Comparison of caspase-8, granzyme B and cytochrome C apoptosis biomarker levels in orthopedic trauma patients

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dc.contributor.authorPazarci, Ozhan
dc.contributor.authorAydin, Huseyin
dc.contributor.authorKilinc, Seyran
dc.date.accessioned2024-10-26T18:00:06Z
dc.date.available2024-10-26T18:00:06Z
dc.date.issued2020
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractBACKGROUND: The primary objective of this study was to investigate whether or not apoptosis is induced following bone fracture, and if so, to investigate whether the extrinsic or intrinsic pathway of cell death is stimulated. METHODS: A total of 30 patients who presented at our clinic and were diagnosed with bone fracture following trauma were included in the study group. A control group was formed of 37 age and gender-matched volunteers. On the day after the fracture, blood samples taken from the patients were examined for cytochrome C, granzyme B and caspase-8 with the ELISA method. RESULTS: A total of 67 individuals were evaluated (fracture group: 30, control group: 37) in this study. Caspase-8 was found to be statistically significantly high in the patient group (0.37 +/- 0.06 ng/mL, p=0.002). No significant difference was determined between the groups in respect to cytochrome C values (p=0. 173). The granzyme B values were determined to be significantly high in the patient group (52.56 +/- 8.51 pg/mL, p=0.007). CONCLUSION: These results obtained from patients with a long bone fracture demonstrated that serum caspase-8 and granzyme B levels were higher in patients than in the control group, thereby showing activation of the extrinsic pathway. However, no significant difference was determined between the groups concerning serum cytochrome C levels. This study may guide future studies designed for better understanding of the molecular pathways that govern the events during a fracture, which will be important for the future advancement of fracture treatment.
dc.identifier.doi10.14744/tjtes.2019.02680
dc.identifier.endpage279
dc.identifier.issn1306-696X
dc.identifier.issue2
dc.identifier.pmid32185754
dc.identifier.scopus2-s2.0-85081257634
dc.identifier.scopusqualityQ2
dc.identifier.startpage274
dc.identifier.trdizinid360196
dc.identifier.urihttps://doi.org/10.14744/tjtes.2019.02680
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/360196
dc.identifier.urihttps://hdl.handle.net/20.500.12418/27526
dc.identifier.volume26
dc.identifier.wosWOS:000528165700018
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTurkish Assoc Trauma Emergency Surgery
dc.relation.ispartofUlusal Travma ve Acil Cerrahi Dergisi-Turkish Journal of Trauma & Emergency Surgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectApoptosis
dc.subjectcaspase-8
dc.subjectcytochrome C
dc.subjectfracture
dc.subjectgranzyme B
dc.titleComparison of caspase-8, granzyme B and cytochrome C apoptosis biomarker levels in orthopedic trauma patients
dc.typeArticle

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