Association of Matrix Metalloproteinases and Their Tissue Inhibitor With Disease Activity and Development in Spondyloarthropathy and Inflammatory Bowel Disease

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dc.contributor.authorElmas, Dursun
dc.contributor.authorSahin, Ali
dc.contributor.authorKucuksahin, Orhan
dc.contributor.authorTurkcapar, Nuran
dc.contributor.authorToruner, Murat
dc.contributor.authorCetinkaya, Hulya
dc.contributor.authorKulahcioglu, Emre
dc.contributor.authorOkoh, Alexis K.
dc.contributor.authorTurgay, Murat
dc.date.accessioned2019-07-27T12:10:23Z
dc.date.accessioned2019-07-28T09:47:49Z
dc.date.available2019-07-27T12:10:23Z
dc.date.available2019-07-28T09:47:49Z
dc.date.issued2015
dc.department[Elmas, Dursun -- Kulahcioglu, Emre -- Okoh, Alexis K.] Ankara Univ, Dept Internal Med, Fac Med, TR-06100 Ankara, Turkey -- [Sahin, Ali] Cumhuriyet Univ, Dept Internal Med, Div Rheumatol, Fac Med, TR-58140 Sivas, Turkey -- [Kucuksahin, Orhan] Yildirim Beyazit Univ, Dept Internal Med, Div Rheumatol, Fac Med, Ankara, Turkey -- [Turkcapar, Nuran -- Turgay, Murat] Ankara Univ, Dept Internal Med, Div Rheumatol, Fac Med, TR-06100 Ankara, Turkey -- [Toruner, Murat -- Cetinkaya, Hulya] Ankara Univ, Dept Internal Med, Div Gastroenterol, Fac Med, TR-06100 Ankara, Turkeyen_US
dc.description.abstractObjectives: This study aims to investigate whether clinical measures of disease activity and function in ankylosing spondylitis (AS) and inflammatory bowel disease (IBD) are associated with matrix metalloproteinase-3 (MMP-3), matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of matrix metalloproteinase -1 (TIMP-1), and if MMPs can be more useful than C-reactive protein and erythrocyte sedimentation rate in predicting disease activity in AS. Patients and methods: MMP-3, MMP-9 and TIMP-1 levels were measured by ELISA in 20 patients with AS, 20 patients with IBD, 20 patients with IBD and AS (35 males, 25 females; mean age 38.1 years; range 19 to 62 years), and 20 healthy volunteers (10 males, 10 females; median age 38.5 years; range 24 to 63 years) as a control group. Bath Ankylosing Spondylitis Disease Activity Index, Truelove-Witts activity criteria for ulcerative colitis, and Crohn's Disease of Activity Index scoring systems were used. Results: Highest MMP-3 level was in IBD group (33.51 59.56 ng/mL, p<0.045). MMP-3 levels were significantly higher in patients with IBD and IBD+AS than in patients with AS (p<0.007 and p<0.035, respectively). Highest MMP-9 levels were in the control group (10.35 +/- 2.61 ng/mL, p<0.48). MMP-9 levels were higher in AS group patients than those in IBD and IBD+AS groups, but the difference was not statistically significant (p<0.494 and p<0.260, respectively). Highest TIMP-1 levels were in the IBD group (8.11 ng/mL, p<0.006).TIMP-1 levels of IBD group were significantly higher than both AS and IBD+AS groups (p<0.033 and p<0.008, respectively). A statistically significant correlation was detected between serum MMP-3 levels and disease activity and Bath Ankylosing Spondylitis Disease Activity Index score in patients with AS (r=0.841, p<0.05). Conclusion: We concluded that serum MMP-3 levels may be a better biomarker than C-reactive protein and erythrocyte sedimentation rate in showing disease activity in AS.en_US
dc.description.sponsorshipAnkara Tip War Vakfien_US
dc.description.sponsorshipThis study was funded by Ankara Tip War Vakfi.en_US
dc.identifier.doi10.5606/ArchRheumatol.2015.5064en_US
dc.identifier.endpage197en_US
dc.identifier.issn1309-0291
dc.identifier.issn2148-5046
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-84941052801en_US
dc.identifier.scopusqualityQ4
dc.identifier.startpage191en_US
dc.identifier.trdizinid177789en_US
dc.identifier.urihttps://dx.doi.org/10.5606/ArchRheumatol.2015.5064
dc.identifier.urihttps://hdl.handle.net/20.500.12418/7727
dc.identifier.volume30en_US
dc.identifier.wosWOS:000363083300002en_US
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherTURKISH LEAGUE AGAINST RHEUMATISMen_US
dc.relation.ispartofARCHIVES OF RHEUMATOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAnkylosing spondylitisen_US
dc.subjectinflammatory bowel diseaseen_US
dc.subjectmetalloproteinase-3en_US
dc.subjectmetalloproteinase-9en_US
dc.subjecttissue matrix metalloproteinase inhibitor-1en_US
dc.titleAssociation of Matrix Metalloproteinases and Their Tissue Inhibitor With Disease Activity and Development in Spondyloarthropathy and Inflammatory Bowel Diseaseen_US
dc.typeArticleen_US

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