VEGF, sVEGFR-1 and Endostatin Serum Levels and VEGF Polymorphisms in Recurrent Aphthous Stomatitis

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dc.contributor.authorYuce, Salim
dc.contributor.authorBagci, Binnur
dc.contributor.authorBagci, Gokhan
dc.contributor.authorDogan, Mansur
dc.contributor.authorKoc, Sema
dc.contributor.authorSezgin, Ilhan
dc.contributor.authorCandan, Ferhan
dc.contributor.authorUysal, Ismail Onder
dc.date.accessioned2019-07-27T12:10:23Z
dc.date.accessioned2019-07-28T09:44:56Z
dc.date.available2019-07-27T12:10:23Z
dc.date.available2019-07-28T09:44:56Z
dc.date.issued2016
dc.department[Yuce, Salim -- Dogan, Mansur -- Uysal, Ismail Onder] Cumhuriyet Univ, Fac Med, Dept Otorhinolaryngol, Sivas, Turkey -- [Bagci, Binnur] Cumhuriyet Univ, Fac Hlth Sci, Dept Nutr & Dietet, TR-58140 Sivas, Turkey -- [Bagci, Gokhan -- Sezgin, Ilhan] Cumhuriyet Univ, Fac Med, Dept Med Genet, Sivas, Turkey -- [Koc, Sema] Antalya Training & Res Hosp, Dept Otorhinolaryngol, Antalya, Turkey -- [Candan, Ferhan] Cumhuriyet Univ, Fac Med, Dept Internal Med, Sivas, Turkeyen_US
dc.description.abstractAim: Recurrent aphthous stomatitis (RAS) is one of the most frequent diseases of the oral mucosa, characterized by chronic, painful, recurrent, and necrotizing ulcerations. The precise etiology and pathogenesis of RAS have not been clarified. Therefore. we aimed to investigate serum levels of VEGF. sVEGFR-1, and endostatin as well as the frequencies of VEGF +936 C/T and -1154 C/A single nucleotide polymorphisms (SNPs) in Turkish patients with recurrent aphthous stomatitis. Material and Method: Forty-two patients with RAS (24 minor RAS and 18 major RAS) and 37 healthy subjects were included in the study. Serum levels of VEGF, sVEC FR-1, and endostatin were measured using the ELISA method. VEGF +936 C/T and-1154 C/A SNPs were determined by the PCR-RFLP method. Results: The mean serum level of VEGF was found higher in bearing CC genotype of +936 CFI SNP compared with CT genotype (639.5 +/- 309.1 vs 442.1 +/- 197.8: p = 0.032). VEGF-1154 GA genotype was found to be more frequent in patients with minor RAS and GG genotype was more frequent in patients with major RAS (p = 0.022). There was a significant difference between minor RAS and major RAS with regard to mean VEGF serum levels (677.1 +/- 316.7 vs 492.9 +/- 242.7; p = 0.032). Discussion: The T allele of +936 C/T SNP is associated with decreased serum VEGF level, and this decrease may have a contributory role in impaired neovascularization and re-epithelialization in the etiology and pathogenesis of RAS. Further studies are needed to determine the role of VEGF in RAS susceptibility and its clinical manifestations.en_US
dc.description.sponsorshipScientific Research Project Fund of Cumhuriyet University (CUBAP) [T-513]en_US
dc.description.sponsorshipThis work was supported by the Scientific Research Project Fund of Cumhuriyet University (CUBAP) under the project number T-513.en_US
dc.identifier.doi10.4328/JCAM.4523en_US
dc.identifier.endpage705en_US
dc.identifier.issn1309-0720
dc.identifier.issn1309-2014
dc.identifier.issue5en_US
dc.identifier.scopus2-s2.0-84983284437en_US
dc.identifier.scopusqualityN/A
dc.identifier.startpage701en_US
dc.identifier.trdizinid222498en_US
dc.identifier.urihttps://dx.doi.org/10.4328/JCAM.4523
dc.identifier.urihttps://hdl.handle.net/20.500.12418/7216
dc.identifier.volume7en_US
dc.identifier.wosWOS:000410618200028en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherDERMAN MEDICAL PUBLen_US
dc.relation.ispartofJOURNAL OF CLINICAL AND ANALYTICAL MEDICINEen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectRecurrent Aphthous Stomatitisen_US
dc.subjectVEGFen_US
dc.subjectVEGFR-1en_US
dc.subjectEndostatinen_US
dc.subjectPolymorphismen_US
dc.titleVEGF, sVEGFR-1 and Endostatin Serum Levels and VEGF Polymorphisms in Recurrent Aphthous Stomatitisen_US
dc.typeArticleen_US

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