Anakinra, an interleukin-1 receptor antagonist, increases the morphine analgesic effect and decreases morphine tolerance development by modulating oxidative stress and endoplasmic reticulum stress in rats

Basit Öğe Kaydı
dc.authoridTaskiran, Ahmet Sevki/0000-0002-5810-8415
dc.authoridAvci, Onur/0000-0003-0743-754X
dc.contributor.authorAvci, Onur
dc.contributor.authorTaskiran, Ahmet Sevki
dc.date.accessioned2024-10-26T18:00:31Z
dc.date.available2024-10-26T18:00:31Z
dc.date.issued2020
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractBackground/aim: Recent studies have shown that inflammation plays a role in morphine analgesia and tolerance development. Anakinra is a competitive inhibitor of IL-1 receptors and an antiinflammatory protein regulating IL-1 beta's biological activity by avoiding signal transduction. In this study, we aimed to examine the effects of anakinra on morphine analgesia and tolerance. Materials and methods: In this study, 36 Wistar Albino (230-250 g) male rats were used. Animals were divided into 6 groups: saline (S), 100 mg/kg anakinra (A), 5mg/kg morphine (M), M-FA, morphine tolerance (MT), and MT+A. The resulting analgesic effect was measured with hot plate and tail-flick analgesia tests. After the analgesia tests, the dorsal root ganglions (DRG) tissues were removed. Oxidative stress parameters [total antioxidant status (TAS), total oxidant status (FOS)] , endoplasmic reticulum (ER) stress, and apoptosis proteins [E74-like factor 2 (elF-2 alpha), activating transcription factor 4 (ATF-4), C/EBP homologous protein (CHOP), caspase-3, and bcl-2-associated X protein (bax)1 were measured in DRG tissues. Results: Anakinra showed an antinociceptive effect when given alone (1) < 0.001). In addition, anakinra increased the analgesic effect of morphine (P < 0.05 to P < 0.001), and also decreased the tolerance to morphine at a significant level (P < 0.05 to P < 0.001). Moreover, it decreased oxidative stress and ER-stress when given as a single-dose morphine and tolerance induction (P < 0.01 to P < 0.001). Furthermore, anakinra decreased apoptosis proteins after tolerance development (P < 0.001). Conclusion: Anakinra has antinociceptive properties, and it increases the analgesic effect of morphine and also prevents tolerance development. These effects probably occur by the modulation of oxidative stress and ER-stress pathways.
dc.identifier.doi10.3906/sag-2005-256
dc.identifier.endpage2058
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.issue8
dc.identifier.pmid32659878
dc.identifier.scopus2-s2.0-85096874576
dc.identifier.scopusqualityQ3
dc.identifier.startpage2048
dc.identifier.trdizinid535852
dc.identifier.urihttps://doi.org/10.3906/sag-2005-256
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/535852
dc.identifier.urihttps://hdl.handle.net/20.500.12418/27732
dc.identifier.volume50
dc.identifier.wosWOS:000600735500037
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTubitak Scientific & Technological Research Council Turkey
dc.relation.ispartofTurkish Journal of Medical Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAnakinra
dc.subjectmorphine analgesia
dc.subjectmorphine tolerance
dc.subjectoxidative stress
dc.subjectendoplasmic reticulum stress
dc.titleAnakinra, an interleukin-1 receptor antagonist, increases the morphine analgesic effect and decreases morphine tolerance development by modulating oxidative stress and endoplasmic reticulum stress in rats
dc.typeArticle

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksyonu
Scopus İndeksli Yayınlar Koleksiyonu
TR-Dizin İndeksli Yayınlar Koleksiyonu