Levels of oxidative stress and apoptosis-related biomarkers in endometriosis

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dc.authorid0000-0002-6834-020Xtr
dc.contributor.authorÜlger Özbek, Dilara
dc.contributor.authorSevtap Bakir
dc.contributor.authorsavaş karakuş
dc.date.accessioned2024-01-08T07:36:48Z
dc.date.available2024-01-08T07:36:48Z
dc.date.issued2023tr
dc.departmentRektörlüğe Bağlı İdari Birimlertr
dc.description.abstractAbstract Öz Purpose: In this study, the apoptosis marker M30, the oxidative stress markers malondialdehyde, (MDA) and asymmetric dimethyl arginine (ADMA) have been studied in the context of endometriosis. Materials and Methods: This prospective case-control study comprises 31 patients diagnosed with endometriosis and 31 controls. ADMA and M30 levels in blood serum were measured by the enzyme-linked immunosorbent assay (ELISA) method, and MDA levels were measured by the spectrophotometric method. In addition, some biochemical parameters and cancer antigen-125 (CA-125) levels were also measured. Results: M30 levels were statistically lower in endometriosis patients (271.5 IU/L) than in controls (371.3 IU/L). ADMA levels were higher in endometriosis patients (19.3 ng/L) compared to controls (12.7 ng/L). CA-125 levels were statistically higher in the endometriosis patients (65.1 U/mL) compared to the controls (19.0 U/mL). There was no significant difference between the two groups in MDA levels. The results regarding dyspareunia, pelvic pain, AST, and ALP were statistically significant. Conclusion: In our study, decreased M30 levels in the patient group were associated with reduced apoptosis in endometriosis. ADMA levels, elevated with the increase of oxidative stress, were higher in the patients. MDA levels, an indicator of increased oxidative stress, were also higher in the patient group. This study constitutes the first data regarding endometriosis patients' ADMA, M30, and MDA levels.tr
dc.identifier.doi10.17826/cumj.1247227en_US
dc.identifier.trdizinid1197739en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12418/14185
dc.identifier.wosWOS:001038321300020en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherCukurova Üniverstesitr
dc.relation.ispartofCukurova Medical Journalen_US
dc.relation.publicationcategoryUluslararası Hakemli Dergide Makale - Kurum Öğretim Elemanıtr
dc.rightsinfo:eu-repo/semantics/openAccesstr
dc.subjectEndometriozistr
dc.titleLevels of oxidative stress and apoptosis-related biomarkers in endometriosisen_US
dc.typeArticleen_US

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