Preparation of resveratrol containing poly (lactic-co-glycolic acid) nanoparticles and investigation of its cytotoxic effect in C6 glioma cells

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dc.contributor.authorDogan, Murat
dc.contributor.authorGurgah, Fatma Zisan
dc.date.accessioned2024-10-26T18:00:31Z
dc.date.available2024-10-26T18:00:31Z
dc.date.issued2022
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractCancer is a complex disease involving several important changes in cell morphology that ultimately lead to tumor formulation. The biological endpoint of cancer is the uncontrolled growth and proliferation of cells. Resveratrol (RES) is a polyphenolic compound from the stilbene family, which has an important place in the treatment of cancer, which is used as a pharmaceutical and nutraceutical. Studies have shown that RES has anti-tumor effects in addition to its antioxidant, antimicrobial and anti-inflammatory effects. RES protects the body against free radicals and inhibits metabolic events that induce the proliferation of cancer cells. RES is a chemically unstable compound that has problems crossing the blood-brain barrier. Therefore, it is concluded that carrier systems containing RES should be developed in order to increase the water dispersibility of resveratrol and to increase its bioavailability when taken orally. In this way, the RES will be successfully targeted to the tumor site and the undesirable properties of the unstable, heat-sensitive RES will be improved. For this purpose, drug delivery systems prepared using synthetic polymers such as Polylactic-co-glycolic acid (PLGA) have been developed. PLGA is a biodegradable and biocompatible polymer used in areas related to human health. In this study, cell culture study of C6 glioma cells obtained from ATCC was performed and for this purpose, biocompatible nanoparticles of RES with PLGA were prepared. With the preparation of these nanoparticles, the effects of RES on cell viability and the differences in the anticancer effect on cells were evaluated with the XTT cytotoxicity study.
dc.description.sponsorshipScientific and Technical Research Council of Turkey, TUBITAK, 2209A University Students Research Projects Support Program [1919B012002199]
dc.description.sponsorshipThe financial support was provided by Scientific and Technical Research Council of Turkey, TUBITAK, 2209A University Students Research Projects Support Program, (Application number:1919B012002199). In addition, this study was performed in the Pharmaceutical Technology Research Laboratory of the Faculty of Pharmacy of Sivas Cumhuriyet University and in the Cancer Research Center of the Faculty of Medicine of Sivas Cumhuriyet University.
dc.identifier.doi10.29228/jrp.189
dc.identifier.endpage919
dc.identifier.issn2630-6344
dc.identifier.issue4
dc.identifier.scopus2-s2.0-85133915428
dc.identifier.scopusqualityQ3
dc.identifier.startpage911
dc.identifier.trdizinid535927
dc.identifier.urihttps://doi.org/10.29228/jrp.189
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/535927
dc.identifier.urihttps://hdl.handle.net/20.500.12418/27734
dc.identifier.volume26
dc.identifier.wosWOS:000836312200019
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherMarmara Univ
dc.relation.ispartofJournal of Research in Pharmacy
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectResveratrol
dc.subjectPLGA
dc.subjectpolyvinyl alcohol
dc.subjectnanoparticles
dc.subjectcytotoxicity
dc.titlePreparation of resveratrol containing poly (lactic-co-glycolic acid) nanoparticles and investigation of its cytotoxic effect in C6 glioma cells
dc.typeArticle

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