Determination of 8-hydroxy-2?deoxyguanosine, malondialdehyde levels and antioxidant enzyme activities in Kangal dogs with venereal tumour

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dc.contributor.authorErcan, Nazli
dc.contributor.authorYuksel, Murat
dc.contributor.authorKockaya, Mustafa
dc.date.accessioned2024-10-26T18:00:06Z
dc.date.available2024-10-26T18:00:06Z
dc.date.issued2020
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractCanine transmissible venereal tumour (TVT) is a contagious cancer and sexually transmitted one dog to another by allogenic transfer of living cancer cells. The aim of this study is to examine the relationship between antioxidative metabolism and venereal tumour at Kangal Dogs and to show the size of oxidative damage it causes through 8-hydroxy-2'deoxyguanosine (8-OHdG). The materials of this study included the blood sera of 15 Kangal Dogs with TVT, and as a control group of 15 healthy Kangal Dogs. The sera levels of 8-OHdG were determined by competitive enzyme linked immunosorbent assay (ELISA) method. The level of malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GPx) and catalase (CAT) which are antioxidative enzymes were investigated by spectrophotometric methods as described. Serum 8-OHdG and MDA levels of dogs with TVT were found to be significantly increased compared to the control group (P<0.001). The levels of GPx were statistically different (P<0.05). In the light of the findings, which are obtained in this study, the transmissible venereal tumour, which is an infectious and treatable type of cancer, can lead to new studies that may be caused by oxidant-antioxidant metabolism.
dc.description.sponsorshipSivas Cumhuriyet University Scientific Research Project Coordination Unit [V-042]
dc.description.sponsorshipThis study was supported by the Sivas Cumhuriyet University Scientific Research Project Coordination Unit under the project number 'V-042'.
dc.identifier.doi10.33988/auvfd.492765
dc.identifier.endpage125
dc.identifier.issn1300-0861
dc.identifier.issn1308-2817
dc.identifier.issue2
dc.identifier.scopus2-s2.0-85081214635
dc.identifier.scopusqualityQ3
dc.identifier.startpage121
dc.identifier.trdizinid360796
dc.identifier.urihttps://doi.org/10.33988/auvfd.492765
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/360796
dc.identifier.urihttps://hdl.handle.net/20.500.12418/27531
dc.identifier.volume67
dc.identifier.wosWOS:000518473700002
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherAnkara Univ Press
dc.relation.ispartofAnkara Universitesi Veteriner Fakultesi Dergisi
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAntioxidant enzyme
dc.subjectKangal dog
dc.subjecttransmissible venereal tumour
dc.subject8-OHdG
dc.titleDetermination of 8-hydroxy-2?deoxyguanosine, malondialdehyde levels and antioxidant enzyme activities in Kangal dogs with venereal tumour
dc.typeArticle

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