Protective Effect of Melatonin and Mycophenolate Mofetil Against Nephrotoxicity Induced by Tacrolimus in Wistar Rats

Basit Öğe Kaydı
dc.contributor.authorKoc, Suleyman
dc.contributor.authorAktas, Ahmet
dc.contributor.authorSahin, Bilal
dc.contributor.authorOzkaraca, Mustafa
dc.date.accessioned2024-10-26T18:00:29Z
dc.date.available2024-10-26T18:00:29Z
dc.date.issued2022
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractAlthough Tacrolimus (TAC) is a potent and well-tolerated drug, it has some side effects. Melatonin and mycophenolate mofetil (MMF) have some protective properties against drug-induced damage. We aimed to evaluate TAC-induced nephrotoxicity and the protective effect of melatonin and MMF against this injury in rats. The animals were divided into five equal groups (n): Control group (untreated), group II TAC, group III as the TAC + melatonin, group IV as the TAC + MMF, and group V as the TAC + melatonin + MMF. TAC was applied orally, 2 mg/kg once daily. Melatonin and MMF were applied orally 10 mg/kg once and 40 mg/kg once daily, respectively. In the TAC group, kidney tissue malondialdehyde (MDA), total oxidative status (TOS), interleukin-1, and tumor necrosis factor-alpha levels were higher, and catalase and total antioxidant status (TAS) levels were lower. Severe histopathologic changes such as glomerular congestion, intertubular hemorrhage, hyaline formation, degenerative-necrotic tubules epithelium, and mononuclear cell infiltration were seen in the TAC group. There was a clear improvement in the groups in which melatonin and MMF were used together with TAC. It was shown that TAC causes nephrotoxicity through oxidative stress. Melatonin and MMF together or separately protect the kidney against oxidative stress damage caused by TAC.
dc.description.sponsorshipSivas Cumhuriyet University Project Office [CUBAP] [T-872]
dc.description.sponsorshipThis study was supported by grants from the Sivas Cumhuriyet University Project Office [CUBAP (T-872)].
dc.identifier.doi10.9775/kvfd.2021.26460
dc.identifier.endpage74
dc.identifier.issn1300-6045
dc.identifier.issue1
dc.identifier.scopus2-s2.0-85126473547
dc.identifier.scopusqualityQ3
dc.identifier.startpage67
dc.identifier.trdizinid517668
dc.identifier.urihttps://doi.org/10.9775/kvfd.2021.26460
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/517668
dc.identifier.urihttps://hdl.handle.net/20.500.12418/27708
dc.identifier.volume28
dc.identifier.wosWOS:000807197100001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherKafkas Univ, Veteriner Fakultesi Dergisi
dc.relation.ispartofKafkas Universitesi Veteriner Fakultesi Dergisi
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectTacrolimus
dc.subjectMelatonin
dc.subjectMycophenolate mofetil
dc.subjectNephrotoxicity
dc.subjectOxidative stress
dc.titleProtective Effect of Melatonin and Mycophenolate Mofetil Against Nephrotoxicity Induced by Tacrolimus in Wistar Rats
dc.typeArticle

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
TR-Dizin İndeksli Yayınlar Koleksiyonu