc.subjectThiosemicarbazone
dc.subjectPolycyclic compounds
dc.titleSynthesis and Caracterizations of New Thiosemicarbazone and Thiazole Derivatives From Polycyclic Chiral 1,5-Diketones
dc.typeArticle

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