Relationship between Histone Deacetylase (HDAC) Overexpression and 18F-FDG PET/CT Parameters in Patients with Gastric Cancer, and Prognostic Importance of HDAC Overexpression

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dc.authoridYILMAZ, MUKADDES/0000-0002-7927-8480
dc.contributor.authorBabacan, Ozge Ulas
dc.contributor.authorHasbek, Zekiye
dc.contributor.authorYilmaz, Mukaddes
dc.contributor.authorOzer, Hatice
dc.contributor.authorAtaseven, Hilmi
dc.date.accessioned2024-10-26T18:02:01Z
dc.date.available2024-10-26T18:02:01Z
dc.date.issued2023
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractHiston Deacetylases (HDACs) exert a pro-oncogenic effect by keeping genes that cause differentiation, apoptosis, and cell cycle arrest in a transcriptionally quiescent state. Moreover to achieve our aim, we investigated the relationship between the patients' HDAC protein expression rates and their prognosis. In no patients, tumors were located in the cardia and corpus. While the median HDAC1 protein score was 3.5 in the early stage patients, it was 8 in the advanced stage (stage 1-2) patients, and 12 in the metastatic stage (stage 4) patients. There was a significant correlation between HDAC protein positivity and tumor localization (p= 0.030). Significant correlation was observed between histopathological stages and median HDAC1 protein scores. (p= 0.021). The HDAC1 protein score increased as the patients' stage progressed. Given the relationship between HDAC1 proteins and the survival of the patients, the 2-year survival rate was high in HDAC1 positive patients; however, it was not statistically significant. According to the results of our study, in HDAC1-positive gastric cancer patients, there was no significant relationship between SUVmax showing tumor metabolism in 18F-FDG PET/CT.
dc.description.sponsorshipCumhuri-yet University Scientific Research Projects Com-mission as a Medical Specialization Project [T-2021-924]
dc.description.sponsorshipFunding: This project was supported by Cumhuri-yet University Scientific Research Projects Com-mission as a Medical Specialization Project (Num-ber: T-2021-924) .
dc.identifier.doi10.4999/uhod.236787
dc.identifier.endpage143
dc.identifier.issn1306-133X
dc.identifier.issue3
dc.identifier.scopus2-s2.0-85175568406
dc.identifier.scopusqualityQ4
dc.identifier.startpage135
dc.identifier.trdizinid1265060
dc.identifier.urihttps://doi.org/10.4999/uhod.236787
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1265060
dc.identifier.urihttps://hdl.handle.net/20.500.12418/27902
dc.identifier.volume33
dc.identifier.wosWOS:001085924200003
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherAkad Doktorlar Yayinevi
dc.relation.ispartofUhod-Uluslararasi Hematoloji-Onkoloji Dergisi
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectHDAC
dc.subjectHDACI
dc.subject18F-FDG PET/CT
dc.subjectGastric cancer
dc.titleRelationship between Histone Deacetylase (HDAC) Overexpression and 18F-FDG PET/CT Parameters in Patients with Gastric Cancer, and Prognostic Importance of HDAC Overexpression
dc.typeArticle

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